Red grape skin and seeds polyphenols: Evidence of their protective effects on endothelial progenitor cells and improvement of their intestinal absorption

Felice, Francesca; Zambito, Ylenia; Colo, Giacomo Di; D’Onofrio, Claudio; Fausto, Catia; Balbarini, Alberto; Stefano, Rossella Di

doi:10.1016/j.ejpb.2011.09.002

Cited by 41 publications

(29 citation statements)

References 52 publications

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“…Polyphenols, secondary plant metabolites, are able to contrast this kind of stress [25]. Apples and apple products are a good source of polyphenols, particularly in some ancient cultivars the "high polyphenol content" trait can be present [8].…”

Section: Apple Juice Polyphenolic and Ascorbic Acid Contentsmentioning

confidence: 99%

Apple juices from ancient Italian cultivars: a study on mature endothelial cells model

Felice¹,

Maragò²,

Sebastiani³

et al. 2015

Fruits

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-Introduction. Endothelial cell death due to increased reactive oxygen species (ROS), contributes to the initial endothelial dysfunction, which promotes atherosclerotic lesions. Several fruit products, including apple and apple juice (AJ), are reported to be beneficial for humans' health. However, the protective effect of different kind of apples and particularly ancient varieties remain unknown. This study aimed to investigate the effects of three Italian local ancient variety AJ on human umbilical vascular endothelial cells (HUVECs) model system. Materials and methods. Antioxidant activity and phenolic content were determined in 'Nesta', 'Panaia-red' and 'Cipolla' Italian local ancient variety AJ. 'Golden Delicious' variety AJ was used as control. HUVECs were treated for 24 h with various concentrations in total polyphenols of AJ (5-50-100 mg L −1 ) and then with 2 mM of H 2 O 2 for 1 h. Cytotoxicity and ROS production were evaluated as appropriate. Results and discussion. 'Panaia-red' AJ showed strong antioxidant capacity and a higher content in total polyphenols compared to 'Cipolla', 'Nesta' and 'Golden Delicious' varieties. Moreover, 'Panaia-red' AJ pretreatment significantly improved cell viability and resistance to oxidation (P < 0.05). Conclusion. The results of our study might be useful to revalue ancient Italian apple varieties and to develop new apple-based products with health beneficial properties.

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Section: Apple Juice Polyphenolic and Ascorbic Acid Contentsmentioning

confidence: 99%

Apple juices from ancient Italian cultivars: a study on mature endothelial cells model

Felice¹,

Maragò²,

Sebastiani³

et al. 2015

Fruits

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“…The antioxidant competence of GSE constituents as a whole was correlated with concentration by reacting standards, of known GSE concentrations in phosphate buffer pH 7.4 (PB) 0.13 M (isosmotic), with the Folin-Ciocalteu reagent (Sigma), and measuring the resulting absorbance at 750 nm, as previously described [9,16]. Samples and standards were stabilised for at least 5 h by adding 0.05 mg/ml N-acetylcysteine (NAC).…”

Section: Quantitative Determination Of Whole Antioxidant Competence Omentioning

confidence: 99%

“…Unfortunately the amount of red wine needed to provide a level of phenolic compounds in the organism adequate to produce a significant antioxidant effect is too high to allow one to disregard the harmful consequences of alcohol [8], such as increased incidence of cardiomyopathies, hypertension and ictus. In a recent study it was shown that the antioxidant products extracted from Italian red grape skin and seeds (essentially polyphenols) can exert the same beneficial effects on EPC as red wine, in the absence of alcohol [9]. Aiming at designing an adequate pharmaceutical system for the administration of red grape seed extract (GSE), nanoparticle dispersions were prepared by ionotropic gelation of thiolated quaternary ammoniumechitosan conjugates with hyaluronic acid [10].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles based on quaternary ammonium–chitosan conjugate: A vehicle for oral administration of antioxidants contained in red grapes

Fabiano

Mattii

Braca

et al. 2016

Journal of Drug Delivery Science and Technology

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“…Several researches [46,47] have found an inverse correlation between polyphenols assumption and CVD risk and mortality. In fact such healthy effects may explain the protective action on CVD exerted by food and beverages rich in polyphenols such as wine and tea or fruit juice [48,49] . The beneficial effects of polyphenols are mediated by many biochemical pathways; these compounds indeed improve endothelial function and increase NO release, modulate inflammation and lipid metabolism, protect against atherothrombotic events and platelet aggregation, and increase antioxidant status [33] .…”

Section: Endothelial Health Maintenance: the Nutraceutical Approachmentioning

confidence: 99%

Nutraceuticals and cardiovascular risk: potential role of EPCs modulation

Russo

Lucchesi

Longo

et al. 2015

Stem Cell Transl Investig

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According to WHO cardiovascular diseases (CVDs) are the first cause of death in the world: more people die annually from CVDs than from any other cause. Vascular endothelium plays a pivotal role in the onset and progression of these pathologies and cardiovascular risk factors are frequently associated to the levels of endothelial progenitor cells (EPCs), bone marrow-derived circulating progenitors for the endothelial lineage. Since EPCs not only preserve vascular endothelium homeostasis, but might directly participate to re-endothelization and neovascularization, these cells represent an emerging protagonist in vascular competency and as such a cell model of great interest. An unhealthy diet is one of the main cardiovascular risk factor, while there is a great interest in the potential protective effects of "nutraceuticals", food-derived compounds that exert beneficial effects on human and animal health. The characterization of the endothelial effects of different nutraceuticals may provide fresh insights into their potential role in CVDs prevention. Several studies have already showed the protective effects of natural antioxidants on EPCs levels and functionality; some examples are resveratrol, catechin and folic acid. Fermentation has recently shown interesting roles in cardiovascular prevention since this process gave origin to a new class of foods, rich in bioactive compounds, the fermented foods. Consumption of fermented legumes and cereals, but also fermented beverages (such as beer and wine) was found to protect endothelial function through both lipid-lowering, as well anti-inflammatory and antioxidative mechanisms. Little is known about the effects of fermentation-derived nutraceuticals on EPCs. Given the important role of this cardiovascular biomarker, further analysis in this field can improve opportunities for CVDs prevention and treatment. Vascular endothelium and EPCs: new insightsFor many years vascular endothelium has been considered a mere physical barrier between blood and underlying tissues; recent studies have demonstrated new and interesting roles of endothelium in vascular health [1] .Endothelial cells composing this monolayer have therefore paracrine, endocrine and autocrine functions, by secreting several factors with vasodilatory and antiproliferative effects, such as endothelium-derived hyperpolarization factor (EDHF), nitric oxide (NO) and prostacyclin (PGI 2 ), and others inducing vasoconstrictor response, for instance endothelin-1 (ET-1), angiotensin II and reactive oxygen species (ROS) [2] . These evidences make the vascular endothelium a multifunctional unit that regulates vascular homeostasis by REVIEW

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Red grape skin and seeds polyphenols: Evidence of their protective effects on endothelial progenitor cells and improvement of their intestinal absorption

Cited by 41 publications

References 52 publications

Apple juices from ancient Italian cultivars: a study on mature endothelial cells model

Apple juices from ancient Italian cultivars: a study on mature endothelial cells model

Nanoparticles based on quaternary ammonium–chitosan conjugate: A vehicle for oral administration of antioxidants contained in red grapes

Nutraceuticals and cardiovascular risk: potential role of EPCs modulation

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