Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism

Ndiaye, Mamadou; Chataigneau, Thierry; Andriantsitohaina, Ramaroson; Stoclet, Jean‐Claude; Schini‐Kerth, Valérie B.

doi:10.1016/j.bbrc.2003.09.028

Cited by 98 publications

(83 citation statements)

References 27 publications

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“…For a free Ca 2ϩ concentration of approximately 444 nM (estimated by using the computer program Maxchelator, Stanford University, Stanford, CA), the pipette solution contained 7 mM instead of 2 mM CaCl 2 , and 4 mM instead of 5 mM MgCl 2 , as described previously (Seto et al, 2007). The range of free intracellular Ca 2ϩ concentration chosen in this study was similar to the previously measured global levels observed in agonist-stimulated single porcine coronary arterial myocytes (Ndiaye et al, 2003). To allow for an equilibration of the pipette solution with the cell interior, all recordings were started 5 min after the establishment of the whole-cell configuration.…”

Section: Methodsmentioning

confidence: 87%

Endothelium-Derived Nitric Oxide Inhibits the Relaxation of the Porcine Coronary Artery to Natriuretic Peptides by Desensitizing Big Conductance Calcium-Activated Potassium Channels of Vascular Smooth Muscle

Liang

Au²,

Leung³

et al. 2010

J Pharmacol Exp Ther

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The present experiments investigated whether endothelium-derived mediators modulate the effect of natriuretic peptides in porcine coronary arteries. Rings with and without endothelium were suspended in organ chambers for isometric tension recording. Concentrationrelaxation curves to C-type natriuretic peptide (CNP) and atrial natriuretic peptide (ANP) were obtained during contractions to endothelin-1. Removal of the endothelium potentiated relaxations to both CNP and ANP. N thelium. CNP-induced relaxations were reduced by 8-bromoguanosine 3Ј,5Ј-cGMP (8-bromo-cGMP) to the same extent in rings with and without endothelium. There was no significant difference between the increased cGMP content caused by CNP in porcine coronary arteries with or without endothelium. In patch-clamp studies in porcine coronary arterial smooth muscle cells, the natriuretic peptide-mediated enhancement of the IBTX-sensitive big conductance calcium-activated potassium channel (BK Ca ) amplitude was reversed by SNP and 8-bromo-cGMP. These findings demonstrate that, in the porcine coronary artery, the opening of BK Ca and ATP-dependent potassium channels of the vascular smooth muscle contributes to CNP-mediated relaxations. Endothelium-derived and exogenous NO inhibit the direct relaxing effect of natriuretic peptides by desensitizing the response of the BK Ca s of the vascular smooth muscle to the generation of cGMP.

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Section: Methodsmentioning

confidence: 87%

Endothelium-Derived Nitric Oxide Inhibits the Relaxation of the Porcine Coronary Artery to Natriuretic Peptides by Desensitizing Big Conductance Calcium-Activated Potassium Channels of Vascular Smooth Muscle

Liang

Au²,

Leung³

et al. 2010

J Pharmacol Exp Ther

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“…Resveratrol induces the production of endothelium-derived hyperpolarizing factor in endothelial cells, which is an NO-independent vasodilator for vascular smooth muscle cells. 23) Leblais et al 24) reported that resveratrol might directly induce vascular smooth muscle cell relaxation.…”

Section: )mentioning

confidence: 99%

Differential Effect of Resveratrol on Nitric Oxide Production in Endothelial F-2 Cells

Takahashi

Uchiyama

Toda

2009

Biological & Pharmaceutical Bulletin

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“…Studies have reported the involvement of polyphenols in endothelium-dependent relaxant effects mediated by the liberation of · NO and EDHF (Andriambeloson et al, 1997;De Moura et al, 2002;Ndiaye et al, 2003;De Moura et al, 2004). Senejoux et al (2012) demonstrated the possibility that polyphenolic compounds found in the extract of Nitraria sibirica Pall fruit are involved in its hypotensive properties and endothelium-dependent relaxation effects; these mainly involve · NO liberation, EDHF, and stimulation of the muscarinic receptors.…”

Section: Resultsmentioning

confidence: 99%

Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill) K. Schum

Silva

Lima

Caliman

et al. 2014

Braz. J. Pharm. Sci.

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The aims of this study were to evaluate the chemical profile, vascular reactivity, and acute hypotensive effect (AHE) of the ethanolic extract of leaves of Alpinia purpurata (Vieill) K. Schum (EEAP). Its chemical profile was evaluated using HPLC-UV, ICP-OES, and colorimetric quantification of total flavonoids and polyphenols. The vascular reactivity of the extract was determined using the mesenteric bed isolated from WKY. AHE dose-response curves were obtained for both EEAP and inorganic material isolated from AP (IAP) in WKY and SHR animals. Cytotoxic and mutagenic safety levels were determined by the micronucleus test. Rutin-like flavonoids were quantified in the EEAP (1.8 ± 0.03%), and the total flavonoid and polyphenol ratios were 4.1 ± 1.8% and 5.1 ± 0.3%, respectively. We observed that the vasodilation action of EEAP was partially mediated by nitric oxide ( ). The EEAP and IAP showed an AHE in WKY and SHR animals. EEAP did not have cytotoxic effects or cause chromosomic alterations. The AHE shown by EEAP could result from its endothelium-dependent vascular action. Rutin-like flavonoids, among other polyphenols, could contribute to these biological activities, and the calcium present in EEAP could act in a synergistic way.Uniterms: Alpinia. Alpinia purpurata/phytochemistry. Alpinia purpurata/ethanolic extract/vascular reactivity. Alpinia purpurata/ethanolic extract/acute hypotensive effect. Flavonoids/quantification. Polyphenols/quantification.Os objetivos deste estudo foram avaliar o perfil químico de folhas de Alpinia purpurata K. Schum (AP), assim como a reatividade vascular e o efeito hipotensor agudo (EHA) do extrato etanólico de folhas de AP (EEAP). Avliou-se o perfil químico utilizando-se HPLC-UV, ICP-OES e quantificação colorimétrica de flavonoides e polifenóis totais. A reatividade vascular foi determinada utilizando leito mesentérico isolado de ratos WKY. Curvas dose-resposta do EEAP e do material inorgânico da AP (IAP) foram realizadas em animais SHR e WKY. Determinaram-se a segurança citotóxica e mutagênica pelo teste de micronúcleos. Flavonoides tipo rutina foram quantificados no EEAP (1,8±0,03%) e flavonoide total e polifenóis foram de 4,1±1,8% e 5,1±0,3%, respectivamente. Observou-se ação vasodilatadora do EEAP, mediada parcialmente pelo óxido nítrico (

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Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism

Cited by 98 publications

References 27 publications

Endothelium-Derived Nitric Oxide Inhibits the Relaxation of the Porcine Coronary Artery to Natriuretic Peptides by Desensitizing Big Conductance Calcium-Activated Potassium Channels of Vascular Smooth Muscle

Endothelium-Derived Nitric Oxide Inhibits the Relaxation of the Porcine Coronary Artery to Natriuretic Peptides by Desensitizing Big Conductance Calcium-Activated Potassium Channels of Vascular Smooth Muscle

Differential Effect of Resveratrol on Nitric Oxide Production in Endothelial F-2 Cells

Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill) K. Schum

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