Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options

Beura, Samir Kumar; Dhapola, Rishika; Panigrahi, Abhishek; Yadav, Pooja; Reddy, Dibbanti Harikrishna; Singh, Sarita

doi:10.1016/j.lfs.2022.120855

Cited by 31 publications

(31 citation statements)

References 126 publications

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“…Acupuncture can reduce oxidative stress and reduce neuroinflammation through multiple signal transduction pathways, Aβ Production, aggregation, and phosphorylation of Tau. Beura et al, 2022;Estévez-Silva et al, 2022;Maina et al, 2022). We believe that abnormal mitochondria in susceptible neurons play a source role by providing diffusible hydrogen peroxide on the membrane to the surrounding cytoplasm, as shown in Figure 3.…”

Section: Acupuncture Ameliorates Neuronal Antioxidant Damage As Well ...mentioning

confidence: 95%

Effect and mechanism of acupuncture on Alzheimer’s disease: A review

Dong

Zhu

et al. 2023

Front. Aging Neurosci.

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With the development trend of an aging society, Alzheimer’s disease (AD) has become an urgent problem in the field of medicine worldwide. Cognitive impairment in AD patients leads to a decline in the ability to perform daily living and abnormalities in behavior and personality, causing abnormal psychiatric symptoms, which seriously affect the daily life of patients. Currently, mainly drug therapy is used for AD patients in the clinic, but a large proportion of patients will experience drug efficacy not working, and even some drugs bring severe sleep disorders. Acupuncture, with its unique concept and treatment method, has been validated through a large number of experiments and proved its reliability of acupuncture in the treatment of AD. Many advances have been made in the study of the neurobiological mechanisms of acupuncture in the treatment of AD, further demonstrating the good efficacy and unique advantages of acupuncture in the treatment of AD. This review first summarizes the pathogenesis of AD and then illustrates the research progress of acupuncture in the treatment of AD, which includes the effect of acupuncture on the changes of biochemical indicators in AD in vivo and the specific mechanism of action to exert the therapeutic effect. Changes in relevant indicators of AD similarly further validate the effectiveness of acupuncture treatment. The clinical and mechanistic studies of acupuncture in the treatment of AD are intensified to fit the need for social development. It is believed that acupuncture will achieve new achievements in the treatment of AD as research progresses.

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Section: Acupuncture Ameliorates Neuronal Antioxidant Damage As Well ...mentioning

confidence: 95%

Effect and mechanism of acupuncture on Alzheimer’s disease: A review

Dong

Zhu

et al. 2023

Front. Aging Neurosci.

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“…135 Surprisingly, several antiplatelet phytochemicals have been reported that specifically augment neuroprotection by promoting neurotransmitter homeostasis and neuronal growth factor availability and attenuate neurotoxicity by inhibiting oxidative stress and cerebral inflammation in NDDs (Figure 3). 11,12 Here in this section, we will discuss only those phytochemicals with significant antiplatelet and antithrombotic potential that have substantial beneficial effects on the management of NDDs (Table 2).…”

Section: Natural Antiplatelet Compounds For Nddsmentioning

confidence: 99%

“…Thus, blood platelets are potential peripheral models for studying pathophysiology and theranostic potential of NDDs. 11,12 Emerging research indicates that platelet hyperactivity is a contributing risk factor for developing cerebrovascular complications in NDD pathology. 13 However, to date, no comprehensive review has proposed the potential beneficial effects of antiplatelet drugs and molecules for the treatment of NDDs.…”

Section: Introductionmentioning

confidence: 99%

Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases

Beura

Dhapola

Panigrahi

et al. 2023

Medicinal Research Reviews

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The blood platelet plays an important role but often remains under‐recognized in several vascular complications and associated diseases. Surprisingly, platelet hyperactivity and hyperaggregability have often been considered the critical risk factors for developing vascular dysfunctions in several neurodegenerative diseases (NDDs) like Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. In addition, platelet structural and functional impairments promote prothrombotic and proinflammatory environment that can aggravate the progression of several NDDs. These findings provide the rationale for using antiplatelet agents not only to prevent morbidity but also to reduce mortality caused by NDDs. Therefore, we thoroughly review the evidence supporting the potential pleiotropic effects of several novel classes of synthetic antiplatelet drugs, that is, cyclooxygenase inhibitors, adenosine diphosphate receptor antagonists, protease‐activated receptor blockers, and glycoprotein IIb/IIIa receptor inhibitors in NDDs. Apart from this, the review also emphasizes the recent developments of selected natural antiplatelet phytochemicals belonging to key classes of plant‐based bioactive compounds, including polyphenols, alkaloids, terpenoids, and flavonoids as potential therapeutic candidates in NDDs. We believe that the broad analysis of contemporary strategies and specific approaches for plausible therapeutic treatment for NDDs presented in this review could be helpful for further successful research in this area.

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“…Recently, studies, modern research, and bioinformatics analysis proved the close relationship between Alzheimer's disease, diabetes mellitus, oxidative damage, aging, and cardiovascular disease 14–16 (Fig. 1).…”

Section: Introductionmentioning

confidence: 95%

“…Finally, molecular docking simulations were performed inside a-amylase and acetylcholinesterase enzymes. Recently, studies, modern research, and bioinformatics analysis proved the close relationship between Alzheimer's disease, diabetes mellitus, oxidative damage, aging, and cardiovascular disease [14][15][16] (Fig. 1).…”

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confidence: 96%