Red onion extract (Allium cepa L.) supplementation improves redox balance in oxidatively stressed rats

Onion extract (Allium cepaL.), quercetin and catechin up-regulate paraoxonase 1 activity with concomitant protection against low-density lipoprotein oxidation in male Wistar rats subjected to oxidative stress

“…Previous studies have shown that licorice‐derived glabridin can preserve paraoxonase activity during lipoprotein oxidation, and pomegranate juice consumption also increases PON1 arylesterase activity, in association with a reduction in LDL susceptibility to copper ion‐induced oxidation . These results provide evidence of the positive effect of onion extract on PON1 activity and prevention of LDL oxidation during periods of oxidative insult, with improvement in the antioxidant capability of rats, suggesting its value as a dietary antioxidant food . Moreover, quercetin has been previously shown to exert protective effects on ageing of specific tissues in mouse and other cellular models .…”

“…We have shown in a recent study that supplementation of onion as well as flavonoids improves antioxidant potential in HgCl 2 ‐treated rats . Oral administration of flavonoids (quercetin) enhanced the antioxidative ability of rat plasma, indicating that conjugated metabolites participate in the antioxidant defence .…”

“…We have shown in a recent study that supplementation of onion as well as flavonoids improves antioxidant potential in HgCl 2 -treated rats. 44 Oral administration of flavonoids (quercetin) enhanced the antioxidative ability of rat plasma, indicating that conjugated metabolites participate in the antioxidant defence. 45 Thus, the combination of potent antioxidants (as indicated by increased radical scavenging activity of plasma and inhibition of lipid peroxidation with reduced plasma MDA levels) and active PON1 could possibly play a major role in reducing ox-LDL.…”

“…39 These results provide evidence of the positive effect of onion extract on PON1 activity and prevention of LDL oxidation during periods of oxidative insult, with improvement in the antioxidant capability of rats, suggesting its value as a dietary antioxidant food. 44,46 Moreover, quercetin has been previously shown to exert protective effects on ageing of specific tissues in mouse and other cellular models. 47 Quercetin and its derivative, namely quercetin caprylate as a proteasome activator with antioxidant properties has been reported to influence cellular lifespan, survival and viability of Human foetal lung fibroblast, cell lines derived from a 16-18 week old human foetus (HFL-1) primary human fibroblasts.…”

Effect of aqueous <i>Allium cepa</i> extract from red onion on aluminum chloride- induced anemia in female rats

“…Enitan et al, reported significant increase in packed cell volume, red blood cell count and hemoglobin concentration (Enitan et al, 2012). Increase red blood cells membrane stability and attenuation of HgCl 2 -induced oxidative stress in rats erythrocytes was also reported (Nwaehujo et al, 2014;Jaiswal et al, 2013). In view of all these findings, there is a dearth of information on the effect of Allium cepa on the aluminum-induced anemia.…”