Redox Cycling Realized in Paper-Based Biochemical Sensor for Selective Detection of Reversible Redox Molecules Without Micro/Nano Fabrication Process

Yamamoto, So; Uno, Shigeyasu

doi:10.3390/s18030730

Cited by 17 publications

(11 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yamamoto et al recently reported redox cyling in a paper-based device. 33 Yet, the experiment was limited to only a pair of electrodes. In this work, a new PON detection platform is designed by coupling TPE arrays, consisting of up to 8 electrodes, into a flow-based ePAD.…”

mentioning

confidence: 99%

“…IDAs are very rarely used as low cost-PON sensors as they are limited by expensive conventional fabrication techniques, such as photolithography and chemical vapor deposition. , A few studies have adapted IDAs into PADs via chemical deposition and gravure printing. , However, their use was limited to resistance-based measurements, with no redox-based electrochemistry performed. Yamamoto et al recently reported redox cyling in a paper-based device . Yet, the experiment was limited to only a pair of electrodes.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Thermoplastic Electrode Arrays in Electrochemical Paper-Based Analytical Devices

et al. 2019

View full text Add to dashboard Cite

Electrochemical paper-based analytical devices (ePADs) have garnered significant interest as an alternative to traditional benchtop methods due to their low cost and simple fabrication. Historically, ePADs have relied almost exclusively on single electrode detection, limiting potential gains in sensitivity and selectivity achievable with multiple electrodes. Herein we describe incorporation of thermoplastic electrode (TPE) arrays into flow ePADs. Quasi-steady flow was solely generated by capillary action through a fan-shaped paper device. The electrode arrays were fabricated using a simple solvent-assisted method with inexpensive materials (i.e., graphite and thermoplastic binder). These electrodes can be employed as an array of individually addressable detectors or connected as an interdigitated electrode array. The TPEs were characterized through SEM, optical profilometry and cyclic voltammetry. Chronoamperometry was used to characterize the flow-based TPE-ePADs. Trace detection of a ferrocene complex (FcTMA + ) was demonstrated through generation-collection experiments, achieving a limit of detection of 0.32 pmol. These TPE arrays containing ePADs show great promise as a rapid, sensitive, and low-cost sensor for point-of-need (PON) applications.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Thermoplastic Electrode Arrays in Electrochemical Paper-Based Analytical Devices

et al. 2019

View full text Add to dashboard Cite

show abstract

“…3C [79,94]. This electrode assembling configuration is highly attractive for implementation with reversible redox markers as the distance between the two electrodes defined by the thickness of thin-layer paper could be sufficiently small for redox cycling [95].…”

Section: External Electrodesmentioning

confidence: 99%

Integrating high-performing electrochemical transducers in lateral flow assay

Perju

Wongkaew

2021

Anal Bioanal Chem

View full text Add to dashboard Cite

Lateral flow assays (LFAs) are the best-performing and best-known point-of-care tests worldwide. Over the last decade, they have experienced an increasing interest by researchers towards improving their analytical performance while maintaining their robust assay platform. Commercially, visual and optical detection strategies dominate, but it is especially the research on integrating electrochemical (EC) approaches that may have a chance to significantly improve an LFA’s performance that is needed in order to detect analytes reliably at lower concentrations than currently possible. In fact, EC-LFAs offer advantages in terms of quantitative determination, low-cost, high sensitivity, and even simple, label-free strategies. Here, the various configurations of EC-LFAs published are summarized and critically evaluated. In short, most of them rely on applying conventional transducers, e.g., screen-printed electrode, to ensure reliability of the assay, and additional advances are afforded by the beneficial features of nanomaterials. It is predicted that these will be further implemented in EC-LFAs as high-performance transducers. Considering the low cost of point-of-care devices, it becomes even more important to also identify strategies that efficiently integrate nanomaterials into EC-LFAs in a high-throughput manner while maintaining their favorable analytical performance.

show abstract

“…[8] The redox cycling system is also a powerful strategy to enable discrimination of redox species with different reaction characteristics since currents from chemically irreversible redox reactions are not being amplified. [9,10] Various electrode configurations and designs, both lateral and vertical approaches, have been reported and achieved very good signal amplification efficiencies. [11] Interdigitated electrodes (IDEs) in an array format are one of the most popular configurations due to their simplicity in terms of design and manufacturing.…”

Section: Introductionmentioning

confidence: 99%

Laser‐Induced Carbon Nanofiber‐Based Redox Cycling System

Perju,

Wongkaew

2023

ChemElectroChem

View full text Add to dashboard Cite

Redox cycling is a powerful amplification strategy for reversible redox species within miniaturized electrochemical sensors. Herein, we generate three‐dimensional (3D) porous carbon nanofiber electrodes by CO2 laser‐writing on electrospun polyimide (PI) nanofiber mats, referred to as laser‐induced carbon nanofibers (LCNFs). The technique allowed the fabrication of interdigitated electrode (IDE) arrays with finger width and gap distance of ~400 μm and ~40 μm, respectively, offering approximately 3.5 times amplification efficiency (AF) and 95 % collection efficiency (CE). Such dimensions could not be achieved with IDEs fabricated on conventional PI film because the devices were short‐circuited. Stacked electrodes were also constructed as an alternative to the IDE design. Here, nanofiber mats as thin as ~20 μm were fabricated and used as vertical insulation between two LCNF band electrodes. While redox cycling efficiency was similar, the IDE design is more favorable considering the lower complexity and better signal reproducibility. Our strategy thus paves the way for creating flexible 3D porous electrodes with redox cycling ability that can be integrated into microfluidics and lab‐on‐a‐chip systems. In particular, the devices offer inherent flow‐through features in miniaturized analytical devices where separation and sensitive detection could be further realized.

show abstract

Redox Cycling Realized in Paper-Based Biochemical Sensor for Selective Detection of Reversible Redox Molecules Without Micro/Nano Fabrication Process

Cited by 17 publications

References 43 publications

Thermoplastic Electrode Arrays in Electrochemical Paper-Based Analytical Devices

Thermoplastic Electrode Arrays in Electrochemical Paper-Based Analytical Devices

Integrating high-performing electrochemical transducers in lateral flow assay

Laser‐Induced Carbon Nanofiber‐Based Redox Cycling System

Contact Info

Product

Resources

About