Redetermined structure of gossypol (P3 polymorph)

Abstract

An improved crystal structure of the title compound, C30H30O8 (systematic name: 1,1′,6,6′,7,7′-hexa­hydroxy-5,5′-diisopropyl-3,3′-dimeth­yl[2,2′-bi­naphthalene]-8,8′-dicarbaldehyde), was determined based on modern CCD data. Compared to the previous structure [Talipov et al. (1985). Khim. Prirod. Soedin. (Chem. Nat. Prod.), 6, 20–24], geometrical precision has been improved (typical C—C bond-distance s.u. = 0.002 Å in the present structure compared to 0.005 Å in the previous structure) and the locations of several H atoms have been corrected. The gossypol mol­ecules are in the aldehyde tautomeric form and the dihedral angle between the naphthyl fragments is 80.42 (4)°. Four intra­molecular O—H⋯O hydrogen bonds are formed. In the crystal, inversion dimers with graph-set motif R 2 2(20) are formed by pairs of O—H⋯O hydrogen bonds; another pair of O—H⋯O hydrogen bonds with the same graph-set motif links the dimers into [001] chains. The packing of such chains in the crystal leads to the formation of channels (diameter = 5–8 Å) propagating in the [101] direction. The channels presumably contain highly disordered solvent mol­ecules; their contribution to the scattering was removed with the SQUEEZE [Spek (2015). Acta Cryst. C71, 9–18] routine in PLATON and the stated mol­ecular mass, density etc., do not take them into account.

Luminescence “Turn-On” Detection of Gossypol Using Ln3+-Based Metal–Organic Frameworks and Ln3+ Salts

“…Crystal structures of Yb-NH 2 -TPDC and Gsp . (A) Synthesis scheme for Yb-NH 2 -TPDC (C, gray spheres; O, red spheres; N, blue spheres, Yb, teal polyhedra; H, omitted for clarity).…”