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Cited by 386 publications
(347 citation statements)
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References 378 publications
(562 reference statements)
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“…Indeed, there is also evidence that oncogenes actively up-regulate antioxidant mechanisms to avoid this fate (34). There has recently been extensive focus on exploring ways to exploit the altered redox state of tumor cells through the use of pro-oxidant therapies, thus far with limited success, at least as monotherapy (35)(36)(37). Mitochondria are the major source of ROS in most cells and are highly dependent on mitochondrial antioxidant defenses, such as glutathione peroxidase (about one third of glutathione peroxidase is mitochondrial) to avoid their deleterious effects (38).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, it is still under debate whether ROS decrease or increase may be more beneficial for the treatment of cancer. Cancer cells may either be affected by the accumulation of ROS above a cytotoxic threshold, or by the inhibition of ROS below a concentration, which is essential for signaling processes (10). Thereby, we assume that the upregulation of ROS may not be the preferred approach, as it may severely affect normal cells.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, there is the need to develop minimally toxic substances to treat patients with highgrade-non-Hodgkin lymphoma efficiently. A novel class of promising chemotherapeutics is the group of reactive oxygen species (ROS)-modulating substances (10). The analysis of ROS and their involvement in the initiation and maintenance of malignancies is an emerging topic in cancer research (11,12).…”
Section: Introductionmentioning
confidence: 99%
“…Importantly, this dependency might not be shared by many nontransformed cells, whose lower basal ROS levels and/or elevated antioxidant capacity could provide resistance to treatments that impair ROS metabolism. In keeping with this hypothesis, various small molecules, including ones with disulfide, α,β-unsaturated carbonyl, sulfonate, or other electrophilic functional groups, have previously been shown to elevate ROS levels and induce cancer cell death (6). A subset of such compounds has also demonstrated a degree of selective toxicity toward cancer cells in in vitro and in vivo models (7)(8)(9)(10)(11)(12).…”
mentioning
confidence: 94%
“…In humans, there are two thioredoxins, thioredoxin 1 (hTrx1), which is found in the cytosol and the nucleus, and thioredoxin 2 (hTrx2), which is targeted to the mitochondria. hTrx1 is increasingly implicated in the regulation of many complex diseases and physiological processes, including cancer, 3,4 cardiovascular disease, 5 and aging. 6 hTrx1 has three cysteines, Cys 62, Cys 69, and Cys 73, in addition to the active site dithiol pair (Cys 32 and Cys 35).…”
Section: Introductionmentioning
confidence: 99%