Redox regulation and NO/cGMP plus K+ channel activation contributes to cardiorenal protection induced by Cuphea carthagenensis (Jacq.) J.F. Macbr. in ovariectomized hypertensive rats

Schaedler, Maysa Isernhagen; Palozi, Rhanany Alan Calloi; Tirloni, Cleide Adriane Signor; Silva, Aniely Oliveira; Araújo, Valdinei de Oliveira; Lourenço, Emerson Luiz Botelho; Souza, Lauro Mera de; Lívero, Francislaine Aparecida dos Reis; Gasparotto, Arquimedes

doi:10.1016/j.phymed.2018.05.011

Cited by 12 publications

(15 citation statements)

References 44 publications

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“…The left renal artery was dissected for the placement of a silver clip (7 mm x 1 mm, 0.35 mm opening). The clip was closed at its distal end to induce unilateral renal ischemia (Schaedler et al 2018). The abdominal cavity was then closed with continuous sutures (#10 cotton thread).…”

Section: Experimental Designmentioning

confidence: 99%

“…After the blood pressure measurements, the rats underwent laparotomy. Mesenteric vascular beds (MVBs) were isolated and prepared for perfusion according to previously described methods (Schaedler et al 2018). The MVBs were placed in a water-jacketed organ bath and perfused with physiologic saline solution (PSS; composition: 119 mM NaCl, 4.7 mM KCl, 2.4 mM CaCl 2 , 1.2 mM MgSO 4 , 25.0 mM NaHCO 3 , 1.2 mM KH 2 PO 4 , 11.1 mM dextrose, and 0.03 mM TATIANE C. MENDES et al Bras Cienc (2021) 93(3) e20200899 5 | 16 ethylenediaminetetraacetic acid) at 37ºC at a rate of 4 ml/min with 95% O 2 /5% CO 2 .…”

Section: Vascular Reactivitymentioning

confidence: 99%

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Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Mendes¹,

Silva²,

Silva

et al. 2021

An. Acad. Bras. Ciênc.

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Cardiovascular diseases are associated with high morbidity and mortality worldwide and have several risk factors, including dyslipidemia, smoking, and hypertension. Studies have evaluated isolated risk factors in experimental models of cardiovascular disease, but few preclinical studies have assessed associations between multiple risk factors. In the present study, hypertensive Wistar rats (Goldblatt 2K1C model) received a 0.5% cholesterol diet and were exposed to tobacco smoke for 8 weeks.During the last 4 weeks, the animals were treated with vehicle, an ethanol-soluble fraction of B. trimera (30, 100, and 300 mg/kg), or simvastatin + enalapril. A group of normotensive, non-dyslipidemic, and non-smoking rats was treated with vehicle. The levels of aspartate aminotransferase, alanine aminotransferase, urea, creatinine, and hepatic and fecal lipids, blood pressure, and mesenteric arterial bed reactivity were evaluated. Cardiac, hepatic, and renal histopathology and tecidual redox state were also investigated. Untreated animals exhibited signifi cant changes in blood pressure, lipid profi le, and biomarkers of heart, liver, and kidney damage. Treatment with B. trimera reversed these changes, with effects that were similar to simvastatin + enalapril. These fi ndings suggest that B. trimera may be promising for the treatment of cardiovascular and hepatic disorders, especially disorders that are associated with multiple risk factors.

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Section: Experimental Designmentioning

confidence: 99%

Section: Vascular Reactivitymentioning

confidence: 99%

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Mendes¹,

Silva²,

Silva

et al. 2021

An. Acad. Bras. Ciênc.

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“…UHPLC-MS/UPLC-MS C. carthagenensis samples also were investigated for mass spectrometry, using UPLC -Acquity™ Waters, PDA detector, coupled to high-resolution mass spectrometry (HR-MS). On C18 column HSS T3 (100 x 2.1 mm, 1.7 mm, Waters) using ultrapure water (A) and acetonitrile (B), both containing 0.1% formic acid, with a gradient increasing solvent B: 0-30% in 7 min, 30-80% in 12 min, returning to initial condition in 15 min [23,34], and a flow rate of 400 µL/min [34]. Equally, Prando et al [35] explored C. carthagenensis samples by UPLC -Acquity™ Waters, modifying the mobile phase (0.1% aqueous formic acid (A) and methanol (B)) and the gradient at a flow rate of 0.4 mL/min.…”

Section: Uhplc/uplcmentioning

confidence: 99%

“…Equally, Prando et al [35] explored C. carthagenensis samples by UPLC -Acquity™ Waters, modifying the mobile phase (0.1% aqueous formic acid (A) and methanol (B)) and the gradient at a flow rate of 0.4 mL/min. Phytochemical investigation for C. carthagenensis leaves was performed mass spectrometry in LTQ-Orbitrap XL (Thermo Scientific), with electrospray ionization in the negative and positive modes [23,34,35]. Similarly, in the three studies, the samples from C. carthagenensis showed the same compounds, mainly flavonol glycosides [23,34,35].…”

Section: Uhplc/uplcmentioning

confidence: 99%

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Analytical methods of phytochemicals from the Cuphea genus - A review

2021

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Cuphea genus (Lythraceae) comprises about 260 species. The dispersion of the genus occurs in two mains geographic centers: North and South America, with Brazil being the most Cuphea species-rich country, with approximately 104 identified species. Still poorly studied, the number of papers about genus has been growing considerably. However, a review of its analytical methods has not been previously performed. Therefore, this review aims to provide studies about different chromatographic methods used for the separation, elucidation, and identification of metabolites present in species of the Cuphea genus. Research in scientific databases like Scopus, PubMed, and Science Direct were managed, and all references were analyzed. This review covers the relevant literature until May 2021, totalizing 22 studies described on 12 species of Cuphea. Most methods were employed for chemical analysis, and just one of them was validated for quantification purposes. Thus, this review provides a brief overview of the different chromatographic methods used in the separation, elucidation, and identification of compounds on different species of the Cuphea genus.

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Inhibition of biofilm and quorum sensing-regulated virulence factors in Pseudomonas aeruginosa by Cuphea carthagenensis (Jacq.) J. F. Macbr. Leaf extract: An in vitro study

Rather

Gupta

Mandal

2021

Journal of Ethnopharmacology

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Redox regulation and NO/cGMP plus K+ channel activation contributes to cardiorenal protection induced by Cuphea carthagenensis (Jacq.) J.F. Macbr. in ovariectomized hypertensive rats

Cited by 12 publications

References 44 publications

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Analytical methods of phytochemicals from the Cuphea genus - A review

Inhibition of biofilm and quorum sensing-regulated virulence factors in Pseudomonas aeruginosa by Cuphea carthagenensis (Jacq.) J. F. Macbr. Leaf extract: An in vitro study

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