Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy

Scuto, Maria; Modafferi, Sergio; Rampulla, Francesco; Zimbone, Vincenzo; Tomasello, Mario; Spanò, S.F.; Ontario, Maria Laura; Palmeri, Agostino; Salinaro, Angela Trovato; Siracusa, Rosalba; Paola, Rosanna Di; Cuzzocrea, Salvatore; Calabrese, Edward J.; Wenzel, U.; Calabrese, Vittorio

doi:10.1016/j.mad.2022.111686

Cited by 16 publications

(11 citation statements)

References 309 publications

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“…Moreover, the hormesis-mediated cellular defense mechanisms exhibit more prolonged protective effects compared to conventional antioxidants. This is particularly relevant for oxidative stress-sensitive neuronal cells, where their crucial role in neuroprotection may offer new research perspectives and therapeutic strategies for addressing age-related pathologies such as neuroinflammation, cognitive disorders, and age-related neurodegenerative diseases [110][111][112][113][114][115][116] . In addition, mitohormesis can also delay aging by promoting stem cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…According to Supplementary Dataset 4 and Fig. 5a, the journal with the highest number of publications is Dose-Response (170), followed by Human and Experimental Toxicology (111), Science of the Total Environment (95), and several other journals with fewer than 80 publications. Among the top 10 journals in hormesis research, six are categorized as Q1 in the Journal Citation Reports (JCR2022), indicating their high impact and influence in the field.…”

Section: Distribution By Journalsmentioning

confidence: 99%

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Current advances and future trends of hormesis in disease

Wan,

Liu,

Mai

et al. 2024

npj Aging

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Hormesis, an adaptive response, occurs when exposure to low doses of a stressor potentially induces a stimulatory effect, while higher doses may inhibit it. This phenomenon is widely observed across various organisms and stressors, significantly advancing our understanding and inspiring further exploration of the beneficial effects of toxins at doses both below and beyond traditional thresholds. This has profound implications for promoting biological regulation at the cellular level and enhancing adaptability throughout the biosphere. Therefore, conducting bibliometric analysis in this field is crucial for accurately analyzing and summarizing its current research status. The results of the bibliometric analysis reveal a steady increase in the number of publications in this field over the years. The United States emerges as the leading country in both publication and citation numbers, with the journal Dose–Response publishing the highest number of papers in this area. Calabrese E.J. is a prominent person with significant contributions and influence among authors. Through keyword co-occurrence and trend analysis, current hotspots in this field are identified, primarily focusing on the relationship between hormesis, oxidative stress, and aging. Analysis of highly cited references predicts that future research trends may center around the relationship between hormesis and stress at different doses, as well as exploring the mechanisms and applications of hormesis. In conclusion, this review aims to visually represent hormesis-related research through bibliometric methods, uncovering emerging patterns and areas of focus within the field. It provides a summary of the current research status and forecasts trends in hormesis-related research.

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Section: Discussionmentioning

confidence: 99%

Section: Distribution By Journalsmentioning

confidence: 99%

Current advances and future trends of hormesis in disease

Wan,

Liu,

Mai

et al. 2024

npj Aging

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“…Polyphenols that largely exist in plants serve as reactive oxygen species scavengers with prominent antioxidant activity, which exert the inhibitory effects on inflammation by manipulating the inflammation-related signaling pathways and suppressing the release of inflammatory mediators ( 48 , 49 ). Not only contributing to treating non-neoplastic diseases, such as natural inducers from saffron targeting Nrf2/vitagene pathway to suppress oxidative stress and neuroinflammation and consequently inhibiting cognitive dysfunction ( 50 ), polyphenols could also play their roles in preventing and treating tumors by regulating cell apoptosis, autophagy, cell-cycle progression, inflammation, invasion, and metastasis through the activation of tumor suppressor genes and the inhibition of oncogenes ( 51 , 52 ). Professor Scuto M’s team demonstrated that, polyphenols with low concentrations could suppress oxidative stress and inflammation, and induced the apoptotic of brain cancer cells by activating Nrf2/vitagene pathway ( 53 ), in addition, the supplementation of dietary polyphenols and vitamin D can also manipulate oxidative stress, inflammation and autophagy dysfunction in tumor cells through Nrf2/vitagene pathway, the low concentrated polyphenols and vitamin D could serve as cytotoxic agents of pro-oxidants, in the form of molecular activation through reactive oxygen species production and several survival pathways (e. g., glutathione) to induce apoptosis and cell-cycle arrest in tumor cells, for the chemoprevention and treatment of tumors in the presence of metal ions.…”

