Redox Flow Iontophoresis for Continuous Drug Delivery
Tobias E. Naegele,
Johannes Gurke,
Etienne Rognin
et al.
Abstract:Drug delivery into the brain and spinal cord is fundamentally limited by the blood‐brain barrier which impedes the use of the vast majority of drugs. Implants based on iontophoresis use an applied voltage to deliver charged drug molecules, allowing solvent‐free delivery directly into the site of interest and overcoming issues associated with systemic exposure to the drug. However, during continuous delivery over long periods, electrochemical reactions occur at the electrodes leading to corrosive gas formation.… Show more
Neurological conditions such as epilepsy can have a significant impact on people’s lives. Here, we discuss a new perspective for the study/treatment of these conditions using photopharmacology. A multimodal, intracranial...
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