Redirecting Tumor Evolution with Nanocompiler Precision for Enhanced Therapeutic Outcomes
Wenshe Sun,
Biao Cai,
Zejun Zhao
et al.
Abstract:Precisely programming the highly plastic tumor expression profile to render it devoid of drug resistance and metastatic potential presents immense challenges. Here, a transformative nanocompiler designed to reprogram and stabilize the mutable state of tumor cells is introduced. This nanocompiler features a trio of components: 2‐deoxy‐d‐glucose‐modified lipid nanoparticles to inhibit glucose uptake, iron oxide nanoparticles to induce oxidative stress, and a deubiquitinase inhibitor to block adaptive protein pro… Show more
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