Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery

Qu, Ying; Chu, Bingyang; Wei, Xiawei; Lei, Minyi; Hu, Danrong; Zha, Ruoyu; Zhong, Lin; Wang, Mengyao; Wang, Fangfang; Zhang, Qian

doi:10.1016/j.jconrel.2019.01.016

Cited by 140 publications

(89 citation statements)

References 59 publications

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“…Zusätzlich zu pH‐Gradienten werden auch Redoxgradienten, die durch das Glutathion‐Niveau (GSH) zwischen extrazellulären Flüssigkeiten (2–10 μ m) und dem Zytosol (ca. 10 m m ) induziert werden, oft als Auslöser für die schnelle intrazelluläre Wirkstoffabgabe aus disulfidverknüpften Nanogelen verwendet [43] . Die Disulfidbindungen können entweder durch disulfidhaltige Vernetzer (z.B.…”

Section: Herstellungsmethoden Für Nanogeleunclassified

Rationales Design von Nanogelen zur Überwindung biologischer Barrieren auf verschiedenen Verabreichungswegen

Zhao

Zhang

et al. 2021

Angewandte Chemie

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Nanogele haben sich aufgrund ihrer erstrebenswerten physikochemischen Eigenschaften und vielseitigen Anwendbarkeit auf diverse therapeutische Moleküle und bildgebende Sonden als herausragende Kandidaten für Nanocarrier zur Wirkstoffabgabe herausgestellt. Eine der zentralen Herausforderungen, welche die klinische Anwendung von Nanogelen verhindert, ist die geringe Effizienz der Wirkstoffübermittlung an das Ziel infolge des Widerstands komplexer biologischer Barrieren im Laufe des Transports in vivo. Ziele dieses Aufsatzes sind eine Untersuchung und Zusammenfassung der jüngsten Fortschritte beim rationalen Design und in der Strukturmodulation von Nanogelen zur Überwindung der Barrieren und Herausforderungen auf dem Weg zum Ziel, eingeteilt nach den unterschiedlichsten Dosiermodi. Insbesondere wurden funktionale Motive oder Domänen in Nanogele inkorporiert, wodurch eine spontane Regulierung ihrer Struktur und physiochemischen Eigenschaften ermöglicht wurde. Diese erlaubt die Überschreitung einer oder mehrerer der vielgestaltigen Barrieren. Zusätzlich werden künftige Perspektiven für die präzise und effiziente Formulierung therapeutischer Nanogele aufgezeigt.

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Section: Herstellungsmethoden Für Nanogeleunclassified

Rationales Design von Nanogelen zur Überwindung biologischer Barrieren auf verschiedenen Verabreichungswegen

Zhao

Zhang

et al. 2021

Angewandte Chemie

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“…The multiple endogenous sensitive smart materials were common in many works, such as dual responsive materials to pH and GSH, 273–277 pH and hypoxia, 131 pH and enzyme, 173 ROS and GSH, 60,278,279 GSH and hypoxia, 280,281 as well as GSH and enzyme 183 . There were also examples of triple responsive materials which were sensitive to pH, GSH, and enzyme 161,282 …”

Section: Multiple‐triggered Smart Materialsmentioning

confidence: 99%

Smart materials for drug delivery and cancer therapy

Yang

Zeng

Huang

et al. 2020

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119

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Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive smart materials possess many properties, such as responding ability to specific triggers, controlled drug release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, and therapeutic efficacy. Smart materials have attracted considerable attention because they provide likelihood strategy for individualized and comprehensive therapy. In this review, significant research achievements of smart materials responsive to different triggers including their synthesis and formulation mechanism, responsive mechanism, applications, multiple functions are summarized and discussed separately. We primarily focus on the studies in the past few years (2017‐2020). The current situation and remaining challenges of stimuli‐sensitive materials‐based nanocarriers for clinical translation are discussed rationally at the end. It is hope that this timely and overall review would provide some helpful information for researchers in this field.

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“…Dual stimuli‐responsive nanogels generally involve a combination of redox‐responsive cross‐linkers and pH‐responsive polymeric matrix as important nanogel constituents. Some of the important examples of pH‐responsive polymers are polyacrylamide (PAAm), poly(acrylic acid) (PAA), PMAA, poly(2‐diethylaminoethyl methacrylate) (PDEAEMA), polyethyleneimine, poly( l ‐lysine), poly(2‐vinyl pyridine) (P2VP), poly( N ‐vinylamine) (PVAm), poly(4‐vinyl pyridine) (P4VP), and chitosan . The pH‐ and redox‐responsive nanogels hold excellent potential and play a diverse role for targeted intracellular release of drugs due to their multidimensional role in response to variation in GSH concentration and pH inside the cellular compartment.…”

Section: Dual and Triple Stimuli‐responsive Nanogelsmentioning

confidence: 99%

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Kumar

Liu

Behl

2019

Macromolecular Bioscience

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Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel–based drug delivery carriers utilizing redox‐responsive cross‐linkers bearing a variety of functional groups via various synthetic strategies. Redox‐responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox‐responsive nanogels. The present review provides an insight into the design and fabrication of redox‐responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox‐responsive cross‐linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli‐responsive nanogels is also discussed.

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Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery

Cited by 140 publications

References 59 publications

Rationales Design von Nanogelen zur Überwindung biologischer Barrieren auf verschiedenen Verabreichungswegen

Rationales Design von Nanogelen zur Überwindung biologischer Barrieren auf verschiedenen Verabreichungswegen

Smart materials for drug delivery and cancer therapy

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

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