Redefining obesity, diabetes, and race in type I and type II endometrial cancers

The impact of metabolic syndrome on the clinical profile and tumor characteristics of endometrial carcinoma

“…14 Its incidence is growing worldwide due to increase in life expectancy, obesity prevalence and diabetes, both of which are increasing at alarming rates in the United States. 15 Metabolic syndrome (MS) has become a major public health problem in several countries and represents a common clinical condition in countries with a high incidence of obesity and western dietary patterns. Epidemiologic studies have reported associations of EC risk with individual components of the MS, including obesity, type 2 diabetes, and hypertension.…”

Early stage uterine serous carcinoma: Management updates and genomic advances

“…Conversely, those diagnosed with USC and other Type II cancers, are thinner and older, more likely to be African American, and do not necessarily have exposure to unopposed estrogen. Given the recent obesity epidemic, however, contemporary studies demonstrate that women with Type II cancers may have a similar incidence of obesity as those with Type I cancer [26]. Age, however, remains a variable associated with an increased risk for USC.…”