Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery

Cheng, Cheng; Ma, Jiayun; Zhao, Jinling; Lu, Haiying; Liu, Yang; He, Chuanshi; Lu, Mengji; Yin, Xiaoxing; Li, Jianshu; Ding, Mingming

doi:10.1039/d2tb02686d

Cited by 8 publications

(9 citation statements)

References 49 publications

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“…Future studies should employ enhanced sampling to investigate the permeability of various drugs through polymer membranes, similar to those simulated for cell membranes . In addition, most drug release simulation studies have focused on single drug release, with few investigations on the dynamic co-release and sequential release processes that have been achieved experimentally by using multicompartment polymersomes, “traceless cross-linking” strategy, and redox-dual-response multiblock polymersomes …”

Section: Drug Encapsulation and Releasementioning

confidence: 99%

Polymersomes in Drug Delivery─From Experiment to Computational Modeling

Xu,

Wang,

Zheng

et al. 2023

Biomacromolecules

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Polymersomes, composed of amphiphilic block copolymers, are self-assembled vesicles that have gained attention as potential drug delivery systems due to their good biocompatibility, stability, and versatility. Various experimental techniques have been employed to characterize the self-assembly behaviors and properties of polymersomes. However, they have limitations in revealing molecular details and underlying mechanisms. Computational modeling techniques have emerged as powerful tools to complement experimental studies and enabled researchers to examine drug delivery mechanisms at molecular resolution. This review aims to provide a comprehensive overview of the state of the art in the field of polymersome-based drug delivery systems, with an emphasis on insights gained from both experimental and computational studies. Specifically, we focus on polymersome morphologies, self-assembly kinetics, fusion and fission, behaviors in flow, as well as drug encapsulation and release mechanisms. Furthermore, we also identify existing challenges and limitations in this rapidly evolving field and suggest possible directions for future research.

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Section: Drug Encapsulation and Releasementioning

confidence: 99%

Polymersomes in Drug Delivery─From Experiment to Computational Modeling

Xu,

Wang,

Zheng

et al. 2023

Biomacromolecules

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“…[8,[11][12][13] Traditionally, the morphologies (shape and size) of BCP self-assemblies are primarily determined by the overall degree of polymerization, which is proportional to the molecular weight, and by the chemical composition of the copolymer, which corresponds to the volume fractions of hydrophobic and hydrophilic blocks. [14][15][16] But if we think about adding amino acids with excellent structural properties and biocompatibility to the BCP backbone, creating so-called synthetic polypeptides, we can obtain an additional controlling factor of self-assembly behaviors: secondary conformation. [17][18][19][20][21][22] As is widely known, the folding of proteins made of natural amino acids is essential to all biological processes of life and has been designed for a variety of biological functions such as catalysis, cell support, and signal transduction.…”

Section: Introductionmentioning

confidence: 99%

“…[39] By means of intermolecular and/or intramolecular interactions, PAAs with precise folding and stable conformations provide a novel way to determine the formation of nanoscale configurations. [15,[40][41][42][43][44][45][46] Compared with their disordered analogues, synthetic PAAs with ordered secondary structures, in general, have several advantageous properties, such as defined morphology or improved stability. [16,19,[47][48][49] This is highly beneficial to the application of nanoparticles in many biomedical fields.…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembly of Poly(Amino Acid)s Mediated by Secondary Conformations

Zheng

Yan

et al. 2023

ChemBioChem

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Self‐assembly of block copolymers has recently drawn great attention due to its remarkable performance and wide variety of applications in biomedicine, biomaterials, microelectronics, photoelectric materials, catalysts, etc. Poly(amino acid)s (PAAs), formed by introducing synthetic amino acids into copolymer backbones, are able to fold into different secondary conformations when compared with traditional amphiphilic copolymers. Apart from changing the chemical composition and degree of polymerization of copolymers, the self‐assembly behaviors of PAAs could be controlled by their secondary conformations, which are more flexible and adjustable for fine structure tailoring. In this article, we summarize the latest findings on the variables that influence secondary conformations, in particular the regulation of order‐to‐order conformational changes and the approaches used to manage the self‐assembly behaviors of PAAs. These strategies include controlling pH, redox reactions, coordination, light, temperature, and so on. Hopefully, we can provide valuable perspectives that will be useful for the future development and use of synthetic PAAs.

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“…[25] Light trigger as an external stimulus is non-invasive, site-specific, and can be applied with high spatial and temporal manner, [26][27][28][29][30][31] which has found vast applications in controlled drug release systems. [27][28][29][32][33][34] Despite that a variety of polypeptides capable of changing their conformations in response to light irradiation have been extensively explored, [35][36][37][38][39][40][41][42] most of these polymers have been functionalized with cumbersome photochromic groups. To date, light-modulated order-to-order conformation transitions in non-photosensitive polymers have not been reported.…”

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confidence: 99%

Photoallosteric Polymersomes toward On‐Demand Drug Delivery and Multimodal Cancer Immunotherapy

Zheng

Liu

et al. 2023

Advanced Materials

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Allosteric transitions can modulate the self‐assembly and biological function of proteins. It remains, however, tremendously challenging to design synthetic allosteric polymeric assemblies with spatiotemporally switchable hierarchical structures and functionalities. Here, a photoallosteric polymersome is constructed that undergoes a rapid conformational transition from β‐sheet to α‐helix upon exposure to near‐infrared light irradiation. In addition to improving nanoparticle cell penetration and lysosome escape, photoinduced allosteric behavior reconstructs the vesicular membrane structure, which stimulates the release of hydrophilic cytolytic peptide melittin and hydrophobic kinase inhibitor sorafenib. Combining on‐demand delivery of multiple therapeutics with phototherapy results in apoptosis and immunogenic death of tumor cells, remold the immune microenvironment and achieve an excellent synergistic anticancer efficacy in vivo without tumor recurrence and metastasis. Such a light‐modulated allosteric transition in non‐photosensitive polymers provides new insight into the development of smart nanomaterials for biosensing and drug delivery applications.

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Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery

Abstract: Based on disulfide-enriched multiblock copolymer vesicles, we present a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX·HCl) and hydrophobic paclitaxel (PTX) under oxidative and...

Cited by 8 publications

References 49 publications

Polymersomes in Drug Delivery─From Experiment to Computational Modeling

Polymersomes in Drug Delivery─From Experiment to Computational Modeling

Self‐Assembly of Poly(Amino Acid)s Mediated by Secondary Conformations

Photoallosteric Polymersomes toward On‐Demand Drug Delivery and Multimodal Cancer Immunotherapy

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