Redefining macrophage and neutrophil biology in the metastatic cascade

Güç, Esra; Pollard, Jeffrey W.

doi:10.1016/j.immuni.2021.03.022

Cited by 82 publications

(57 citation statements)

References 215 publications

(247 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…N1 exhibit antitumor activity, either directly mediated by antibody-dependent cytotoxicity or indirectly mediated by the production of pro-inflammatory cytokines and T cells activation [ 107 ]. TANs, mostly N2, is considered to promote tumor metastasis [ 108 ]. Applying flow cytometry and immunofluorescence staining in Burkitt’s lymphoma Mice model identified that KWAR23 enhances antitumor activities of neutrophils and macrophages by binding SIRPα expressed on human myeloid cell subsets to block CD47/SIRPα discussed above [ 109 ].…”

Section: Macrophages Are Involved In Mediating Immune Suppressionmentioning

confidence: 99%

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Yu-chang

Chen

et al. 2021

Biomark Res

View full text Add to dashboard Cite

Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences suggest that potential mechanisms of macrophage-mediated tumor immune escape imply interpretation and breakthrough to bottleneck of current tumor immunotherapy. Therefore, it is pivotal to understand the interactions between macrophages and other immune cells and factors for enhancing existing anti-cancer treatments. In this review, we focus on the specific signaling pathways through which TAMs involve in tumor antigen recognition disorders, recruitment and function of immunosuppressive cells, secretion of immunosuppressive cytokines, crosstalk with immune checkpoints and formation of immune privileged sites. Furthermore, we summarize correlative pre-clinical and clinical studies to provide new ideas for immunotherapy. From our perspective, macrophage-targeted therapy is expected to be the next frontier of cancer immunotherapy.

show abstract

Section: Macrophages Are Involved In Mediating Immune Suppressionmentioning

confidence: 99%

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Yu-chang

Chen

et al. 2021

Biomark Res

View full text Add to dashboard Cite

show abstract

“…Although a heterogenous population, TAMs often assume a phenotype associated with wound healing and tissue repair, which impairs tumor immunity and promotes (lymph-) angiogenesis. Furthermore, TAMs express multiple proteases and are able to degrade or remodel the ECM, which facilitates tumor cell migration in the tissue [96]. In breast cancer, TAMs have also been shown to aid the actual step of LVI.…”

Section: Role Of Bystander Cells In Lymphatic Invasionmentioning

confidence: 99%

Mechanisms and Clinical Significance of Tumor Lymphatic Invasion

Fujimoto

2021

Cells

View full text Add to dashboard Cite

Tumor-associated lymphatic vessels play an important role in tumor progression, mediating lymphatic dissemination of malignant cells to tumor-draining lymph nodes and regulating tumor immunity. An early, necessary step in the lymphatic metastasis cascade is the invasion of lymphatic vessels by tumor cell clusters or single tumor cells. In this review, we discuss our current understanding of the underlying cellular and molecular mechanisms, which include tumor-specific as well as normal, developmental and immunological processes “hijacked” by tumor cells to gain access to the lymphatic system. Furthermore, we summarize the prognostic value of lymphatic invasion, discuss its relationship with local recurrence, lymph node and distant metastasis, and highlight potential therapeutic options and challenges.

show abstract

“…Macrophages participate in all steps of metastasis. They can be polarized into either proinflammatory M1-like macrophages or anti-inflammatory M2-like macrophages in response to environmental stimuli ( 7 ). In the primary site, tumor-associated macrophages (TAMs) are involved in angiogenesis, migration and intravasation ( 8 ).…”

Section: Immune Cells Modulating Metastatic Niche Formation In the Bonementioning

confidence: 99%

Immune Modulation of Metastatic Niche Formation in the Bone

Cheng

Wang

2021

Front. Immunol.

View full text Add to dashboard Cite

Bone metastasis is commonly seen in patients with breast cancer, prostate cancer and lung cancer. Tumor-intrinsic factors and the tumor microenvironment cooperate to affect the formation of bone metastatic niche. Within the bone microenvironment, immune cells have been regarded as a major contributor to metastatic progression. In this review, we describe the dynamic roles of immune cells in regulating metastatic homing, seeding, dormancy, and outgrowth in the bone. We also summarize the diverse functions of immune molecules including chemokines, cytokines, and exosomes in remodeling the bone metastatic niche. Furthermore, we discuss the therapeutic and prognostic potential of these cellular and molecular players in bone metastasis.

show abstract

Redefining macrophage and neutrophil biology in the metastatic cascade

Cited by 82 publications

References 215 publications

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Mechanisms and Clinical Significance of Tumor Lymphatic Invasion

Immune Modulation of Metastatic Niche Formation in the Bone

Contact Info

Product

Resources

About