Redox reactivity of cerium oxide nanoparticles against dopamine

Hayat, Akhtar; Andreescu, Daniel; Bülbül, Gonca; Andreescu, Silvana

doi:10.1016/j.jcis.2013.12.007

Cited by 68 publications

(69 citation statements)

References 24 publications

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“…Oxidation and formation of charge transfer complexes between ceria and dopamine was demonstrated previously with FTIR spectroscopy, XPS and UV-VIS spectroscopy [36]. The extent of change in optical properties of nanoceria particles upon exposure to phenolic compounds is associated to the ratio of Ce +4 and Ce +3 in the nanoparticle system and formation of charge transfer complexes.…”

Section: Oxidase Like Activity Of Nanoceria: Proof Of Concept For Nansupporting

confidence: 57%

Evaluation of the oxidase like activity of nanoceria and its application in colorimetric assays

Hayat

Cunningham

Bülbül

et al. 2015

Analytica Chimica Acta

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Nanomaterial-based enzyme mimics have attracted considerable interest in chemical analysis as alternative catalysts to natural enzymes. However, the conditions in which such particles can replace biological catalysts and their selectivity and reactivity profiles are not well defined. This work explored the oxidase like properties of nanoceria particles in the development of colorimetric assays for the detection of dopamine and catechol. Selectivity of the system with respect to several phenolic compounds, the effect of interferences and real sample analysis are discussed. The conditions of use such as buffer composition, selectivity, pH, reaction time and particle type are defined. Detection limits of 1.5 and 0.2μM were obtained with nanoceria for dopamine and catechol. The same assay could be used as a general sensing platform for the detection of other phenolics. However, the sensitivity of the method varies significantly with the particle type, buffer composition, pH and with the structure of the phenolic compound. The results demonstrate that nanoceria particles can be used for the development of cost effective and sensitive methods for the detection of these compounds. However, the selection of the particle system and experimental conditions is critical for achieving high sensitivity. Recommendations are provided on the selection of the particle system and reaction conditions to maximize the oxidase like activity of nanoceria.

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Section: Oxidase Like Activity Of Nanoceria: Proof Of Concept For Nansupporting

confidence: 57%

Evaluation of the oxidase like activity of nanoceria and its application in colorimetric assays

Hayat

Cunningham

Bülbül

et al. 2015

Analytica Chimica Acta

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“…We have used commercially available nanoceria particle dispersion in acetic acid with a particle size of 17.5(±1.1) nm and a zeta potential value of +34.5(±3.4) mV that was characterized by high reactivity in our previous work. [15] Figure 1. Structure of primary catechol-bearing molecules selected as model compounds to study nanoceria reactivity.…”

Section: Resultsmentioning

confidence: 99%

“…Studies in model biological systems have shown potential neurotoxic effects and alteration in the level of serotonin in living systems exposed to nanoceria [14] as well as adsorption of dopamine in human serum. [15] While research is progressing, not much is known about the fundamental parameters driving the interaction of these particles with catecholic molecules, which limits the understanding of their reactivity and potential effects. Several studies reported surface adsorption and complexation of phenol and catechol on metal oxide nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Reactivity of nanoceria particles exposed to biologically relevant catechol-containing molecules

et al. 2016

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The interaction of nanoceria particles with catechol-like molecules of physiological importance, including dopamine, norepinephrine, epinephrine, serotonin, 3,4 dihydroxyphenylaceticacid (DOPAC) and L-3-(3, 4-dihydroxyphenylalanine) (L-DOPA) was studied to obtain predictive information of their behavior in biological systems. A suite of complementary techniques including UV/Vis spectroscopy, electrochemistry, dynamic light scattering (DLS), thermogravimetric analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR) demonstrated alteration in the spectral, redox and surface properties of nanoceria exposed to these molecules in an aqueous environment. Binding of catechol to the surface of nanoceria diminished the oxidase-like activity of these particles against an organic dye, TMB (3,3,5,5tetramethylbenzedine), but enhanced their ability to react with and inactivate reactive oxygen species. Therefore, the reactivity of these particles can be modulated by addition of catechol-like molecules.These findings can help develop predictive models of the behavior and potential effects of nanoceria particles in complex environments.

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“…Subsequently, they found that nanoceria could oxidize the nonfluorescent substrate (ampliflu red) both in natural and acidic pH with different products. [32] Hayat and co-workers [52] demonstrated the oxidation and charge transfer complexes formation between 20 -25 nm nanoceria and dopamine with Fourier Transform Infra-red (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and Ultraviolet-Visible (UV-Vis) spectroscopy. They also tested the oxidase mimetics of different types of nanoceria, and found the oxidase mimetic activity was a common feature for different nanoceria, but varied with the particle size and Zeta potential.…”

Section: Mimetics Of Oxidasesmentioning

confidence: 99%

Ceria Nanoparticles as Enzyme Mimetics

Wang

Zhang

et al. 2017

Chin. J. Chem.

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In the past decades, enzyme mimetics based on ceria nanoparticles (nanoceria) have been developed as potential substitutes for nature enzymes. The mixed valence states of cerium and the patterns of oxygen vacancies on crystal planes result in different enzyme mimetic activities. In this review we survey the bio-applications of nanoceria-based enzyme mimetics as well as the underlying mechanisms. Factors influencing the enzyme mimetic activities and future perspective of nanoceria-based enzyme mimetics are also addressed.

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Redox reactivity of cerium oxide nanoparticles against dopamine

Cited by 68 publications

References 24 publications

Evaluation of the oxidase like activity of nanoceria and its application in colorimetric assays

Evaluation of the oxidase like activity of nanoceria and its application in colorimetric assays

Reactivity of nanoceria particles exposed to biologically relevant catechol-containing molecules

Ceria Nanoparticles as Enzyme Mimetics

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