Redox Chemistry of Nickel Complexes in Aqueous Solutions

Zilbermann, Israel; Maimon, Eric; Cohen, Haim; Meyerstein, Dan

doi:10.1021/cr030717f

Cited by 96 publications

(64 citation statements)

References 211 publications

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“…Ascorbate was chosen as the reducing agent as the kinetics and the mechanism of the reaction have already been reported in detail. [6,7,9] This reaction proceeds through two consecutive single-electron steps, in which the first step follows an outer-sphere mechanism and is rate-determining.…”

Section: Electron Exchange Columnmentioning

confidence: 99%

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Electron Exchange Columns through Entrapment of a Nickel Cyclam in a Sol–Gel Matrix

Lavi

Burg

Maimon

et al. 2011

Chemistry A European J

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An electron exchange column (analogous to ion exchange columns) was developed using the unique redox properties of the nickel-tetraazamacrocyclic complexes (nickel cyclam [Ni(II)L(1)](2+)) and nickel-trans-III-meso-5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, ([Ni(II)L(2)](2+)), and the physical and chemical stability of the ceramic materials using the sol-gel process to entrap the complexes. The entrapment by the biphasic sol-gel method is based on non-covalent bonds between the matrix and the complex; therefore the main problem was leaching. Parameters controlling the leaching were investigated. Redox cycles with the reducing agent ascorbic acid, and persulfate as the oxidizing agent were performed.

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Section: Electron Exchange Columnmentioning

confidence: 99%

“…[9] However, both complexes are very strong oxidizing agents towards ascorbate. Thus it is not surprising that the yield of oxidation is similar in both systems and is determined by the availability of the complex to the reducing agent, that is, to the location in the matrix where the complex is entrapped.…”

Section: Electron Exchange Columnmentioning

confidence: 99%

Electron Exchange Columns through Entrapment of a Nickel Cyclam in a Sol–Gel Matrix

Lavi

Burg

Maimon

et al. 2011

Chemistry A European J

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“…12 Hz. The 1 H NMR spectra for nickel complexes 1-4 are much simpler than those of their macrocyclic analogues (5)(6)(7)(8). [14] This is most likely due to the absence of the structural rigidness, as the chelate rings invert much more rapidly, which results in a simple time-averaged spectrum.…”

Section: Nmr Spectral Studiesmentioning

confidence: 99%

“…In this context, designed organic ligands hold potential with the unique ability to modulate the redox chemistry of the nickel ion. [8] The ligand architecture and its mode of coordination [9] is an important factor responsible for the redox regulation of a metal centre, and the present work is an attempt to understand the effect of the macrocyclic versus open-chain nature of the ligands on the structure and redox chemistry of the nickel ion.…”

Section: Introductionmentioning

confidence: 99%

Studies on Nickel(II) Complexes with Amide‐Based Ligands: Syntheses, Structures, Electrochemistry and Oxidation Chemistry

2008

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The present work discusses the nickel chemistry in a set of amide-based open-chain ligands with subtle differences in the backbone or terminal amine substituents. The ligands coordinate to the Ni 2+ ion through the N amide and N amine atoms maintaining a square-planar geometry. Absorption spectra and NMR studies reveal that the solid-state square-planar geometry is retained in solution. The electrochemical results suggest that the Ni III /Ni II redox couple primarily depends on the N 4 donors, which is composed of two N amide and two N amine atoms and not on the peripheral substituents. All four ligands with variable backbone and substituents are equally

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“…Although MT can also protect against other reactive oxygen species, such as superoxide and hydrogen peroxide (30), Zn-MT, the major cellular form of MT in vivo, may not function as effectively as MT in scavenging reactive oxygen species. Nickel has been shown to cause mild oxidative stress at high concentrations (31), but there is little evidence that ionic nickel (Ni 2ϩ ) directly participates in redox cycling that could generate reactive oxygen species in the lung (32). It is also unlikely that the protective effects of MT involve the direct sequestration of nickel by MT because MT has a low affinity for nickel as compared with other metals (33).…”

Section: Mt Induction Leads To Protection During Acute Lung Injurymentioning

confidence: 99%

The Role of Metallothionein in the Pathogenesis of Acute Lung Injury

Wesselkamper

McDowell²,

Medvedovic³

et al. 2006

Am J Respir Cell Mol Biol

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Often fatal, acute lung injury has a complicated etiology. Previous studies from our laboratory in mice have demonstrated that survival during acute lung injury is a complex trait governed by multiple loci. We also found that the increase in metallothionein (MT) is one of the greatest noted in transcriptome-wide analyses of gene expression. To assess the role of MT in nickel-induced acute lung injury, the survival of Mt-transgenic, Mt1/2 (ϩ/ϩ) , and Mt1/2 (Ϫ/Ϫ) mice was compared. Pulmonary inflammation and global gene expression were compared in Mt1/2 (ϩ/ϩ) and Mt1/2 (Ϫ/Ϫ) mice. Genetargeted Mt1/2 (Ϫ/Ϫ) mice were more susceptible than Mt1/2 (ϩ/ϩ) mice to nickel-induced inflammation, surfactant-associated protein B transcript loss, and lethality. Similarly, Mt-transgenic mice exhibited increased survival. MAPPFinder analyses also noted significant decreases in genes involved in protein processing (e.g., ubiquitination, folding), which were greater in Mt1/2 (Ϫ/Ϫ) mice as compared with Mt1/2 (ϩ/ϩ) mice early in the progression of acute lung injury, possibly due to a zinc-mediated transcript destabilization. In contrast, transcript levels of genes associated with the inflammatory response, extracellular matrix regulation, and coagulation/fibrinolysis were increased more in Mt1/2 (Ϫ/Ϫ) mice as compared with Mt1/2 (ϩ/ϩ) mice late in the development of acute lung injury. Thus, MT ultimately improves survival in the progression of acute lung injury in mice. Transcriptome-wide analysis suggests that this survival may be mediated through changes in the destabilization of transcripts associated with protein processing, the subsequent augmentation of transcripts controlling inflammation, extracellular matrix regulation, coagulation/fibrinolysis, and disruption of surfactant homeostasis.

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Redox Chemistry of Nickel Complexes in Aqueous Solutions

Cited by 96 publications

References 211 publications

Electron Exchange Columns through Entrapment of a Nickel Cyclam in a Sol–Gel Matrix

Electron Exchange Columns through Entrapment of a Nickel Cyclam in a Sol–Gel Matrix

Studies on Nickel(II) Complexes with Amide‐Based Ligands: Syntheses, Structures, Electrochemistry and Oxidation Chemistry

The Role of Metallothionein in the Pathogenesis of Acute Lung Injury

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