Redefinition of Tuberculosis‐Associated Immune Reconstitution Syndromes in HIV‐Infected Individuals: A Need for New Clinical Tools

Reyes-Corcho, Andrés; Bouza-Jiménez, Yadira

doi:10.1086/649820

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Diagnosis of paradoxical TB-IRIS is complicated by the lack of confirmatory diagnostic tests [87]. Opportunistic infections, malignancies and drug resistance have to be excluded during assesment.…”

Section: Tuberculosis Immune Reconstitution Inflammatory Syndrome (Tbmentioning

confidence: 99%

Highly Active Antiretroviral Therapy and Anti-tuberculosis Drug Interactions with Associated Clinical Implications: A Review

Jk¹,

Ng²

2016

J Drug Metab Toxicol

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Tuberculosis is the most common opportunistic infection associated with HIV/AIDS, and remains a disease of global significance. Co-infection with HIV complicates proper TB diagnosis and therapeutic outcomes. Profound immunosuppression characterizes HIV/TB co-infection prompting early initiation of HAART during TB treatment. Effective management of the co-infection requires concomitant administration of ART and anti-tuberculosis drugs; however, this therapeutic approach has had its fair share of challenges including: overlapping drug toxicities, drugdrug interactions and immune reconstitution reactions. For instance, combination of nevirapine-based ART and rifampicin-based TB treatment is reported to cause hepatotoxicity in healthy volunteers. As such, this review compiles information from multiple studies describing drug interactions associated with co-treatments, with a view to improving management of these co-morbidities.

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Section: Tuberculosis Immune Reconstitution Inflammatory Syndrome (Tbmentioning

confidence: 99%

Highly Active Antiretroviral Therapy and Anti-tuberculosis Drug Interactions with Associated Clinical Implications: A Review

Jk¹,

Ng²

2016

J Drug Metab Toxicol

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“…[3] Currently, the lack of controlled clinical trials and specific confirmatory diagnostic tests, as well as the broad clinical spectrum of TB-IRIS, make this syndrome a real challenge for clinicians. [4] The incidence of TB-IRIS is expected to increase in low resource, high TB. and HIV burden countries like sub-Saharan Africa as more patients are started on HAART and the fact that the majority of HIV-infected patients present late with profound immunosuppresssion and increased risk for TB-IRIS.…”

mentioning

confidence: 99%

Tuberculosis-associated immune reconstitution inflammatory syndrome: Management challenges in resource-limited settings

Adeiza¹

2012

Ann Nigerian Med

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Immune Reconstitution Inflammatory Syndrome in HIV-Positive Patients: A Relatively New and Not Fully Understood Phenomenon

Arendt

Nolting

2010

HIV Ther.

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Redefinition of Tuberculosis‐Associated Immune Reconstitution Syndromes in HIV‐Infected Individuals: A Need for New Clinical Tools

Cited by 3 publications

References 5 publications

Highly Active Antiretroviral Therapy and Anti-tuberculosis Drug Interactions with Associated Clinical Implications: A Review

Highly Active Antiretroviral Therapy and Anti-tuberculosis Drug Interactions with Associated Clinical Implications: A Review

Tuberculosis-associated immune reconstitution inflammatory syndrome: Management challenges in resource-limited settings

Immune Reconstitution Inflammatory Syndrome in HIV-Positive Patients: A Relatively New and Not Fully Understood Phenomenon

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