Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity

Abstract

Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. OS plays a crucial role in the development of age-related diseases. In fact, damage due to oxidation depends strongly on the inherited or acquired defects of the redox-mediated enzymes. Molecular hydrogen (H2) has recently been reported to function as an anti-oxidant and anti-inflammatory agent for the treatment of several oxidative stress and aging-related diseases, including Alzheimer’s, Parkinson’s, cancer and osteoporosis. Additionally, H2 promotes healthy aging, increases the number of good germs in the intestine that produce more intestinal hydrogen and reduces oxidative stress through its anti-oxidant and anti-inflammatory activities. This review focuses on the therapeutic role of H2 in the treatment of neurological diseases. This review manuscript would be useful in knowing the role of H2 in the redox mechanisms for promoting healthful longevity.

Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment—Perspective View

“…H 2 has been demonstrated to possess anti-inflammatory, antioxidant, and anti-endoplasmic reticulum (ER) stress properties, and its involvement in the regulation of apoptosis, autophagy, and pyroptosis has been elucidated [12][13][14][15][16][17][18]. In this regard, H 2 can be considered a unique molecule that influences fundamental biological responses.…”

“…In this sense, excessive oxidative stress should be suppressed, but the degree of suppression should be at a level that does not compromise the benefits of reactive oxygen species to the body [15]. To date, while many preclinical studies using H 2 have confirmed organ-protective effects and correction of metabolic abnormalities through its antioxidant and anti-inflammatory effects [12][13][14][15][16][17][18], no severe side effects of H 2 loading have been observed. Therefore, the clinical application of antioxidant therapy with H 2 is considered a realistic challenge.…”

Structural characteristics of gut microbiota in longevity from Changshou town, Hubei, China

“…Longevity, as one of the most complex phenotypes, has intricate and unclear biological mechanisms and is closely associated with GM (Li and Roy 2023 ; Miller et al 2023 ; Coradduzza et al 2023 ; Rahman et al 2023 ). Although omics technologies have advanced the research on GM and longevity, there is still a lack of substantial data support in this field to further validate the microbiota biomarkers associated with longevity (Coradduzza et al 2023 ; Lee et al 2023 ; Miller et al 2023 ; Qiao et al 2023 ).…”

An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation

“…Hydrogen (H 2 ), which is emerging as a novel therapeutic agent, has demonstrated exceptional antioxidative and anti-inflammatory properties and holds significant promise for treating ROS-related diseases 16 - 18 . Its superior tissue and cell membrane permeability enable effective intratissue diffusion and targeting of organelles, including mitochondria and nuclei—the primary sources of ROS 19 .…”

“…H 2 can be instantly delivered to relieve oxidative stress by reacting with and detoxifying highly cytotoxic •OH without disrupting normal metabolic oxidation or cell signaling systems. This ability effectively suppresses inflammation and promotes tissue repair 18 . In addition to its therapeutic potential, hydrogen, as an endogenous inert gas, has been proven to be highly safe and biocompatible when administered through various methods, such as inhalation, drinking, intravenous or intraperitoneal injection, and in situ injection 18 , 20 , 21 .…”