Rediscovering the Schulze−Hardy Rule in Competitive Adsorption to an Air−Water Interface

Stenger, Patrick C.; Isbell, Stephen G.; Hillaire, Debra St.; Zasadzinski, Joseph A.

doi:10.1021/la9009724

Cited by 18 publications

(55 citation statements)

References 69 publications

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“…Da Silva et al [62] have shown that serum proteins leaking into a ventilated rat lung led to significant decreases in surfactant performance and lung compliance; the effects on the surfactant were less when the lung was flushed to remove blood and reduce cholesterol. In vitro , there is an ARDS-like depression of LS activity when serum proteins are added to a LS-covered interface [68–70, 74, 78], LS is added to a serum-covered interface [13, 79–84] or both LS and serum proteins are presented simultaneously [85–87]. …”

Section: Surfactant Inactivationmentioning

confidence: 99%

Overcoming rapid inactivation of lung surfactant: Analogies between competitive adsorption and colloid stability

Zasadzinski

Stenger

Shieh

et al. 2010

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Lung surfactant (LS) is a mixture of lipids and proteins that line the alveolar air-liquid interface, lowering the interfacial tension to levels that make breathing possible. In acute respiratory distress syndrome (ARDS), inactivation of LS is believed to play an important role in the development and severity of the disease. This review examines the competitive adsorption of LS and surface-active contaminants, such as serum proteins, present in the alveolar fluids of ARDS patients, and how this competitive adsorption can cause normal amounts of otherwise normal LS to be ineffective in lowering the interfacial tension. LS and serum proteins compete for the air-water interface when both are present in solution either in the alveolar fluids or in a Langmuir trough. Equilibrium favors LS as it has the lower equilibrium surface pressure, but the smaller proteins are kinetically favored over multi-micron LS bilayer aggregates by faster diffusion. If albumin reaches the interface, it creates an energy barrier to subsequent LS adsorption that slows or prevents the adsorption of the necessary amounts of LS required to lower surface tension. This process can be understood in terms of classic colloid stability theory in which an energy barrier to diffusion stabilizes colloidal suspensions against aggregation. This analogy provides qualitative and quantitative predictions regarding the origin of surfactant inactivation. An important corollary is that any additive that promotes colloid coagulation, such as increased electrolyte concentration, multivalent ions, hydrophilic non-adsorbing polymers such as PEG, dextran, etc. or polyelectrolytes such as chitosan, added to LS, also promotes LS adsorption in the presence of serum proteins and helps reverse surfactant inactivation. The theory provides quantitative tools to determine the optimal concentration of these additives and suggests that multiple additives may have a synergistic effect. A variety of physical and chemical techniques including isotherms, fluorescence microscopy, electron microscopy and X-ray diffraction show that LS adsorption is enhanced by this mechanism without substantially altering the structure or properties of the LS monolayer.

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Section: Surfactant Inactivationmentioning

confidence: 99%

Overcoming rapid inactivation of lung surfactant: Analogies between competitive adsorption and colloid stability

Zasadzinski

Stenger

Shieh

et al. 2010

Biochimica et Biophysica Acta (BBA) - Biomembranes

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“…Both counterions and coions can be subjected to specific adsorption on the surface of colloidal parti cles, which must undoubtedly be reflected in the char acter of coagulation of sols and suspensions. Among the large number of experimental and theoretical stud ies of slow and fast coagulation, there are only scarce literature data on the effects coions (including double and triple charged) on coagulation processes [3][4][5][6][7]. The lack of systematic investigations in this field poses the problem of obtaining reliable experimental data and finding the main regularities of the influence of coions on coagulation.…”

Section: Introductionmentioning

confidence: 99%

Photometric study of the kinetics of TiO2 hydrosol coagulation in electrolyte solutions

2012

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“…3). 71 It would obviously be impracticable to use high levels of saline because of their osmotic effect on lung tissue. However, it has been calculated (using the Schulze-Hardy rule) that divalent calcium would enhance surfactant adsorption at concentrations 2 À6 lower than monovalent sodium.…”

Section: Electrolytes-decreasing Debye Lengthmentioning

confidence: 99%

“…It was experimentally verified that CaCl 2 concentrations of B15-20 mM would be sufficient to overcome albumin adsorption and would have minimal effects on the fluid balance in a rat lung. 71 …”

Section: Electrolytes-decreasing Debye Lengthmentioning

confidence: 99%

Overcoming inactivation of the lung surfactant by serum proteins: a potential role for fluorocarbons?

Krafft

2015

Soft Matter

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In many pulmonary conditions serum proteins interfere with the normal adsorption of components of the lung surfactant to the surface of the alveoli, resulting in lung surfactant inactivation, with potentially serious untoward consequences. Here, we review the strategies that have recently been designed in order to counteract the biophysical mechanisms of inactivation of the surfactant. One approach includes protein analogues or peptides that mimic the native proteins responsible for innate resistance to inactivation. Another perspective uses water-soluble additives, such as electrolytes and hydrophilic polymers that are prone to enhance adsorption of phospholipids. An alternative, more recent approach consists of using fluorocarbons, that is, highly hydrophobic inert compounds that were investigated for partial liquid ventilation, that modify interfacial properties and can act as carriers of exogenous lung surfactant. The latter approach that allows fluidisation of phospholipid monolayers while maintaining capacity to reach near-zero surface tension definitely warrants further investigation.

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Rediscovering the Schulze−Hardy Rule in Competitive Adsorption to an Air−Water Interface

Cited by 18 publications

References 69 publications

Overcoming rapid inactivation of lung surfactant: Analogies between competitive adsorption and colloid stability

Overcoming rapid inactivation of lung surfactant: Analogies between competitive adsorption and colloid stability

Photometric study of the kinetics of TiO2 hydrosol coagulation in electrolyte solutions

Overcoming inactivation of the lung surfactant by serum proteins: a potential role for fluorocarbons?

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