Red raspberry supplementation mitigates alcohol-induced liver injury associated with gut microbiota alteration and intestinal barrier dysfunction in mice

Abstract

Alcoholic liver disease (ALD) is still a global health concern. Long-term alcohol intake alters the gut microbiota diversity and metabolic activity, and causes intestinal barrier dysfunction, leading to the development...

Exploring the potential mechanism of Rubus corchorifolius L. fruit polyphenol-rich extract in mitigating non-alcoholic fatty liver disease by integration of metabolomics and transcriptomics profiling

“…More and more evidence has suggested that R. corchorifolius fruits have various biological functions, especially in combating chronic metabolic diseases like obesity, oxidative damage, and diabetes. 8 Polyphenols from the pulp and whole fruit of R. corchorifolius demonstrated anti-obesity effects in HFD-fed mice by inhibiting the activation of the NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome. 9 In addition, R. corchorifolius intervention significant lowered oxidative stress, alleviated cell damage, and controlled blood sugar levels in db/db mice.…”