Redefining the impact of nutrition on breast cancer incidence: is epigenetics involved?

Teegarden, Dorothy; Romieu, Isabelle; Lelièvre, Sophie A.

doi:10.1017/s0954422411000199

Cited by 46 publications

(74 citation statements)

References 297 publications

(350 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, one-carbon metabolism can impact both genetic and epigenetic procarcinogenic processes, and these biological roles potentially make folate and other related B vitamins significant in cancer prevention 45 .…”

Section: B Vitamins Folatementioning

confidence: 99%

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

Romieu

Amadou

Chajès

2017

RIC

View full text Add to dashboard Cite

The incidence of breast cancer (BC) is rising worldwide, with an increase in aggressive neoplasias in young women. Traditionally, BC in young women has been thought to be etiologically driven, primarily by genetic/hereditary factors. However, these factors explain only a small proportion of BCs, pointing to a role of the environment. Suspected factors responsible for this increase include lifestyle changes, notably alcohol consumption, diet with high intake of refined carbohydrates and saturated fat and low intake of polyunsaturated fatty acids (PUFA), fiber and vitamins (such as folate, vitamin D, and carotenoids), low physical activity, and body fatness, all of which may act from childhood and adolescent years through adulthood. Despite limited data on BC in young women, evidence points to the importance of a healthy lifestyle, including high intake of vegetables, fruits, legumes, fish, and poultry, low intake of sugar and fat, daily physical activity, low alcohol consumption, steady weight, and breastfeeding in preventing BC in young women. Preventive efforts should begin in early life to provide important benefits much later in life by shifting the long-term trajectory of risk accumulation. Data from Latin America and developing regions are still sparse. There is a need to harmonize studies in a global effort to fight the rise of BC incidence in low-and middle-income countries, where the nutritional transition is occurring rapidly. The stratification of BC by specific tumor characteristics needs to be considered since risk factors may be more particularly associated with the promotion of, or protection from, a defined type of BC.

show abstract

Section: B Vitamins Folatementioning

confidence: 99%

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

Romieu

Amadou

Chajès

2017

RIC

View full text Add to dashboard Cite

show abstract

“…Nutritional influences on gene expression are ubiquitous across taxa, genes and tissue types, and are thought to play a critical role in allowing organisms to adjust their development and physiology in response to environmental fluctuations [1][2][3]. Moreover, dysfunctional nutrition-dependent gene expression is thought to underlie many human diseases such as diabetes, obesity, Crohn's disease and possibly even cancer [4][5][6][7][8]. However, the transcriptome-wide magnitude and nature of nutritional plasticity in gene expression remain largely understudied for non-model systems, many of which exhibit remarkable nutrition-dependent developmental plasticity.…”

Section: Introductionmentioning

confidence: 99%

The nutritionally responsive transcriptome of the polyphenic beetle Onthophagus taurus and the importance of sexual dimorphism and body region

et al. 2014

View full text Add to dashboard Cite

Developmental responses to nutritional variation represent one of the ecologically most important classes of adaptive plasticity. However, knowledge of genome-wide patterns of nutrition-responsive gene expression is limited. Here, we studied genome-wide transcriptional responses to nutritional variation and their dependency on trait and sex in the beetle Onthophagus taurus. We find that averaged across the transcriptome, nutrition contributes less to overall variation in gene expression than do sex or body region, but that for a modest subset of genes nutrition is by far the most important determinant of expression variation. Furthermore, our results reject the hypothesis that a common machinery may underlie nutrition-sensitive development across body regions. Instead, we find that magnitude (measured by number of differentially expressed contigs), composition (measured by functional enrichment) and evolutionary consequences (measured by patterns of sequence variation) are heavily dependent on exactly which body region is considered and the degree of sexual dimorphism observed on a morphological level. More generally, our findings illustrate that studies into the developmental mechanisms and evolutionary consequences of nutrition-biased gene expression must take into account the dynamics and complexities imposed by other sources of variation in gene expression such as sexual dimorphism and trait type.

show abstract

“…The incidence of breast cancers is rising among premenopausal women, presenting more aggressive tumor types and worse response [26]. The World Health Organization (WHO) has identified factors that could explain the differences in breast cancer incidence in different countries, some of them interestingly related to nutrition (e.g.…”

Section: Role Of Environment In Dna Methylationmentioning

confidence: 99%

“…The World Health Organization (WHO) has identified factors that could explain the differences in breast cancer incidence in different countries, some of them interestingly related to nutrition (e.g. obesity, alcohol consumption, birth weight and height) [26]. The biological fundament of these environmental influences relays on two concepts: (1) transcriptional responses to particular nutrients are known to differ from one individual to another, depending on the cellular epigenomic profile, and (2) diverse nutrients can induce the writing, reading and erasing of different epigenetic marks, which consequently generate alternative transcriptomes [27,28].…”

Section: Role Of Environment In Dna Methylationmentioning

confidence: 99%

Aberrant DNA Methylation in Breast Cancer Cells

Campoy¹,

Laurito²,

Urrutia³

et al. 2013

Med Epigenet

View full text Add to dashboard Cite

The epigenome is regulated by a large number of macromolecular machines that are dynamically involved in various processes, including DNA methylation, histone modification and non-coding RNA signals, all of them working together to regulate the proper expression of the genome. Thus, in contrast with the genome, whose sequence is carefully conserved during cell life, the epigenome is highly dynamic. The epigenomic modifications are acquired during normal cell differentiation, replicated during mitosis and passed to daughter cells. A fundamental epigenetic attribute is that this plasticity occurs in response to environmental signals. It is therefore now accepted that the environment influences modifications in the cellular transcriptome through the epigenome. In developmental and evolutionary terms, the regulation of gene expression through epigenomic modifications is an advantageous shortcut and a highly conserved mechanism. However, it implies an increased risk for misregulation, as, for example, aberrant epigenomic modifications associate with the development of different human diseases, i.e. lupus, asthma, neurological diseases and cancer. Although epigenetic alterations in breast cancer have been deeply studied and discussed in the last decades, apparently contradictory results are yet often observed. Consequently, in this review, we will briefly discuss the latest findings of aberrant DNA methylation in breast tumorigenesis. Emphasis will be given to the discussion of the idea that different environments could explain paradoxical biological and pathobiological behaviors in individual patients and thus should be taken into consideration for the design and implementation of diagnosis, prognosis and predictive biomarkers.

show abstract

Redefining the impact of nutrition on breast cancer incidence: is epigenetics involved?

Cited by 46 publications

References 297 publications

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

The Role of Diet, Physical Activity, Body Fatness, and Breastfeeding in Breast Cancer in Young Women: Epidemiological Evidence

The nutritionally responsive transcriptome of the polyphenic beetle Onthophagus taurus and the importance of sexual dimorphism and body region

Aberrant DNA Methylation in Breast Cancer Cells

Contact Info

Product

Resources

About