Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase

Sarr, Mamadou; Chataigneau, Marta; Martins, Sandrine Carvalhosa; Schott, Christa; Bedoui, Jasser El; Oak, Min–Ho; Müller, Bernard; Chataigneau, Thierry; Schini‐Kerth, Valérie B.

doi:10.1016/j.cardiores.2006.05.022

Cited by 161 publications

(122 citation statements)

References 44 publications

(51 reference statements)

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“…The NO-mediated component of relaxation was unaltered in mesenteric arteries from angiotensin II-treated rats. In contrast, in large elastic arteries such as aorta in which NO is the main endothelium-derived relaxing factor, chronic administration of angiotensin II induced a significant inhibition of NO-mediated relaxation (Sarr et al, 2006). The decrease has been attributable, in part, to an increased vascular superoxide anion production, which inactivates NO.…”

Section: Discussionmentioning

confidence: 90%

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Angiotensin II-Induced Hypertension Is Associated with a Selective Inhibition of Endothelium-Derived Hyperpolarizing Factor-Mediated Responses in the Rat Mesenteric Artery

Dal-Ros

Bronner²,

Schott³

et al. 2008

J Pharmacol Exp Ther

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Hypertension has been shown to be associated with impaired endothelium-derived hyperpolarizing factor (EDHF)-mediated arterial relaxation and hyperpolarization. Treatments of hypertensive rats with inhibitors of the renin-angiotensin system have been shown to restore both EDHF-mediated responses and the expression of connexins involved in the intercellular transfer of the hyperpolarization in mesenteric arteries. The present study was designed to determine whether chronic treatment of rats with angiotensin II impairs EDHF-mediated responses and the expression of connexins in the mesenteric arterial wall. Male Wistar rats were treated with angiotensin II (0.4 mg/kg/day) for 21 days using osmotic minipumps. Arterial pressure was measured by tail-cuff plethysmography. Contractile responses and membrane potential were measured in isolated mesenteric arteries. The expression of the three connexins (Cxs), Cx37, Cx40, and Cx43, was quantified in segments of mesenteric arteries by immunohistochemistry and quantitative real-time reverse transcriptase-polymerase chain reaction. Angiotensin II administration increased the mean systolic blood pressure. EDHF-mediated relaxation and hyperpolarization to acetylcholine and red wine polyphenols were significantly impaired in mesenteric arteries from angiotensin II-treated rats in comparison with control animals, whereas nitric oxide-mediated relaxation was unaltered. The expression of connexins Cx37, Cx40, and Cx43 was significantly decreased in the mesenteric artery from angiotensin II-treated rats. These findings indicate that angiotensin II-induced hypertension is associated with a selective impairment of EDHF-mediated relaxation and hyperpolarization in the rat mesenteric artery. The inhibition of EDHF-mediated responses is due, at least in part, to a decreased expression of connexins Cx37, Cx40, and Cx43 in the arterial wall.

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Section: Discussionmentioning

confidence: 90%

“…A 1-cm-long incision was made in the midscapular region, and an osmotic minipump (Alzet, model 2004) was implanted. Angiotensin II, contained in the osmotic minipumps, was dissolved in 0.15 mM NaCl containing 0.01 N acetic acid as described previously (Sarr et al, 2006). The infusion rate was 0.4 mg/kg/day.…”

Section: Methodsmentioning

confidence: 99%

Angiotensin II-Induced Hypertension Is Associated with a Selective Inhibition of Endothelium-Derived Hyperpolarizing Factor-Mediated Responses in the Rat Mesenteric Artery

Dal-Ros

Bronner²,

Schott³

et al. 2008

J Pharmacol Exp Ther

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“…Although an inhibition of Ang II-induced hypertension by crude extracts of red wine polyphenol was reported in rat, 26 the effect of resveratrol on Ang II-induced hypertension remains to be determined. We clearly showed that resveratrol inhibited Ang II-induced hypertension.…”

