Redefined Nomenclature for Members of the Carcinoembryonic Antigen Family

Beauchemin, Nicole; Dráber, Petr; Dveksler, Gabriela S.; Gold, Phil; Gray-Owen, Scott D.; Fritz, Günter; Hammarström, Sten; Holmes, Kathryn V.; Karlsson, Anna; Kuroki, Masahide; Lin, S. H.; Lucka, Lothar; Najjar, Sonia M.; Neumaier, Michael; Öbrink, Björn; Shively, J. E.; Skubitz, Keith M.; Stanners, Clifford P.; Thomas, Peedikayil E.

doi:10.1006/excr.1999.4610

Cited by 334 publications

(65 citation statements)

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“…Since the discovery of carcinoembryonic antigen (CEA) some 50 years ago [11], and the subsequent appreciation of a family of CEA-related cell adhesion molecules [12] (Figure 1), numerous physiological and pathological processes have been associated with these mammalian membrane glycoproteins. Historically, cancer is one of the disease states linked to aberrant CEACAM function and the role of epithelial CEACAMs in tumour progression and metastasis has been summarized in an excellent review recently [13].…”

Section: Physiological Roles Of Epithelial Ceacamsmentioning

confidence: 99%

Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria

2014

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Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) comprise a group of immunoglobulin-related vertebrate glycoproteins. Several family members, including CEACAM1, CEA, and CEACAM6, are found on epithelial tissues throughout the human body. As they modulate diverse cellular functions, their signaling capacity is in the focus of current research. In this review we will summarize the knowledge about common signaling processes initiated by epithelial CEACAMs and suggest a model of signal transduction by CEACAM family members lacking significant cytoplasmic domains. As pathogenic and non-pathogenic bacteria exploit these receptors during mucosal colonization, we try to highlight the connection between CEACAMs, microbes, and cellular responses. Special emphasis in this context is placed on the functional interplay between CEACAMs and integrins that influences matrix adhesion of epithelial cells. The cooperation between these two receptor families provides an intriguing example of the fine tuning of cellular responses and their manipulation by specialized microorganisms.

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Section: Physiological Roles Of Epithelial Ceacamsmentioning

confidence: 99%

Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria

2014

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“…Previous studies have reported that expression of CEACAM1 in tumor cells induces production of an inhibitory factor that affects tumor angiogenesis [25] and that epithelial downregulation of CEACAM1 induces angiogenesis via increased expression of vascular endothelial growth factors C and D [26]. CEACAM1, also known as biliary glycoprotein, CD66a, is a member of the CEA subfamily and the immunoglobulin superfamily [27, 28]. Currently, 11 alternative splicing forms of the CEACAM1 gene have been identified [29, 30].…”

Section: Discussionmentioning

confidence: 99%

Downregulation of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Oral Squamous Cell Carcinoma: Correlation with Tumor Progression and Poor Prognosis

et al. 2009

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Objective: To identify genes associated with therapeutic targets of oral squamous cell carcinoma (OSCC), we compared gene expression profiles in OSCC-derived cell lines with human normal oral keratinocytes. Methods: We analyzed the gene expression profiles of OSCCs using Affymetrix GeneChip analysis. The identified genes were analyzed by an Ingenuity Pathway Analysis tool to identify networks of interacting genes. A candidate gene was further evaluated for the expression status of the mRNA and protein in OSCC-derived cell lines and primary OSCCs. Results: The microarray data identified 188 genes downregulated in OSCC-derived cell lines, and the genetic pathways associated with expression changes were generated. Among the genes mapped to the network with the highest significance, carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) was analyzed further. CEACAM1 mRNA and protein were frequently downregulated in OSCC-derived cell lines compared with human normal oral keratinocytes. Immunohistochemical analysis showed that primary OSCCs were significantly decreased in CEACAM1. Moreover, CEACAM1 expression was correlated with the TNM staging. We also found that CEACAM1-negative expression was significant both for disease-free (p = 0.036) and overall survival (p = 0.032). Conclusion: Repression of CEACAM1 could contribute to cancer progression and may indicate a poor prognosis for patients with OSCC.

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“…CEACAMs are known to be highly glycosylated proteins that belong to members of the immunoglobulin (Ig) supergene family and are composed of an N domain (aside from CEACAM16) [1]. Each N domain is subsequently followed by zero or as many as six constant C2-like Ig domains, referred to as A or B [2]. The CEACAM family consists of membrane-linked glycoproteins anchored to the cell surface either by glycophosphatidyl-inositol (GPI) anchor or a transmembrane domain, as well as secretory glycoproteins [3].…”

Section: Introductionmentioning

confidence: 99%

Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies

Johnson

Mahadevan²

2015

CCAND

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Background: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a member of the CEA family of cell adhesion proteins that belong to the immunoglobulin superfamily. CEACAM6 is normally expressed on the surface of myeloid (CD66c) and epithelial surfaces. Stiochiomertic expression of members of the CEA family (CEACAM1, 5, 6, 7) on epithelia maintains normal tissue architecture through homo-and hetero-philic interactions. Dysregulated over-expression of CEACAM6 is oncogenic, is associated with anoikis resistance and an invasive phenotype mediated by excessive TGFβ, AKT, FAK and SRC signaling in human malignancies. Methods: Extensive literature review through PubMed was conducted to identify relevant preclinical and clinical research publications regarding CEACAM6 over the last decade and was summarized in this manuscript. Results: CEACAM5 and 6 are over-expressed in nearly 70% of epithelial malignancies including colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDA), hepatobiliary, gastric, breast, non-small cell lung and head/neck cancers. Importantly, CEACAM6 is a poor prognostic marker in CRC, while its expression correlates with tumor stage, metastasis and post-operative survival in PDA. CEACAM6 appears to be an immune checkpoint suppressor in hematologic malignancies including acute lymphoblastic leukemia and multiple myeloma. Several therapeutic monoclonal antibodies or antibody fragments targeting CEACAM6 have been designed and developed as a targeted therapy for human malignancies. A Llama antibody targeting CEACAM6 is being evaluated in early phase clinical trials. Conclusion: This review focuses on the role of CEACAM6 in the pathogenesis and signaling of the malignant phenotype in solid and hematologic malignancies and highlights its potential as a therapeutic target for anti-cancer therapy.

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Redefined Nomenclature for Members of the Carcinoembryonic Antigen Family

Cited by 334 publications

References 0 publications

Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria

Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria

Downregulation of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Oral Squamous Cell Carcinoma: Correlation with Tumor Progression and Poor Prognosis

Emerging Role and Targeting of Carcinoembryonic Antigen-related Cell Adhesion Molecule 6 (CEACAM6) in Human Malignancies

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