Red Deer Umbilical Cord-Derived Stem Cell Conditioned Media Combined With Ablative Resurfacing of the Face

Hoss, Elika; Kollipara, Ramya; Alhaddad, Marwan; Boen, Monica; Goldman, Mitchel P.

doi:10.36849/jdd.2020.5246

Cited by 6 publications

(7 citation statements)

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“…This review concentrated on the use of growth factor monotherapy for facial rejuvenation. Besides their use as monotherapy, various growth factor preparations have also been combined with other skin‐rejuvenating treatments, such as lasers, 9,10,67–70 microneedling, 22,24–26,71 radiofrequency, 72 and chemical peels to amplify the results reported in this review. We also recognize that preparations containing growth factors have evolved substantially since the first results were reported 20 years ago.…”

Section: Discussionmentioning

confidence: 99%

“…A more recent systematic review by Miller-Kobisher et al 66 that included five trials in our review also supported the effectiveness of the topical application of recombinant EGF formulations for facial rejuvenation, while noting the variety of study designs supporting current evidence.This review concentrated on the use of growth factor monotherapy for facial rejuvenation. Besides their use as monotherapy, various growth factor preparations have also been combined with other skin-rejuvenating treatments, such as lasers,9,10,[67][68][69][70] microneedling,22,[24][25][26]71 radiofrequency,72 and chemical peels to amplify the results reported in this review. We also recognize thatpreparations containing growth factors have evolved substantially since the first results were reported 20 years ago.…”

mentioning

confidence: 99%

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Topical growth factor preparations for facial skin rejuvenation: A systematic review

Quinlan

Ghanem

Hassan

2023

J of Cosmetic Dermatology

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Topical growth factor preparations for facial skin rejuvenation: A systematic review

Quinlan

Ghanem

Hassan

2023

J of Cosmetic Dermatology

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“…Topical application of growth factors has been used in combination with laser resurfacing and microneedling, two treatments that may permit better penetration of growth factor preparations through the stratum corneum to their receptor sites. In laser resurfacing, the post‐treatment application of topical growth factors has shown to provide benefit in accelerated wound healing 30‐39 . Similarly, the use of microneedling in combination with growth factors has shown benefit in several studies, although the data are more limited 40‐44 …”

Section: Discussionmentioning

confidence: 99%

“…In laser resurfacing, the post-treatment application of topical growth factors has shown to provide benefit in accelerated wound healing. [30][31][32][33][34][35][36][37][38][39] Similarly, the use of microneedling in combination with growth factors has shown benefit in several studies, although the data are more limited. [40][41][42][43][44] Other studies have used the VISIA complexion-analysis system to evaluate the efficacy of growth factor preparations for facial skin rejuvenation.…”

Section: Discussionmentioning

confidence: 99%

Topical growth factors and home‐based microneedling for facial skin rejuvenation

Quinlan

Ghanem

Hassan

2021

J of Cosmetic Dermatology

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Background Cosmeceutical products are an important therapeutic option for facial rejuvenation. Of these, topical application of growth factors has been shown to increase dermal collagen synthesis, improve skin texture, and reduce fine lines and wrinkles. Limited data exist for the use of growth factors in combination with microneedling. Objective This prospective, single‐center, uncontrolled study evaluated the efficacy of topical growth factor treatment in conjunction with transdermal delivery of growth factors via home‐based microneedling for facial skin rejuvenation. Patients/Methods Eleven healthy female individuals aged 33–61 years, with mild‐moderate facial wrinkling were included in the study. Over 3 months, participants received twice‐daily application of a topical recombinant human growth factor preparation (SkinGenuity® Regenerative and Reparative Serums) along with twice‐weekly transdermal delivery of growth factors using a home‐based microneedling (0.2 mm) device. Objective skin analysis (VISIA®) and a subjective patient‐reported outcome (FACE‐Q®) assessment measuring satisfaction with appearance were performed at baseline and after 3 months. Results Objective skin analysis showed a significant improvement in skin texture (17.6%, p < 0.001), wrinkles (17.3%, p < 0.001), red areas (12.4%, p =0.004), and brown spots (6.0%, p =0.03) at 3 months follow‐up. FACE‐Q scales showed a significant improvement from baseline, including satisfaction with skin, facial appearance, nasolabial folds, cheeks, and lower face/jawline (all p ≤ 0.02). Numerical improvement in adverse effects related to skin was also observed (p = 0.07). No serious adverse effects were reported. Conclusions Three months of twice‐daily topical growth factor treatment in conjunction with transdermal delivery of growth factors via microneedling improved skin analysis parameters and participant‐reported outcome measures, indicative of facial skin rejuvenation.

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“…Notably, recent studies proposed using the factors secreted by hUC-SCs, rather than cell transplantation, for regenerative medicine [100][101][102][103]. The secreted GFs are referred to as the secretome of the hUC-SCs, can be isolated from culture media, and induce biological effects similar to SC therapy.…”

Section: Immunomodulationmentioning

confidence: 99%

Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine

Rodríguez-Eguren

Gómez-Álvarez²,

Francés-Herrero

et al. 2022

IJMS

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There are several conditions that lead to female infertility, where traditional or conventional treatments have limited efficacy. In these challenging scenarios, stem cell (SC) therapies have been investigated as alternative treatment strategies. Human umbilical cord (hUC) mesenchymal stem cells (hUC-MSC), along with their secreted paracrine factors, extracts, and biomolecules, have emerged as promising therapeutic alternatives in regenerative medicine, due to their remarkable potential to promote anti-inflammatory and regenerative processes more efficiently than other autologous treatments. Similarly, hUC blood derivatives, such as platelet-rich plasma (PRP), or isolated plasma elements, such as growth factors, have also demonstrated potential. This literature review aims to summarize the recent therapeutic advances based on hUC-MSCs, hUC blood, and/or other plasma derivatives (e.g., extracellular vesicles, hUC-PRP, and growth factors) in the context of female reproductive medicine. We present an in-depth analysis of the principal molecules mediating tissue regeneration, compiling the application of these therapies in preclinical and clinical studies, within the context of the human reproductive tract. Despite the recent advances in bioengineering strategies that sustain delivery and amplify the scope of the therapeutic benefits, further clinical trials are required prior to the wide implementation of these alternative therapies in reproductive medicine.

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Red Deer Umbilical Cord-Derived Stem Cell Conditioned Media Combined With Ablative Resurfacing of the Face

Cited by 6 publications

References 0 publications

Topical growth factor preparations for facial skin rejuvenation: A systematic review

Topical growth factor preparations for facial skin rejuvenation: A systematic review

Topical growth factors and home‐based microneedling for facial skin rejuvenation

Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine

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