Section: Discussionmentioning

confidence: 97%

Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis

et al. 2009

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Recent studies have shown that resveratrol (3,5,4¢-trihydroxystilbene), a polyphenolic compound found in grapes and red wine, has various beneficial effects on cardiovascular diseases and prolongs the life span of mice fed a high-fat diet. We hypothesized that resveratrol may attenuate vascular inflammatory response induced by angiotensin (Ang) II. We examined the effect of resveratrol on Ang II-induced interleukin (IL)-6 expression in vascular smooth muscle cells (VSMCs). Resveratrol significantly attenuated Ang II-induced IL-6 mRNA expression and IL-6 protein in the supernatant of VSMC in a dose-dependent manner. Resveratrol suppressed the IL-6 gene promoter activity. Resveratrol inhibited the Ang II-induced cAMP-response element-binding protein and nuclear factor-kappa B activity, which are critical for Ang II-induced IL-6 gene activation. An increase in the serum concentration of IL-6 induced by Ang II infusion was attenuated by an oral administration of resveratrol. Resveratrol also inhibited Ang II-induced hypertension and perivascular fibrosis of the heart. Although hydralazine reduced blood pressure level equal to resveratrol, it did not reduce the Ang II-induced IL-6 production and perivascular fibrosis. These data suggest that the inhibition of Ang II-induced vascular inflammation and high blood pressure by resveratrol may contribute, at least in part, to the anti-atherogenic effects of resveratrol.

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“…Indeed, it is now accepted that polyphenols could prevent many diseases such as cancers (Yang et al, 2009;Korkina et al, 2009;Khan et al, 2009;Bracke et al, 2008;Franklin and McCubrey, 2007), cardiovascular (Madeira et al, 2009;Jones et al, 2011;Kumar et al, 2008;Agouni et al, 2009;Walter et al, 2008;SchiniKerth et al, 2011;Sall Diallo et al, 2008;Sarr et al, 2006 ; and degenerative diseases (Mollnau et al, 2006;Chen et al, 2007;Berrino, 2002;Meydani, 2002;Meydani, 2001). Encouraging the consumption of fruits and vegetables is now a major public health recommendation.…”

Section: Discussionmentioning

confidence: 99%

In vitro preventive effects of nitrate tolerance by a polyphenol-enriched extract of Hibiscus sabdariffa

Sarr

Sar²,

Diao³

et al. 2013

J. Clin. Med. Res.

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Treatment failure or tolerance, which rapidly leads to a reduced hemodynamic effects and therapeutic efficacy is the major limitation of long-term use of nitrates, including nitroglycerin (NTG) in the treatment of coronary artery disease. These effects are most often associated with oxidative stress. Thus, in this work, we were interested in the prevention of nitrate tolerance by the antioxidant compounds from Hibiscus sabdariffa L. crude extract, a plant from the Senegalese Pharmacopoeia, rich in polyphenols. Thoracic aorta segments without endothelium were taken from rats and incubated in isolated organ chambers. The vessels were then pre-exposed with the H. sabdariffa polyphenolic extract (HSE, 5.10 -2 g/l) or antioxidants such as N-acetyl cysteine (NAC, 10 -3 M) or vitamin C (VIT C, 10 -2 M), taken as reference. After a 30 min treatment, aortic segments were exposed to NTG (50 μM, 1 h) to induce tolerance state before being contracted to adrenaline (10 -8 to 10 -5 M), and then relaxed with NTG (10 -9 to 10 -5 M). Polyphenols from H. sabdariffa potentiated the relaxant response to NTG, whatever the state of vascular tolerance; the HSE partially corrected the in vitro nitrate tolerance. This work suggests interesting therapeutic perspectives by improving the response to treatment with nitrates in coronary patients.

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Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase

Abstract: Intake of red wine polyphenols prevents Ang II-induced hypertension and endothelial dysfunction. Prevention of vascular NADPH oxidase induction and preservation of arterial nitric oxide availability during Ang II administration likely contribute to this effect.

Cited by 161 publications

References 44 publications

Angiotensin II-Induced Hypertension Is Associated with a Selective Inhibition of Endothelium-Derived Hyperpolarizing Factor-Mediated Responses in the Rat Mesenteric Artery

Angiotensin II-Induced Hypertension Is Associated with a Selective Inhibition of Endothelium-Derived Hyperpolarizing Factor-Mediated Responses in the Rat Mesenteric Artery

Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis

In vitro preventive effects of nitrate tolerance by a polyphenol-enriched extract of Hibiscus sabdariffa

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