Redefining FLASH RT: the impact of mean dose rate and dose per pulse in the gastrointestinal tract
Kevin Liu,
Trey Waldrop,
Edgardo Aguilar
et al.
Abstract:Background: The understanding of how varying radiation beam parameter settings affect the induction and magnitude of the FLASH effect remains limited. Purpose: We sought to evaluate how the magnitude of radiation-induced gastrointestinal (GI) toxicity (RIGIT) depends on the interplay between mean dose rate (MDR) and dose per pulse (DPP). Methods: C57BL/6J mice were subjected to total abdominal irradiation (11-14 Gy single fraction) under conventional irradiation (low DPP and low MDR, CONV) and various combinat… Show more
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