Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects

Li, Ruirui; Peng, Feifei; Cai, Jinguang; Yang, Dandan; Zhang, Peng

doi:10.1016/j.ajps.2019.06.003

Cited by 85 publications

(41 citation statements)

References 84 publications

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“…The protein capping and the drug release strategy were also studied for transferrin-capped MSNs (DOX@MSNs-S-S-Tf), which showed cancer-targeting effects and released DOX through uncapping transferrin because of disulfide link destabilization. This specific system claims the slower release of the drug without GSH and rapid release in an intracellular state (Li et al, 2020). DOX-releasing nanoparticles were developed with MSNs coated with disulfide linkers to regulate the drug release in response to varying redox conditions.…”

Section: Redox-responsive Systemsmentioning

confidence: 99%

“…The generation and persistence of higher amounts of ROS was observed in cancer cells compared to normal cells due to the stimulation of different oncogenes, inflammation and mitochondrial damage (Li et al, 2020). A number of strategies have been developed for the design of ROSresponsive nanoparticle systems for cancer therapy by utilizing their physiochemical characteristics.…”

Section: Ros-responsive Systemsmentioning

confidence: 99%

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Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

Thomas

Surendran

Jeong

2020

Front. Mol. Biosci.

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Cancer is a disease that affects a large number of people all over the world. For treating cancer, nano-drug delivery system has been introduced recently with objective of increasing therapeutic efficiency of chemotherapeutic drug. The main characteristics of this system are the encapsulation of the insoluble chemotherapeutic cargo, increasing the period of circulation in the body, as well as the delivery of the drug at that specific site. Currently, the nano-drug delivery system based on the stimuli response is becoming more popular because of the extra features for controlling the drug release based on the internal atmosphere of cancer. This review provides a summary of different types of internal (pH, redox, enzyme, ROS, hypoxia) stimuli-responsive nanoparticle drug delivery systems as well as perspective for upcoming times.

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Section: Redox-responsive Systemsmentioning

confidence: 99%

Section: Ros-responsive Systemsmentioning

confidence: 99%

Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

Thomas

Surendran

Jeong

2020

Front. Mol. Biosci.

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“…Secondly, glutathione (GSH) plays a significant role in cellular growth, and its concentration is higher in the cytosol and nucleus than in the intracellular and extracellular fluids. Thus, it protects cells and hinders cellular apoptosis by oxidizing reactive oxygen species (ROS) (Li et al, 2019b ). Moreover, higher concentrations of GSH are detected (2–20 mM) in cancer cells compared to healthy cells which is responsible for tumor growth (Li et al, 2019b ).…”

Section: General Overview Of Internal and External Stimulimentioning

confidence: 99%

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Mohapatra

Uthaman

Park

2021

Front. Mol. Biosci.

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Therapeutic, diagnostic, and imaging approaches based on nanotechnology offer distinct advantages in cancer treatment. Various nanotherapeutics have been presented as potential alternatives to traditional anticancer therapies such as chemotherapy, radiotherapy, and surgical intervention. Notably, the advantage of nanotherapeutics is mainly attributable to their accumulation and targeting ability toward cancer cells, multiple drug-carrying abilities, combined therapies, and imaging approaches. To date, numerous nanoparticle formulations have been developed for anticancer therapy and among them, metallic nanotherapeutics reportedly demonstrate promising cancer therapeutic and diagnostic efficiencies owing to their dense surface functionalization ability, uniform size distribution, and shape-dependent optical responses, easy and cost-effective synthesis procedure, and multiple anti-cancer effects. Metallic nanotherapeutics can remodel the tumor microenvironment by changing unfavorable therapeutic conditions into therapeutically accessible ones with the help of different stimuli, including light, heat, ultrasound, an alternative magnetic field, redox, and reactive oxygen species. The combination of metallic nanotherapeutics with both external and internal stimuli can be used to trigger the on-demand release of therapeutic molecules, augmenting the therapeutic efficacies of anticancer therapies such as photothermal therapy, photodynamic therapy, magnetic hyperthermia, sonodynamic therapy, chemodynamic therapy, and immunotherapy. In this review, we have summarized the role of different metallic nanotherapeutics in anti-cancer therapy, as well as their combinational effects with multiple stimuli for enhanced anticancer therapy.

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“…Introducing a stimuli-sensitive linker between two bioactive molecules is an additional advantageous approach to upgrade the prodrug delivery system, which allows rapid drug release due to being triggered by specified stimuli [20,21]. A stimuli-responsive system is an extensively studied method to trigger the release of active drugs from prodrugs [22][23][24]. Interestingly, the tumor cell microenvironment has unique physiological characteristics that are crucial for the development of the stimuli-responsive system.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, the tumor cell microenvironment has unique physiological characteristics that are crucial for the development of the stimuli-responsive system. Indeed, tumor cell microenvironment possess redox-, acidic-pH-, enzyme-, and reactive oxygen species (ROS)-responsive characteristics [22]. Redox-responsiveness is used for targeting tumor tissue due to the higher concentration of glutathione (GSH) and ROS, such as hydrogen peroxide (H 2 O 2 ) in tumor intracellular compartment (~2-10 mM) than that in normal tissue (~2-20 µM) [25].…”

Section: Introductionmentioning

confidence: 99%

Redox-Responsive Heparin–Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity

et al. 2019

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Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient therapy. In this study, redox-responsive disulfide bond-containing amphiphilic heparin–chlorambucil conjugated polymeric prodrugs were designed and synthesized to enhance anti-tumor activities of chlorambucil. The conjugated prodrug could be self-assembled to form spherical vesicles with 61.33% chlorambucil grafting efficiency. The cell viability test results showed that the prodrug was biocompatible with normal cells (HaCaT) and that it selectively killed tumor cells (HeLa cells). The uptake of prodrugs by HeLa cells increased with time. Therefore, the designed prodrugs can be a better alternative as delivery vehicles for the chlorambucil controlled release in cancer cells.

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Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects

Cited by 85 publications

References 84 publications

Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Redox-Responsive Heparin–Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity

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