Red–Green–Blue Electrogenerated Chemiluminescence Utilizing a Digital Camera as Detector

Doeven, Egan H.; Barbante, Gregory J.; Kerr, Emily; Hogan, Conor F.; Endler, John A.; Francis, Paul S.

doi:10.1021/ac404135f

Cited by 112 publications

(90 citation statements)

References 41 publications

(55 reference statements)

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“…To date, researchers have made substantial progress in developing portable detectors compatible with miniaturized ECL devices. [63][64][65][66][67] Carvajal et al systematically analyzed three different ECL detection systems, one with a photomultiplier and a photocounting device, the other two were based on photodiodes, one with reprogrammable analog electronics and the other with conventional circuitry. [63] All three detectors were tested using the Ru(bpy) 3 2 + /triethylamine (TEA) ECL system.…”

Section: Other Novel Devicesmentioning

confidence: 99%

“…Doeven et al strategically combined the distinct excitation and emission properties of red (R), green (G), and blue (B) ECL emitters with the inherent color selectivity of a conventional digital camera to create a new approach for multiplexed ECL detection. [66] Using this system, the RGB ECL intensity versus applied-potential curves was isolated to a single emitter at each potential. All three emitters were efficiently resolved over the 3-D space of ECL intensity versus applied potential and emission wavelength.…”

Section: Other Novel Devicesmentioning

confidence: 99%

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Electrochemiluminescence Detection in Paper‐Based and Other Inexpensive Microfluidic Devices

et al. 2017

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There is a need in the field of microfluidics for integration of analytical detection methods onto small fluidic chips. Electrogenerated chemiluminescence (ECL) is an effective method for detecting a wide range of analytes, including small molecules, metal ions and bacteria. This Minireview discusses recent applications of ECL-based detection methods to inexpensive microfluidic devices. We discuss various paper and cloth based devices, including 3D-origami devices and devices utilizing bipolar electrodes. We also discuss novel devices that have replaced traditional instrumentation with inexpensive and portable equipment, such as mobile phones.

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Section: Other Novel Devicesmentioning

confidence: 99%

Section: Other Novel Devicesmentioning

confidence: 99%

Electrochemiluminescence Detection in Paper‐Based and Other Inexpensive Microfluidic Devices

et al. 2017

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“…In addition, tunable ECL emission from three-color ECL system consisting of a deep red emitter [Ru(bpy) 2 (dm-bpy-dc)] 2? , a strong green emitter Ir(ppy) 3, and a blue emitter Ir(ppy) 2 (ptp), was recorded by a conventional digital camera with adjusting the potential [109]. To date, the generation of multiple emission colors with a common co-reactant in many cases has been limited to the proof-of-concept experiment with two or three ECL emitters in organic solvents.…”

Section: (Bps)]mentioning

confidence: 99%

Imaging Analysis Based on Electrogenerated Chemiluminescence

et al. 2017

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Electrochemiluminescence (ECL), also called electrogenerated chemiluminescence, is luminescence that is produced by chemical reactions triggered by electrochemical method. ECL imaging is a novel imaging technique, which can simultaneously provide two kinds of signals of both electrochemistry and optical image. Over the past two decades, ECL imaging has been not only a powerful tool for investigating the fundamental scientific questions such as ECL mechanisms and reaction kinetics, but also a versatile analytical technique for detection of a wide range of analytes including small molecules, DNA, proteins, and cells. In the first part of this review, we briefly describe the reaction mechanisms of ECL generation. Then the review focuses on the research progress on the ECL imaging approach. It is basically introduced from the following five aspects: (i) visualization of electroactive sites on surfaces, (ii) imaging analysis at the single-bead and single-cell levels, (iii) array bioanalysis, (iv) multi-color ECL imaging, and (v) paper chip based on ECL imaging. Finally, some perspectives and future directions in this active research area are presented.

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“…With their storage capacity, smart devices serve clinical practice well, enabling information to be collected and stored to a much greater extent than previously possible. Modern smart devices possess both a light source (LED flash) and a digital camera for detection; therefore they are capable of performing tasks that are normally performed by expensive techniques, such as fluorometers, spectrophotometers, or silicon photodetectors [140].…”

Section: Readout Outcomesmentioning

confidence: 99%

Paper and Fiber-Based Bio-Diagnostic Platforms: Current Challenges and Future Needs

2017

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Abstract:In this perspective article, some of the latest paper and fiber-based bio-analytical platforms are summarized, along with their fabrication strategies, the processing behind the product development, and the embedded systems in which paper or fiber materials were integrated. The article also reviews bio-recognition applications of paper/fiber-based devices, the detected analytes of interest, applied detection techniques, the related evaluation parameters, the type and duration of the assays, as well as the advantages and disadvantages of each technique. Moreover, some of the existing challenges of utilizing paper and/or fiber materials are discussed. These include control over the physical characteristics (porosity, permeability, wettability) and the chemical properties (surface functionality) of paper/fiber materials are discussed. Other aspects of the review focus on shelf life, the multi-functionality of the platforms, readout strategies, and other challenges that have to be addressed in order to obtain reliable detection outcomes.

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Red–Green–Blue Electrogenerated Chemiluminescence Utilizing a Digital Camera as Detector

Cited by 112 publications

References 41 publications

Electrochemiluminescence Detection in Paper‐Based and Other Inexpensive Microfluidic Devices

Electrochemiluminescence Detection in Paper‐Based and Other Inexpensive Microfluidic Devices

Imaging Analysis Based on Electrogenerated Chemiluminescence

Paper and Fiber-Based Bio-Diagnostic Platforms: Current Challenges and Future Needs

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