Redefining Diagnostic Symptoms of Depression Using Rasch Analysis: Testing an Item Bank Suitable for DSM-V and Computer Adaptive Testing

Mitchell, Alex J.; Smith, Adam B.; Al‐Salihy, Zerak; Rahim, Twana Abdulrahman; Mahmud, Mahmud Q.; Muhyaldin, Asma S.

doi:10.3109/00048674.2011.596477

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…First, we must consider that in many contexts psychiatric diagnostic is based on a checklist symptom profile, where every symptom is given the same weight to diagnosis (except mood and anhedonia, which are considered necessary symptoms). Understanding the symptoms as a clinical marker of severity may suggest that some of them (e.g., guilt feelings and psychomotor retardation) should have a higher weight on the diagnosis of MDD, in spite of other symptoms that may be not part of the same underlying unidimensional construct [57]. Second, this could be the start point to understand how the severity of melancholia can be related to different brain areas, since different MDD symptoms does not seem to affect only one region of the brain [58].…”

Section: Discussionmentioning

confidence: 99%

The Major Depressive Disorder Hierarchy: Rasch Analysis of 6 items of the Hamilton Depression Scale Covering the Continuum of Depressive Syndrome

et al. 2017

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ObjectivesMelancholic features of depression (MFD) seem to be a unidimensional group of signs and symptoms. However, little importance has been given to the evaluation of what features are related to a more severe disorder. That is, what are the MFD that appear only in the most depressed patients. We aim to demonstrate how each MFD is related to the severity of the major depressive disorder.MethodsWe evaluated both the Hamilton depression rating scale (HDRS-17) and its 6-item melancholic subscale (HAM-D6) in 291 depressed inpatients using Rasch analysis, which computes the severity of each MFD. Overall measures of model fit were mean (±SD) of items and persons residual = 0 (±1); low χ2 value; p>0.01.ResultsFor the HDRS-17 model fit, mean (±SD) of item residuals = 0.35 (±1.4); mean (±SD) of person residuals = -0.15 (±1.09); χ2 = 309.74; p<0.00001. For the HAM-D6 model fit, mean (±SD) of item residuals = 0.5 (±0.86); mean (±SD) of person residuals = 0.15 (±0.91); χ2 = 56.13; p = 0.196. MFD ordered by crescent severity were depressed mood, work and activities, somatic symptoms, psychic anxiety, guilt feelings, and psychomotor retardation.ConclusionsDepressed mood is less severe, while guilt feelings and psychomotor retardation are more severe MFD in a psychiatric hospitalization. Understanding depression as a continuum of symptoms can improve the understanding of the disorder and may improve its perspective of treatment.

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Section: Discussionmentioning

confidence: 99%

The Major Depressive Disorder Hierarchy: Rasch Analysis of 6 items of the Hamilton Depression Scale Covering the Continuum of Depressive Syndrome

et al. 2017

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“…4 According to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, the criteria to diagnose MDD is five of these symptoms for 2 weeks. 5 The investigations into the neurobiology of MDD have focused on different neurotransmitter systems. Since reserpine, a known antihypertension medication that depletes monoamines in the nerve system, 6 can cause depressive symptoms, a monoamine hypothesis proposed that depression patients probably have low levels of monoamine neurotransmitters, epinephrine and serotonin.…”

Section: Introductionmentioning

confidence: 99%

mGluR5 Facilitates Long-Term Synaptic Depression in a Stress-Induced Depressive Mouse Model

et al. 2019

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Background Glutamatergic system has been known to play a role in the pathogenesis of major depression disorder by inducing N-methyl-d-aspartate receptor-dependent long-term depression (LTD) or metabotropic glutamate receptors (mGluR)-dependent LTD. Here, we characterized the LTD in a chronic social defeat stress (CSDS)-induced depressive mouse model. Methods CSDS was used to induce the depressive-like behaviors in C57BL/6 male mice, which were assessed using sucrose preference test and social interaction test. The synaptic strength including LTD and long-term potentiation (LTP) induced by paired-pulse low frequency stimulation (PP-LFS) was measured using whole-cell recording technique. Results CSDS induced depressive-like behaviors and facilitated PP-LFS-induced LTD in hippocampal CA3-CA1 pathway in the susceptible mice. Interestingly, mGluR5 but not N-methyl-d-aspartate receptor mediated the PP-LFS-induced LTD. In addition, mGluR5 agonist dihydroxyphenylglycine promoted PP-LFS-induced LTD specifically in susceptible mice, which was diminished by activating the BDNF/TrkB signaling pathway. Conclusions Our results suggest that mGluR5-dependent LTD might be responsible for the development of depressive-like behaviors in CSDS-induced depression mice model.

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“…In the current international climate, how pleasing it is to see an attractive piece of psychometric research come out of Iraqi Kurdistan, achieved by psychiatrists there in collaboration with UK colleagues. Mitchell et al [7] used the Rasch model to construct a parsimonious tool for detecting depressive disorder. The Rasch model is the simplest model in Item Response Theory, having only one parameter, the threshold.…”

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confidence: 99%

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Henderson

2011

Aust N Z J Psychiatry

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Redefining Diagnostic Symptoms of Depression Using Rasch Analysis: Testing an Item Bank Suitable for DSM-V and Computer Adaptive Testing

Abstract: An item bank of 17 items may be useful in computer adaptive testing and nine or even four items may be used to develop a simplified screening tool for DSM-V major depressive disorder (MDD). Further examination of this item bank should be conducted in different cultural settings.

Cited by 8 publications

References 29 publications

The Major Depressive Disorder Hierarchy: Rasch Analysis of 6 items of the Hamilton Depression Scale Covering the Continuum of Depressive Syndrome

The Major Depressive Disorder Hierarchy: Rasch Analysis of 6 items of the Hamilton Depression Scale Covering the Continuum of Depressive Syndrome

mGluR5 Facilitates Long-Term Synaptic Depression in a Stress-Induced Depressive Mouse Model

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