Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats

Abstract

Red Liriope platyphylla (RLP) manufactured by two repeated steps (steaming and drying) stimulates the insulin secretion ability and glucose receptor signaling pathway in an animal model for type I diabetes. This study examined the levels of glucose and lipid metabolism-related factors in a useful animal model for type II diabetes with obesity following RLP treatment for 3 weeks to determine if RLP treatment affects the glucose concentration, insulin secretion and fatty acid oxidation. The following results were obtained: i) RLP contained a large amount of polyphenolic compounds; ii) insulin secretion was induced in RLP-treated OLETF rats, although there were no significant differences in body weight, glucose tolerance test and glucose concentration; iii) the RLP-treated OLETF rats showed a significant increase in adiponectin concentration but the concentration of triglyceride and LDL decreased compared to the vehicle-treated rats; iv) although the abdominal fat mass and adipocyte size did not change with RLP treatment, expression of the adipocyte marker genes and β-oxidation genes in fat tissue was recovered to the level of the LETO rats; v) fatty liver formation was reduced dramatically in the liver of the RLP-treated group compared to the vehicle-treated group; vi) the expression of adipocyte marker genes and the β-oxidation gene in the liver tissue were generally similar to those of the abdominal fat but PPAR-γ showed a reverse pattern in the RLP- and vehicle-treated OLETF rats. These results suggest that RLP may stimulate insulin secretion and a decrease in lipid in serum, and may also suppress fatty liver formation through the regulation of fatty acid oxidation. The data presented here highlight the possibility that RLP can be considered a candidate for the prevention or alleviation of obesity-related diseases.

Phytochemical and pharmacological overview on <i>Liriopes radix</i>

“…AEtLP to ICR mice displayed a significant reduction of the glucose and increased insulin concentrations [37]. Significant alterations on serum adiponectin and lipid concentration [35,36] with GLUT-3, GLUT-1, JNK, and p38 pathway [35] and SOD expressions [37] were also reported. The insulin level was dramatically elevated upon co-treatment with high glucose and AEtLP in INS-1 cells may be tightly correlated with calcium regulation [38,39].…”

“…In addition, it inhibits glycogen synthase kinase-3 (GSK-3) expression and increases IR, IRS-1, PI3K, protein kinase B (Akt), and glucose transport protein (GLUT)-4 expressions in the liver [34]. AEtLP dramatically decreased the abdominal fat mass and slightly decreased the glucose concentration [35], although no significant differences in body weight, glucose tolerance, and glucose concentration [36] in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. AEtLP to ICR mice displayed a significant reduction of the glucose and increased insulin concentrations [37].…”

Effects of Liriopis Tuber on 4-HNE-induced Apoptosis in PC-12 Cells

“…麥門冬(Liriopis Tuber, LT)은 백합과(Liliaceae)에 속한 다년생 초본인 맥문동 Liriope platyphylla WANG et TANG 의 뿌리의 팽대부로 養陰潤肺, 淸心除煩, 益胃生津한다 10) . 맥문동에 대한 실험적 연구로 천식 11) , 항박테리아 12) , 당 뇨 [13][14][15][16] 및 학습 기억 17) 등의 연구가 보고되었다.…”

Effects of Dietary Supplementation of Aqueous Extracts of Liriopeplatyphylla and Akebiaquinata on Breast Meat Qualities of Broiler Chickens

“…Liriopeplatyphylla has been used as a traditional medicine in asthma, bronchial and lung inflammation in Korea, China and Japan. In addition, the extract effectively prevents obesity, diabetes and neurodegenerative disease (Lee et al, 2012).…”