Red meat intake in chronic kidney disease patients: Two sides of the coin

Mafra, Denise; Borges, Natália Alvarenga; Cardozo, Ludmila F M F; Anjos, Juliana Saraiva dos; Black, Ana Paula; Moraes, Cristiane; Bergman, Peter; Lindholm, Bengt; Stenvinkel, Peter

doi:10.1016/j.nut.2017.08.015

Cited by 61 publications

(30 citation statements)

References 90 publications

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“…However, it is recommended that greater than half of the protein intake should be of a high biologic value such as proteins in eggs, fish, poultry, meat, and dairy products because of the presence of essential amino acids [15]. Nevertheless, higher animal protein consumption, including red meat [16], is associated with rendering the kidneys to excrete a higher acid load as compared to higher dietary plant protein intake [17].…”

Section: Discussionmentioning

confidence: 99%

Patients with chronic kidney disease are not well adhered to dietary recommendations: a cross-sectional study

et al. 2020

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Background: Nutrition and dietary patterns are modifiable factors that can be utilized to prevent or slow the progression of Chronic kidney disease (CKD). Adherence to current dietary recommendations can reduce the incidence, or slow the progression of CKD and reduce mortality. The objectives of this study was to compare the dietary nutrient intake of CKD patients (CKD above stage 3 including hemodialysis) to dietary recommendations and to assess the correlations of those dietary nutrient intakes with each other and with chosen laboratory measurements. Methods: A hospital-based cross-sectional study was conducted among 100 patients with CKD. A consecutive 7 days dietary record supplemented with interviews for data completion was used to assess dietary intake. Recent clinical laboratory measurements were obtained from patients' medical records. The obtained dietary data were analyzed by the Ethiopian food composition database and the nutrisurvey software. Dietary energy and nutrients intake were compared with recommendations for CKD patients. Results: The dietary energy intake (DEI) of almost all patients was below recommended levels. The average Dietary protein intake (DPI) was above the recommended levels (0.95 ± 0.27 g/kg/day) for about 60% of the respondents. Besides, 38% and only two of the respondents had their dietary phosphorus and potassium intakes above recommended levels, respectively. Estimated Glomerular filtration rate (eGFR) was positively correlated with both total and animal protein intakes while blood levels of creatinine and urea were negatively correlated with animal protein intake. Conclusion: Patients with CKD are not well adhered to dietary recommendations and some nutrients showed correlation with chosen clinical laboratory measurements. Besides, DEI and DPI were below and above recommended levels, respectively, for most patients. Besides, more than one-third of the participants had phosphorus intakes above recommendation. These non-optimal dietary nutrient intakes may contribute to fast clinical deterioration and mortality.

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Section: Discussionmentioning

confidence: 99%

Patients with chronic kidney disease are not well adhered to dietary recommendations: a cross-sectional study

et al. 2020

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“…Although the classic view is that renal injury induced by a high-protein diet is caused by changes in glomerular haemodynamics (32) (Figure 2), increasing evidence suggests that CKD risk is associated with protein originating from red meat and not with protein from dairy or vegetable-based sources (33). For example, epidemiological studies conducted in Singapore (34) and the USA (35) (36) have shown that among different protein sources (including red meat, poultry, dairy products, fish eggs and legumes) only red meat (beef, pork and lamb) and processed meat increased the risk of CKD.…”

Section: [H1] High-protein Diets and Dehydrationmentioning

confidence: 99%

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

Stenvinkel

Painer²,

Kuro‐o

et al. 2018

Nat Rev Nephrol

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Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these complications. Domestic and captive wild felids, for example, show susceptibility to chronic kidney disease (CKD), potentially linked to the high protein intake of these animals. By contrast, naked mole rats are a model of longevity and are protected from extreme environmental conditions through mechanisms that provide resistance to oxidative stress. Biomimetic studies suggest that the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) offers protection in extreme environmental conditions and promotes longevity in the animal kingdom. Similarly, during months of fasting, immobilization and anuria, hibernating bears are protected from muscle wasting, azotaemia, thrombotic complications, organ damage and osteoporosis - features that are often associated with CKD. Improved understanding of the susceptibility and protective mechanisms of these animals and others could provide insights into novel strategies to prevent and treat several human diseases, such as CKD and ageing-associated complications. An integrated collaboration between nephrologists and experts from other fields, such as veterinarians, zoologists, biologists, anthropologists and ecologists, could introduce a novel approach for improving human health and help nephrologists to find novel treatment strategies for CKD.

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“…However, it remains unclear if LPD+KA could also affect the microbiota to decrease URS production or it is only the consequence of reduction of protein intake. A recent pilot prospective study has reported that LPD significantly reduces TMAO plasma concentration [ 74 ]. However, no large randomized controlled trials of LPD/LPD + KA has been designed to test the effectiveness of this dietary strategy at reducing URS and are eagerly needed.…”

Section: Role Of Dietary Restrictions On Urs Productionmentioning

confidence: 99%

The Role of Gut Microbiota and Diet on Uremic Retention Solutes Production in the Context of Chronic Kidney Disease

Koppe

Fouque

Soulage

2018

Toxins

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Uremic retention solutes (URS) are associated with cardiovascular complications and poor survival in chronic kidney disease. The better understanding of the origin of a certain number of these toxins enabled the development of new strategies to reduce their production. URS can be classified according to their origins (i.e., host, microbial, or exogenous). The discovery of the fundamental role that the intestinal microbiota plays in the production of many URS has reinstated nutrition at the heart of therapeutics to prevent the accumulation of URS and their deleterious effects. The intestinal microbiota is personalized and is strongly influenced by dietary habits, such as the quantity and the quality of dietary protein and fibers. Herein, this review out lines the role of intestinal microbiota on URS production and the recent discoveries on the effect of diet composition on the microbial balance in the host with a focus on the effect on URS production.

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Red meat intake in chronic kidney disease patients: Two sides of the coin

Cited by 61 publications

References 90 publications

Patients with chronic kidney disease are not well adhered to dietary recommendations: a cross-sectional study

Patients with chronic kidney disease are not well adhered to dietary recommendations: a cross-sectional study

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

The Role of Gut Microbiota and Diet on Uremic Retention Solutes Production in the Context of Chronic Kidney Disease

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