Red-emitting gold nanoclusters for rapid fluorescence sensing of tryptophan metabolites

Ungor, Ditta; Horváth, Krisztián; Dékány, Imre; Csapó, Edit

doi:10.1016/j.snb.2019.03.026

Cited by 41 publications

(21 citation statements)

References 39 publications

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“…The ultra-facile, one-step synthetic processes are in focus of interest, where the execution of the reactions is very convenient, rapid, and mild, exempted from the application of harsh reducing agent, special ambience and media, and high pressure. However, numerous articles were published for the preparation of biocompatible Au NCs that were synthesized by template-assisted preparation protocols while using proteins and peptides [75,76], polymers [77], DNA [78], dendrimers [79], etc., but only a few publications present the possible applicability of simple amino acids as reducing and stabilizing agents.…”

Section: Synthetic Routes Of Amino Acid-reduced Fluorescent Au Ncsmentioning

confidence: 99%

“…Forasmuch, this article is limited to detailed descriptions of the direct interaction between small amines and thiols, only the brief introduction of the mechanism of the protein-tetrachloroaurate(III) reaction is as follows, because the peptides can be considered as large-sized biocompatible thiolates and amines. Several articles can be found on the syntheses of protein-stabilized Au NCs while using the BSA [111,112,113], HSA [114,115], LYZ [116,117,118,119,120], trypsin [121], pepsin [122], or immunoglobulin [76]. The typically red-emitting cluster synthesis is carried out under basic conditions (~pH 12) and 10–20-fold protein excess is applied at ca.…”

Section: Fabrication Protocols Of Thiolate-protected Au Nanohybridmentioning

confidence: 99%

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Reduction of Tetrachloroaurate(III) Ions With Bioligands: Role of the Thiol and Amine Functional Groups on the Structure and Optical Features of Gold Nanohybrid Systems

2019

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In this review, the presentation of the synthetic routes of plasmonic gold nanoparticles (Au NPs), fluorescent gold nanoclusters (Au NCs), as well as self-assembled Au-containing thiolated coordination polymers (Au CPs) was highlighted. We exclusively emphasize the gold products that are synthesized by the spontaneous interaction of tetrachloroaurate(III) ions (AuCl4¯) with bioligands using amine and thiolate derivatives, including mainly amino acids. The dominant role of the nature of the applied reducing molecules as well as the experimental conditions (concentration of the precursor metal ion, molar ratio of the AuCl4¯ ions and biomolecules; pH, temperature, etc.) of the syntheses on the size and structure-dependent optical properties of these gold nanohybrid materials have been summarized. While using the same reducing and stabilizing biomolecules, the main differences on the preparation conditions of Au NPs, Au NCs, and Au CPs have been interpreted and the reducing capabilities of various amino acids and thiolates have been compared. Moreover, various fabrication routes of thiol-stabilized plasmonic Au NPs, as well as fluorescent Au NCs and self-assembled Au CPs have been presented via the formation of –(Au(I)-SR)n– periodic structures as intermediates.

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Section: Synthetic Routes Of Amino Acid-reduced Fluorescent Au Ncsmentioning

confidence: 99%

Section: Fabrication Protocols Of Thiolate-protected Au Nanohybridmentioning

confidence: 99%

Reduction of Tetrachloroaurate(III) Ions With Bioligands: Role of the Thiol and Amine Functional Groups on the Structure and Optical Features of Gold Nanohybrid Systems

2019

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“…The mechanism of fluorescence quenching of Cu NCs caused by p-AAB was analyzed. Basically, the fluorescence quenching process could be divided into two different mechanisms, a static quenching mechanism (ground state complex formation) and a dynamic quenching mechanism (diffusion collision) [ 38 ]. In general, there are many possible mechanisms that contribute to the quenching of fluorescence emission from nanomaterials, such as fluorescence resonance energy transfer (Forster resonance energy transfer, FRET), internal filtering effect (inner filter effect, IFE) and electron transfer (electron transfer, ET) [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Highly Luminescent Copper Nanoclusters Stabilized by Ascorbic Acid for the Quantitative Detection of 4-Aminoazobenzene

Li³

et al. 2020

Nanomaterials

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As one of the widely studied metal nanoclusters, the preparation of copper nanoclusters (Cu NCs) by a facile method with high fluorescence performance has been the interest of researchers. In this paper, a simple, green, clean, and time-saving chemical etching method was used to synthesize water-soluble Cu NCs using ascorbic acid (AA) as the reducing agent. The as-prepared Cu NCs showed strong green fluorescence (with a quantum yield as high as 33.6%) and high ion stability, and good antioxidant activity as well. The resultant Cu NCs were used for the detection of 4-aminoazobenzene (one of 24 kinds of prohibited textile compounds) in water with a minimum detection limit of 1.44 μM, which has good potential for fabric safety monitoring.

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“…Previous studies have demonstrated that the increase in peak intensity and the shift of peak position can be attributed to the formation of Hb-AuNCs. Based on the results of the FTIR spectra, the conjugation between Hb and AuNCs was successfully obtained [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Hemoglobin-Conjugated Gold Nanoclusters for Qualitative Analysis of Haptoglobin Phenotypes

et al. 2020

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Designing a facile and rapid detection method for haptoglobin (Hp) phenotypes in human blood plasma is urgently needed to meet clinic requirements in hemolysis theranostics. In this work, a novel approach to qualitatively analyze Hp phenotypes was developed using a fluorescent probe of gold nanoclusters (AuNCs). Hemoglobin-conjugated (Hb)-AuNCs were successfully synthesized with blue-green fluorescence and high biocompatibility via one-pot synthesis. The fluorescence of Hb-AuNCs comes from the ligand-metal charge transfer between surface ligands of Hb and the gold cores with high oxidation states. The biocompatibility assays including cell viability and fluorescence imaging, demonstrated high biocompatibility of Hb-AuNCs. For the qualitative analysis, three Hp phenotypes in plasma, Hp 1-1, Hp 2-1, and Hp 2-2, were successfully discriminated according to changes in the fluorescence intensity and peak position of the maximum intensity of Hb-AuNCs. Our work provides a practical method with facile and rapid properties for the qualitative analysis of three Hp phenotypes in human blood plasma.

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Red-emitting gold nanoclusters for rapid fluorescence sensing of tryptophan metabolites

Cited by 41 publications

References 39 publications

Reduction of Tetrachloroaurate(III) Ions With Bioligands: Role of the Thiol and Amine Functional Groups on the Structure and Optical Features of Gold Nanohybrid Systems

Reduction of Tetrachloroaurate(III) Ions With Bioligands: Role of the Thiol and Amine Functional Groups on the Structure and Optical Features of Gold Nanohybrid Systems

Highly Luminescent Copper Nanoclusters Stabilized by Ascorbic Acid for the Quantitative Detection of 4-Aminoazobenzene

Hemoglobin-Conjugated Gold Nanoclusters for Qualitative Analysis of Haptoglobin Phenotypes

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