Red meat and type 2 diabetes: do methodological advancements sufficiently increase the certainty of evidence?

Kremer, Daan

doi:10.1016/j.ajcnut.2023.09.022

The American Journal of Clinical Nutrition

2023

DOI: 10.1016/j.ajcnut.2023.09.022

|View full text |Cite

Red meat and type 2 diabetes: do methodological advancements sufficiently increase the certainty of evidence?

Daan Kremer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis

Liu,

Deng,

Liu

et al. 2024

Nutrients

View full text Add to dashboard Cite

Existing research indicates that different types of meat have varying effects on health and aging, but the specific causal relationships remain unclear. This study aimed to explore the causal relationship between different types of meat intake and aging-related phenotypes. This study employed Mendelian randomization (MR) to select genetic variants associated with meat intake from large genomic databases, ensuring the independence and pleiotropy-free nature of these instrumental variables (IVs), and calculated the F-statistic to evaluate the strength of the IVs. The validity of causal estimates was assessed through sensitivity analyses and various MR methods (MR-Egger, weighted median, inverse-variance weighted (IVW), simple mode, and weighted mode), with the MR-Egger regression intercept used to test for pleiotropy bias and Cochran’s Q test employed to evaluate the heterogeneity of the results. The findings reveal a positive causal relationship between meat consumers and DNA methylation PhenoAge acceleration, suggesting that increased meat intake may accelerate the biological aging process. Specifically, lamb intake is found to have a positive causal effect on mitochondrial DNA copy number, while processed meat consumption shows a negative causal effect on telomere length. No significant causal relationships were observed for other types of meat intake. This study highlights the significant impact that processing and cooking methods have on meat’s role in health and aging, enhancing our understanding of how specific types of meat and their preparation affect the aging process, providing a theoretical basis for dietary strategies aimed at delaying aging and enhancing quality of life.

show abstract

Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis

Liu,

Deng,

Liu

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Red meat and type 2 diabetes: do methodological advancements sufficiently increase the certainty of evidence?

Cited by 1 publication

References 14 publications

Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis

Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis

Contact Info

Product

Resources

About