Redefining Staphylococcus aureus bacteremia: A structured approach guiding diagnostic and therapeutic management

Kouijzer, Ilse J.E.; Fowler, Vance G.; Oever, Jaap ten

doi:10.1016/j.jinf.2022.10.042

Cited by 27 publications

(14 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the risk of IE in patients with bloodstream infections depends on the different bacterial species, strategies should be put in place to identify the subgroup of patients with high clinical risk [37]. For example, given the high incidence of IE (6–32%) among patients with Staphylococcus aureus bacteremia (SAB) [37], standard clinical practice is to perform echocardiography in patients with SAB, as a significant portion of these patients have endocarditis in the absence of clinical signs [50]. Scoring systems have been developed to determine the necessity for TEE.…”

Section: Investigation Of Ei During Bacteremia/fungemia Coursementioning

confidence: 99%

Endocarditis in critically ill patients: a review

Nedel,

Boniatti,

Lisboa

2023

Current Opinion in Critical Care

View full text Add to dashboard Cite

Purpose of review To summarize the advances in literature that support the best current practices regarding infective endocarditis (IE) in critically ill patients. Recent findings IE due to rheumatic diseases has decreased significantly, and in fact, the majority of cases are associated with degenerative valvopathies, prosthetic valves, and cardiovascular implantable electronic devices. The Duke criteria were recently updated, addressing the increasing incidence of new risk factors for IE, such as IE associated with the use of endovascular cardiac implantable electronic devices and transcatheter implant valves. The presence of organ dysfunction, renal replacement therapies, or extracorporeal membrane oxygenation should be considered in the choice of drug and dosage in critically ill patients with suspected or confirmed IE. As highlighted for other severe infections, monitoring of therapeutic antibiotic levels is a promising technique to improve outcomes in critically ill patients with organ dysfunction. Summary The diagnostic investigation of IE must consider the current epidemiological criteria and the diagnostic particularities that these circumstances require. A careful evaluation of these issues is necessary for the prompt clinical or surgical management of this infection.

show abstract

Section: Investigation Of Ei During Bacteremia/fungemia Coursementioning

confidence: 99%

Endocarditis in critically ill patients: a review

Nedel,

Boniatti,

Lisboa

2023

Current Opinion in Critical Care

View full text Add to dashboard Cite

show abstract

“…H&E staining images clearly reflected the intact and orderly skin structures in the PNS@CMCS, BSP-CMCS, and BSP-PNS@CMCS groups, in remarkable contrast to the incomplete epidermis in the Ctrl and CMCS groups (Figure a). The epidermal thickness of the newly generated skin is usually used as one of the criteria for wound healing. , It was found that PNS@CMCS (59.36 ± 20.10 μm), BSP-CMCS (62.40 ± 14.96 μm), and BSP-PNS@CMCS (85.50 ± 23.43 μm) groups had significantly thicker epidermis than the Ctrl (35.10 ± 13.27 μm) and CMCS (41.65 ± 13.11 μm) groups (Figure b). Meanwhile, fewer inflammatory cells and more skin appendages could be observed in the newly generated skin tissue of BSP-PNS@CMCS group as compared to other groups, suggesting that the enhanced functional reconstruction of wound tissues by BSP-PNS@CMCS dressings.…”

mentioning

confidence: 96%

“…18,42 After bacterial invasion, most inflammatory factors were significantly upregulated including macrophage receptors (e.g., CD163, CD91). 17,39 The antibacteria activity of the BSP-PNS@CMCS dressings were demonstrated by the reduced local tissue inflammation revealed in the CD163 immunohistochemical staining images on days 2 and 12 (Figure 5c, d). On day 2, the CD163 positive cells in CMCS (5.78 ± 1.96%), PNS@CMCS (3.89 ± 0.77%), BSP-CMCS (4.55 ± 0.56%), BSP-PNS@CMCS (2.64 ± 2.08%) groups were significantly less than those in control (9.28 ± 4.78%) group, which could be ascribed to the inhibited bacteria growth by the innate bacteriostatic activity of CMCS materials.…”

mentioning

confidence: 98%

“…Cutaneous wounds may be infected when they are in contact with these contaminated sources. By contrast, S. aureus colonizes frequently in other sites such as the skin, throat, axillae, groin and intestine, or persistently in a tiny proportion of human’s nose. − Notably, the hypodermis is the predominant site for S. aureus infections to cause cellulitis. After epidermal damage, the dysbiosis of normal microbial community will increase the risk of overgrowth of harmful pathobionts including the S. aureus infection.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Bioinspired Asymmetric Double-Layer Dressings for Stepwise Treatment of Hemorrhagic Wounds

Yang,

Jia,

Wang

et al. 2024

ACS Materials Lett.

View full text Add to dashboard Cite

Although various dressings have been developed for wound healing, ideal dressings are still lacking to meet the requirements of coordinated hemostasis and angiogenesis for the management of hemorrhagic wounds. Herein, inspired by the gradient structure of natural skin, we propose a novel asymmetric double-layer dressing (BSP-PNS@CMCS) with spatiotemporally controllable functions of hemostasis and angiogenesis for the stepwise treatment of hemorrhagic wounds. The BSP-PNS@CMCS dressings are designed with an inner layer of Bletilla striata polysaccharide (BSP) sponges for initial hemostasis and an outer dense layer of carboxymethyl chitosan (CMCS) hydrogels loaded with panax notoginseng saponines (PNS) for angiogenesis during subsequent tissue reconstruction. Through in vivo experiments, we have demonstrated that the BSP-PNS@CMCS dressings could not only significantly reduce bleeding in rat liver-puncture hemorrhage wounds but also accelerate wound closure by suppressing the inflammatory response, promoting angiogenesis and collagen deposition in infected skin wounds of rats. In vitro and in vivo results indicate that such asymmetric double-layer BSP-PNS@CMCS dressing could be a prospective candidate for the stepwise treatment of hemorrhagic wounds, which also provides an effective strategy for other tissue repair applications.

show abstract

“…We read with interest the article by Kouijzer and colleagues 1 , which proposes a new approach to define the extent of infection in patients with Staphylococcus aureus ( S. aureus ) bacteremia. Zhou et al 2 found a reduction in Haemophilus influenzae infection in children during the COVID-19 pandemic; In addition, Duverger et al 3 reported a reduction in the incidence of carbapenem-producing Enterobacteriaceae after the COVID-19 pandemic.…”

mentioning

confidence: 99%