Redox‐mediated structural and functional switching of C‐repeat binding factors enhances plant cold tolerance

Wi, Seong Dong; Lee, Eun Seon; Park, Joung Hun; Chae, Ho Byoung; Paeng, Seol Ki; Bae, Su Bin; Phan, Thi Kieu Anh; Kim, Woe‐Yeon; Yun, Dae‐Jin; Lee, Sang Yeol

doi:10.1111/nph.17745

Cited by 12 publications

(12 citation statements)

References 41 publications

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“…In addition to PTMS, the ICE-CBF is also regulated by the hormonal responses of jasmonates (JA), ethylene, brassinosteroids (BR) [32], gibberellin (GA) [33], auxin, and salicylic acid (SA). Numerous auxin-related genes have been thoroughly discussed which include auxin biosynthetic genes (CYP79B3 and CYP83B1) and auxin carrier genes (LAX1/2), and their down-regulatory effect in CBF expression [34]. Interestingly, exogenous treatment of several hormones on plants during cold stress has also been demonstrated to relieve the cold stress in plants.…”

Section: Introductionmentioning

confidence: 99%

ICE-CBF-COR Signaling Cascade and Its Regulation in Plants Responding to Cold Stress

Hwarari

Guan

Ahmad

et al. 2022

IJMS

147

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Cold stress limits plant geographical distribution and influences plant growth, development, and yields. Plants as sessile organisms have evolved complex biochemical and physiological mechanisms to adapt to cold stress. These mechanisms are regulated by a series of transcription factors and proteins for efficient cold stress acclimation. It has been established that the ICE-CBF-COR signaling pathway in plants regulates how plants acclimatize to cold stress. Cold stress is perceived by receptor proteins, triggering signal transduction, and Inducer of CBF Expression (ICE) genes are activated and regulated, consequently upregulating the transcription and expression of the C-repeat Binding Factor (CBF) genes. The CBF protein binds to the C-repeat/Dehydration Responsive Element (CRT/DRE), a homeopathic element of the Cold Regulated genes (COR gene) promoter, activating their transcription. Transcriptional regulations and post-translational modifications regulate and modify these entities at different response levels by altering their expression or activities in the signaling cascade. These activities then lead to efficient cold stress tolerance. This paper contains a concise summary of the ICE-CBF-COR pathway elucidating on the cross interconnections with other repressors, inhibitors, and activators to induce cold stress acclimation in plants.

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Section: Introductionmentioning

confidence: 99%

ICE-CBF-COR Signaling Cascade and Its Regulation in Plants Responding to Cold Stress

Hwarari

Guan

Ahmad

et al. 2022

IJMS

147

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“…Instead, it is the import of other activating factors that unlocks CBF activity. For instance, specific cytosolic thioredoxins respond to cold-induced oxidative bursts at the plasma membrane by nuclear import and cleave their sulphur bonds that have sequestered CBF oligomers that are then released and trigger the expression of COR genes [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Cold-Induced Nuclear Import of CBF4 Regulates Freezing Tolerance

Shi

Riemann

Rieger

et al. 2022

IJMS

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C-repeat binding factors (CBFs) are crucial transcriptional activators in plant responses to low temperature. CBF4 differs in its slower, but more persistent regulation and its role in cold acclimation. Cold acclimation has accentuated relevance for tolerance to late spring frosts as they have become progressively more common, as a consequence of blurred seasonality in the context of global climate change. In the current study, we explore the functions of CBF4 from grapevine, VvCBF4. Overexpression of VvCBF4 fused to GFP in tobacco BY-2 cells confers cold tolerance. Furthermore, this protein shuttles from the cytoplasm to the nucleus in response to cold stress, associated with an accumulation of transcripts for other CBFs and the cold responsive gene, ERD10d. This response differs for chilling as compared to freezing and is regulated differently by upstream signalling involving oxidative burst, proteasome activity and jasmonate synthesis. The difference between chilling and freezing is also seen in the regulation of the CBF4 transcript in leaves from different grapevines differing in their cold tolerance. Therefore, we propose the quality of cold stress is transduced by different upstream signals regulating nuclear import and, thus, the transcriptional activation of grapevine CBF4.

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“…Instead, it is the import of other activating factors that unlocks CBF activity. For instance, specific cytosolic thioredoxins respond to cold-induced oxidative burst at the plasma membrane by nuclear import and cleave their sulphur bonds that had sequestered CBF oligomers that are then released and trigger the expression of COR genes (Wi et al, 2022). Is shuttling of a transcription factor itself a specific feature delineating CBF4s, from the other CBFs?…”

Section: Discussionmentioning

confidence: 99%

“…Thus, an oxidative burst occurring at the plasma membrane is required for the cold-induced induction of COR transcripts happening in the nucleus. A molecular candidate for this transduction event might be thioredoxins such as AthTrx-h2 that translocate to the nucleus in response to an oxidative burst, unleashing there CBFs from sulphur bridge bondage (Wi et al ., 2022). A (non-intuitive) implication of this model would be that overexpression of VvCBF4 would stimulate the import of CBF4 under freezing stress amplifying the cold response of ERD10d transcripts ( Fig.…”

Section: Discussionmentioning

confidence: 99%

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Is cold-induced nuclear import of CBF4 regulating freezing tolerance?

Shi

Riemann

Marie

et al. 2022

Preprint

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C-repeat binding factors (CBFs) are crucial transcriptional activators in plant responses to low temperature. CBF4 differs by a slower, but more persistent regulation and its role in cold acclimation. Cold acclimation is of accentuated relevance for the tolerance to late spring frosts as they become progressively common as consequence of blurred seasonality in the context of global climate change. In the current study, we explore the functions of CBF4 from grapevine, VvCBF4. Overexpression of VvCBF4 fused to GFP in tobacco BY-2 cells confers cold tolerance. Furthermore, this protein shuttles from the cytoplasm to the nucleus in response to cold stress, associated with accumulation of transcripts for other CBFs and the cold responsive gene ERD10d. This response differs for chilling as compared to freezing and is regulated differently by upstream signalling involving oxidative burst, proteasome activity and jasmonate synthesis. This difference between chilling and freezing is also seen in the regulation of CBF4 transcripts in leaves from different grapevines differing in their cold tolerance. We propose a model, where the quality of cold stress is transduced by different upstream signals regulating nuclear import and, thus, transcriptional activation of grapevine CBF4.

show abstract

Redox‐mediated structural and functional switching of C‐repeat binding factors enhances plant cold tolerance

Cited by 12 publications

References 41 publications

ICE-CBF-COR Signaling Cascade and Its Regulation in Plants Responding to Cold Stress

ICE-CBF-COR Signaling Cascade and Its Regulation in Plants Responding to Cold Stress

Cold-Induced Nuclear Import of CBF4 Regulates Freezing Tolerance

Is cold-induced nuclear import of CBF4 regulating freezing tolerance?

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