Section: Discussionmentioning

confidence: 99%

Progress of research on tumor organoids: A bibliometric analysis of relevant publications from 2011 to 2021

et al. 2023

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BackgroundResearch on tumor organoids has developed rapidly over the past 20 years, but a systematic analysis of current research trends is lacking. Researchers in the field need relevant references and knowledge of current research hot spots. Bibliometric analysis and visualization is a systematic method of acquiring an in-depth understanding of the status of research on tumor organoids.MethodsCiteSpace, VOSviewer and the Bibliometric Online Analysis Platform from the Web of Science Core Collection were used to analyze and predict publishing trends and research hot spots worldwide in the field of tumor organoids.ResultsA total of 3,666 publications on tumor organoids were retrieved, and 2,939 eligible articles were included in the final analysis. The number of publications has grown significantly, with the United States of America as the leading country for research on tumor organoids. Among journals, Cancers published the largest number of articles. Harvard Medical School published the highest number of articles among all institutions. The Chinese Academy of Sciences was ranked highest among all contributing institutions on the importance of their publications. A trend in multi-disciplinary collaboration was observed in studies on tumor organoids. Keywords indicated that the current research largely concentrated on optimizing the construction of organoid models to use for medication development and screening in the clinical setting, and to provide patients with individualized treatment for gastric cancer and colorectal cancer, which are newly emerging research hotspots. Gastric and colorectal cancers were the top two tumors that have received increasing attention and have become the focal points of recent studies.ConclusionThis study analyzed 2,939 publications covering the topic of tumor organoids. Although optimizing the construction of organoid models has always been a hot topic in this field, the application of tumor organoids to the development of medications and screenings will foster individualized treatment for patients, which is another emerging hot spot in this field of research.

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“…All these enzymes and molecules control the level of a variety of reactive oxygen species (ROS) limiting the potential toxicity and fighting the damage cell membrane. Glutathione peroxidase on the other hand is an intracellular enzyme that enzymatically reduces the hydrogen peroxide to water so it can limit its harmful effects (Scuto et al, 2019;Scuto et al, 2022). The dose-depending effect of the C sativus L. (saffron) as a therapeutical agent is reported in different studies.…”

Section: Underlying Cellular and Molecular Mechanisms Of Saffron And ...mentioning

confidence: 99%

Therapeutic potential of saffron in brain disorders: From bench to bedside

Bej,

Volpe,

Cesare

et al. 2024

Phytotherapy Research

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Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various bioactive constituents, such as crocin, crocetin, safranal, picrocrocin, and kaempferol, that have shown potential benefits for human health. Among them, crocin is the most abundant and characteristic constituent of saffron, responsible for its bright red color and antioxidant properties. One of the most promising applications of saffron and its constituents is in the prevention and treatment of neurological disorders, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, and other brain disorders. Saffron and its constituents have been reported to exert neuroprotective effects through various mechanisms, such as modulating neurotransmitters, enhancing neurogenesis, reducing neuroinflammation, regulating oxidative stress, activating the Nrf2 signaling pathway, and modulating epigenetic factors. Several clinical and preclinical studies have demonstrated the efficacy and safety of saffron and its constituents in improving cognitive function, mood, and other neurological outcomes. In this review, we summarize the current evidence on the therapeutic potential of saffron and its constituents in neurological disorders, from bench to bedside. We also discuss the challenges and future directions for the development of saffron‐based therapies for brain health.

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Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy

Cited by 16 publications

References 309 publications

Current advances and future trends of hormesis in disease

Current advances and future trends of hormesis in disease

Progress of research on tumor organoids: A bibliometric analysis of relevant publications from 2011 to 2021

Therapeutic potential of saffron in brain disorders: From bench to bedside

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