Red nucleus connectivity as revealed by constrained spherical deconvolution tractography

Milardi, Demetrio; Cacciola, Alberto; Cutroneo, Giuseppina; Marıno, Silvia; Irrera, Mariangela; Cacciola, Giorgio; Santoro, Giuseppe; Ciolli, Pietro; Anastasi, Giuseppe; Calabrò, Rocco Salvatore; Quartarone, Angelo

doi:10.1016/j.neulet.2016.05.009

Cited by 32 publications

(26 citation statements)

References 31 publications

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“…These data extend previous works showing that CSD is a robust technique for the in vivo reconstruction of the intricate and complex brain networks (Lambert et al, 2012; Arrigo et al, 2014; Milardi et al, 2015a,b, 2016a,b; Mormina et al, 2015; Cacciola et al, 2016, 2017). …”

Section: Discussionsupporting

confidence: 88%

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The Olfactory System Revealed: Non-Invasive Mapping by using Constrained Spherical Deconvolution Tractography in Healthy Humans

et al. 2017

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Although the olfactory sense has always been considered with less interest than the visual, auditive or somatic senses, it does plays a major role in our ordinary life, with important implication in dangerous situations or in social and emotional behaviors. Traditional Diffusion Tensor signal model and related tractography have been used in the past years to reconstruct the cranial nerves, including the olfactory nerve (ON). However, no supplementary information with regard to the pathways of the olfactory network have been provided. Here, by using the more advanced Constrained Spherical Deconvolution (CSD) diffusion model, we show for the first time in vivo and non-invasively that, in healthy humans, the olfactory system has a widely distributed anatomical network to several cortical regions as well as to many subcortical structures. Although the present study focuses on an healthy sample size, a similar approach could be applied in the near future to gain important insights with regard to the early involvement of olfaction in several neurodegenerative disorders.

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Section: Discussionsupporting

confidence: 88%

“…Using this approach, we have recently shown that a consistent reconstruction of the basal ganglia, red nucleus, claustrum and limbic connectome is feasible (Arrigo et al, 2014; Milardi et al, 2015a,b, 2016a,b; Mormina et al, 2015; Cacciola et al, 2016, 2017). …”

Section: Introductionmentioning

confidence: 99%

The Olfactory System Revealed: Non-Invasive Mapping by using Constrained Spherical Deconvolution Tractography in Healthy Humans

et al. 2017

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“…Especially when making use of probabilistic algorithms for streamline generation, false positives may be reconstructed. In this regard, to make our tractographic findings more consistent, we decided to increase the cutoff for tracking generation and termination, therefore using a conservative approach (Descoteaux et al, 2009 ; Milardi et al, 2016a , b ; Cacciola et al, 2017a ). This was accomplished at the cost of an underestimation issue.…”

Section: Discussionmentioning

confidence: 99%

A Connectomic Analysis of the Human Basal Ganglia Network

et al. 2017

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The current model of basal ganglia circuits has been introduced almost two decades ago and has settled the basis for our understanding of basal ganglia physiology and movement disorders. Although many questions are yet to be answered, several efforts have been recently made to shed new light on basal ganglia function. The traditional concept of “direct” and “indirect” pathways, obtained from axonal tracing studies in non-human primates and post-mortem fiber dissection in the human brain, still retains a remarkable appeal but is somehow obsolete. Therefore, a better comprehension of human structural basal ganglia connectivity in vivo, in humans, is of uttermost importance given the involvement of these deep brain structures in many motor and non-motor functions as well as in the pathophysiology of several movement disorders. By using diffusion magnetic resonance imaging and tractography, we have recently challenged the traditional model of basal ganglia network by showing the possible existence, in the human brain, of cortico-pallidal, cortico-nigral projections, which could be mono- or polysynaptic, and an extensive subcortical network connecting the cerebellum and basal ganglia. Herein, we aimed at reconstructing the basal ganglia connectome providing a quantitative connectivity analysis of the reconstructed pathways. The present findings reinforce the idea of an intricate, not yet unraveled, network involving the cerebral cortex, basal ganglia, and cerebellum. Our findings may pave the way for a more comprehensive and holistic pathophysiological model of basal ganglia circuits.

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“…More recently, we used constrained spherical deconvolution (CSD)‐based tractography, a diffusion MRI‐based technique allowing in vivo reconstruction of connectivity patterns between nervous structures, to study the human analogues of the above‐mentioned direct cortico‐ and dento‐pallidal projections . These connections, likely paralleled by analogue cortico‐ and dento‐nigral pathways, may exert a converging influence of cerebral and neocerebellar cortex on the basal ganglia output nuclei.…”

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confidence: 99%

“…13,14 This scenario has been widely expanded since anatomical studies using retrograde virus tracing demonstrated bidirectional subcortical connections between cerebellum and basal ganglia. 15,16 More recently, we used constrained spherical deconvolution (CSD)-based tractography, a diffusion MRI-based technique allowing in vivo reconstruction of connectivity patterns between nervous structures, [17][18][19][20][21] to study the human analogues of the above-mentioned direct cortico- 22 and dento-pallidal projections. 23 These connections, likely paralleled by analogue cortico- 24 and dento-nigral 23,25 pathways, may exert a converging influence of cerebral and neocerebellar cortex on the basal ganglia output nuclei.…”

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confidence: 99%

Structural connectivity‐based topography of the human globus pallidus: Implications for therapeutic targeting in movement disorders

et al. 2019

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Background Understanding the topographical organization of the cortico‐basal ganglia circuitry is of pivotal importance because of the spreading of techniques such as DBS and, more recently, MR‐guided focused ultrasound for the treatment of movement disorders. A growing body of evidence has described both direct cortico‐ and dento‐pallidal connections, although the topographical organization in vivo of these pathways in the human brain has never been reported. Objective To investigate the topographical organization of cortico‐ and dento‐pallidal pathways by means of diffusion MRI tractography and connectivity based parcellation. Methods High‐quality data from 100 healthy subjects from the Human Connectome Project repository were utilized. Constrained spherical deconvolution–based tractography was used to reconstruct structural cortico‐ and dento‐pallidal connectivity. Connectivity‐based parcellation was performed with a hypothesis‐driven approach at three different levels: functional regions (limbic, associative, sensorimotor, and other), lobes, and gyral subareas. Results External globus pallidus segregated into a ventral associative cluster, a dorsal sensorimotor cluster, and a caudal “other” cluster on the base of its cortical connectivity. Dento‐pallidal connections clustered only in the internal globus pallidus, where also associative and sensorimotor clusters were identified. Lobar parcellation revealed the presence in the external globus pallidus of dissociable clusters for each cortical lobe (frontal, parietal, temporal, and occipital), whereas in internal globus pallidus only frontal and parietal clusters were found out. Conclusion We mapped the topographical organization of both internal and external globus pallidus according to cortical and cerebellar connections. These anatomical data could be useful in DBS, radiosurgery and MR‐guided focused ultrasound targeting for treating motor and nonmotor symptoms in movement disorders. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Red nucleus connectivity as revealed by constrained spherical deconvolution tractography

Cited by 32 publications

References 31 publications

The Olfactory System Revealed: Non-Invasive Mapping by using Constrained Spherical Deconvolution Tractography in Healthy Humans

The Olfactory System Revealed: Non-Invasive Mapping by using Constrained Spherical Deconvolution Tractography in Healthy Humans

A Connectomic Analysis of the Human Basal Ganglia Network

Structural connectivity‐based topography of the human globus pallidus: Implications for therapeutic targeting in movement disorders

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