Red fluorescent BODIPY-based nanoparticles for targeted cancer imaging-guided photodynamic therapy

Kim, Chanwoo; Mai, Duy Khuong; Kim, Won-Jin; Badon, Isabel Wen; Jo, Jinwoong; Kang, Dongho; Kim, Seok-Jun; Kim, Ho-Joong; Yang, Jaesung

doi:10.1039/d3bm01520c

Biomater. Sci.

2024

DOI: 10.1039/d3bm01520c

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Red fluorescent BODIPY-based nanoparticles for targeted cancer imaging-guided photodynamic therapy

Chanwoo Kim,

Duy Khuong Mai,

Won-Jin Kim

et al.

Abstract: Imaging-guided diagnosis and treatment of cancer hold potential to significantly improve therapeutic accuracies and efficacies.

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Smart Nanoassembly Enabling Activatable NIR Fluorescence and ROS Generation with Enhanced Tumor Penetration for Imaging‐Guided Photodynamic Therapy

Chen,

Li,

Yue

et al. 2024

Advanced Materials

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Fluorescence imaging‐guided photodynamic therapy (FIG‐PDT) holds promise for cancer treatment, yet challenges persist in poor imaging quality, phototoxicity, and insufficient anti‐tumor effect. Herein, we report a novel nanoplatform, LipoHPM, designed to address these challenges. Our approach employs an acid‐sensitive amine linker to connect a biotin‐modified hydrophilic polymer (BiotinPEG) with a hydrophobic photosensitizer (MBA), forming OFF‐state BiotinPEG‐MBA (PM) micelles via an aggregation‐caused quenching (ACQ) effect. These micelles are then co‐loaded with the tumor penetration enhancer hydralazine (HDZ) into pH‐sensitive liposomes (LipoHPM). Leveraging the ACQ effect, LipoHPM is silent in both fluorescence and reactive oxygen species (ROS) generation during blood circulation but restores both properties upon disassembly. Following intravenous injection in tumor‐bearing mice, LipoHPM actively targets tumor cells overexpressing biotin‐receptors, contributing to enhanced tumor accumulation. Upon cellular internalization, LipoHPM disassembles within lysosomes, releasing HDZ to enhance tumor penetration and inhibit tumor metastasis. Concurrently, the micelles activate fluorescence for tumor imaging and boost the production of both type‐I and type‐II ROS for tumor eradication. Therefore, the smart LipoHPM synergistically integrates near‐infrared emission, activatable tumor imaging, robust ROS generation, efficient anti‐tumor and anti‐metastasis activity, successfully overcoming limitations of conventional photosensitizers and establishing itself as a promising nanoplatform for potent FIG‐PDT applications.This article is protected by copyright. All rights reserved

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Smart Nanoassembly Enabling Activatable NIR Fluorescence and ROS Generation with Enhanced Tumor Penetration for Imaging‐Guided Photodynamic Therapy

Chen,

Li,

Yue

et al. 2024

Advanced Materials

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show abstract

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Red fluorescent BODIPY-based nanoparticles for targeted cancer imaging-guided photodynamic therapy

Abstract: Imaging-guided diagnosis and treatment of cancer hold potential to significantly improve therapeutic accuracies and efficacies.

Cited by 1 publication

References 54 publications

Smart Nanoassembly Enabling Activatable NIR Fluorescence and ROS Generation with Enhanced Tumor Penetration for Imaging‐Guided Photodynamic Therapy

Smart Nanoassembly Enabling Activatable NIR Fluorescence and ROS Generation with Enhanced Tumor Penetration for Imaging‐Guided Photodynamic Therapy

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