“…Similar to prior studies, 32.5% to 35.0% of opioid-experienced individuals and 2.2% to 2.4% of opioid-naive individuals in our study had long-term opioid use after TKR. 8 , 9 , 23 , 24 , 45 , 46 , 47 , 48 Although the incidence of long-term opioid use among opioid-naive individuals is lower than among those with prior opioid use, these results are concerning given the large number of TKR surgical procedures performed annually in the US and projected increases in this surgery in the future. 5 Our results suggest that pre-TKR and post-TKR PT interventions are associated with lower risk of long-term opioid use regardless of prior opioid use.…”