Red Ginseng Dietary Fiber Shows Prebiotic Potential by Modulating Gut Microbiota in Dogs

Song, Hyokeun; Lee, Junbum; Yi, Saehah; Kim, Woo-Hyun; Kim, Yuna; Namgoong, Beomkwan; Choe, Ahreum; Cho, Gunhee; Shin, Jangmi; Park, Youngsik; Kim, Min Su; Cho, Seongbeom

doi:10.1128/spectrum.00949-23

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Paeniclostridium is a pathogenic bacterium ( DeCandia et al, 2023 ) that induces inflammation in the intestinal tract and in various tissues in animals ( Nyaoke et al, 2020 ; Gryaznova et al, 2021 ), via its ability to produce cytotoxic endotoxins ( Watts et al, 2019 ; Li et al, 2022 ). Consistent with our results, these studies demonstrated that polysaccharide components contained in American ginseng and red ginseng can effectively regulate the bacterial composition of the intestinal tract of animal animals, significantly increase the abundance of beneficial bacteria and reduce the level of pathogenic bacteria, which is beneficial to the improvement of diarrhea in animals ( Sha et al, 2023 ; Song et al, 2023 ; Min et al, 2024 ). We also detected Fibrobacterota in the intestine, and although its abundance did not differ not significantly among the groups, LEfSe analysis revealed that Fibrobacterota and its subordinate multiple bacteria, from the class to the genus level, were significantly enriched, with the highest contribution in the LGR group.…”

Section: Discussionsupporting

confidence: 89%

Beneficial effects of American ginseng (Panax quinquefolius L.) extract residue as a feed additive on production, health status, and gastrointestinal bacteria in sika deer (Cervus nippon)

Wu,

Zhao,

Zheng

et al. 2024

Front. Microbiol.

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American ginseng residue is an industrial by-product of ginseng saponin extraction, including polysaccharides and amino acids; however, it is often discarded into the natural environment, representing a waste of resources as well as an environmental issue. In this study, we examined the effects of adding American ginseng residue to the basal diet of sika deer. Twelve antler-bearing male sika deer were assigned randomly to groups fed a diet supplemented with 0% (CON), 1% (LGR), and 3% (HGR) American ginseng residue, respectively, (n = 4 per group) for 5 weeks. Supplementation with 3% American ginseng residue significantly increased antler production and feed utilization efficiency in antler-bearing sika deer (p < 0.05). There were no significant differences in serum biochemical indexes among the three groups, but serum immunoglobulin A and glutathione peroxidase levels were significantly increased in the LGR and HGR groups (p < 0.05). Supplementation with American ginseng residue affected rumen fermentation in sika deer, significantly increasing the rumen contents of acetic acid, propionic acid, and total volatile fatty acids, and decreasing rumen fluid pH (p < 0.05), but had no significant effect on microbial protein or ammoniacal nitrogen content. American ginseng residue also affected the rumen bacterial composition, with significant up-regulation of Bacteroidota abundance in the HGR group, significant increases in Fibrobacterota and Fibrobacter abundance in the LGR group, and a significant decrease in Oscillospiraceae_UCG-005. Supplementation with ginseng residue had no significant effect on volatile fatty acids in the feces of sika deer, but did affect the composition of fecal bacteria, with significant decreases in Desulfobacterota and Rikenellaceae_RC9_gut_group in the HGR group, and a significant increase in Ruminococcus in the LGR group (p < 0.05). In addition, the abundance of Paeniclostridium in the feces decreased linearly with increasing concentration of ginseng residue, with a significant difference among the groups (p < 0.05). This study comprehensively evaluated the effects of American ginseng residue as a potential feed additive on the production performance and gastrointestinal bacterial community in antler-bearing sika deer. The results indicated that ginseng residue was a suitable feed additive for improving production performance and health in sika deer.

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Section: Discussionsupporting

confidence: 89%

Beneficial effects of American ginseng (Panax quinquefolius L.) extract residue as a feed additive on production, health status, and gastrointestinal bacteria in sika deer (Cervus nippon)

Wu,

Zhao,

Zheng

et al. 2024

Front. Microbiol.

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“…in comparison to hydrolysed or high-protein diets [ 29 ], for weight loss [ 30 ] or to modulate intestinal postbiotics [ 31 ]) or functional properties of certain types of fibre naturally occurring in raw ingredients (e.g. grains or cereals [ 32 ], miscanthus [ 33 ] or – recently – red ginseng [ 34 ]) or fibre blends [ 31 ], there is no study that compares single DFs from different broad fibre ‘categories’ in the same dogs. This seems particularly surprising for PSY, as this is one of the most commonly recommended DFs for use in intestinal disorders in dogs [ 35 36 ].…”

Section: Discussionmentioning

confidence: 99%

Microbiota of healthy dogs demonstrate a significant decrease in richness and changes in specific bacterial groups in response to supplementation with resistant starch, but not psyllium or methylcellulose, in a randomized cross-over trial

Salavati Schmitz,

Salgado,

Glendinning

2024

Access Microbiology

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Effect of fermented total mixed rations on rumen microbial communities and serum metabolites in lambs

Liu,

Zhang,

Liu

et al. 2024

Grassland Research

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BackgroundDiet regulates rumen microbiota, which in turn affects animal health. The present study evaluated the response of rumen microbiota and the immune system of lambs to a fermented total mixed ration diet.MethodsA total of 30 lambs were assigned into two groups: a group fed an unfermented high‐fiber diet (total mixed ration [TMR]) and a group fed an fermented low‐fiber diet (fermented TMR [FTMR]).ResultsThe results showed that FTMR markedly (p < 0.05) increased average daily gain and dry matter intake compared to TMR. The FTMR diet increased the relative abundance of Veillonellaceae_UCG‐001 and decreased the diversity of undesirable microbiota despite stable overall microbial community diversity. Serum metabolomic analysis combined with enrichment analysis showed that serum metabolites were affected by the FTMR and metabolic pathways, and the FTMR diet significantly (p < 0.05) influenced amino acid metabolism of lambs. There was a decrease in inflammatory factors in the FTMR treatment, indicating that inflammatory factors followed the same trajectory as changes in microbial community structure and function.ConclusionsOverall, the FTMR diet reduced undesirable microbiota diversity, thereby regulating host amino acid metabolism and improving immune status.

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Red Ginseng Dietary Fiber Shows Prebiotic Potential by Modulating Gut Microbiota in Dogs

Cited by 5 publications

References 49 publications

Beneficial effects of American ginseng (Panax quinquefolius L.) extract residue as a feed additive on production, health status, and gastrointestinal bacteria in sika deer (Cervus nippon)

Beneficial effects of American ginseng (Panax quinquefolius L.) extract residue as a feed additive on production, health status, and gastrointestinal bacteria in sika deer (Cervus nippon)

Microbiota of healthy dogs demonstrate a significant decrease in richness and changes in specific bacterial groups in response to supplementation with resistant starch, but not psyllium or methylcellulose, in a randomized cross-over trial

Effect of fermented total mixed rations on rumen microbial communities and serum metabolites in lambs

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