Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis

Mahendra, Jaideep; Mahendra, Little; Sharma, Vivek; Alamoudi, Ahmed; Bahammam, Hammam Ahmed; Mugri, Maryam H.; Bahammam, Sarah Ahmed; Bahammam, Maha A.; Zidane, Bassam; Nayaki, Rao P. Abirami; Muralidharan, Janani; Dave, Pavithra H; Balaji, Thodur Madapusi; Bhandi, Shilpa; Patil, Shankargouda

doi:10.1016/j.identj.2022.10.003

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…Published by Francis Academic Press, UK -5-(APO), such as premature rupture of membranes, preeclampsia, fetal intrauterine growth retardation, and preterm low birth weight infants [33][34][35][36] .xisting evidence shows that the existence of P. gingivalis can partially explain this correlation. P. gingivalis invades periodontal or maternal-fetal tissues, causing immune environment disorder and oxidative stress in systemic and placental tissues, causing poor remodeling of uterine spiral arteries and placental vascular endothelial dysfunction leading to APO [37] .…”

Section: Porphyromonas Gingivalis and The Reproductive Systemmentioning

confidence: 99%

Research progress on the correlation between porphyromonas gingivalis and human diseases

2023

IJFM

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Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that is closely related to periodontal diseases and has strong virulence. Studies have shown that in addition to damaging oral health, it also has a serious impact on general health. This article reviews the research progress of the relationship between Porphyromonas gingivalis and human diseases, which is helpful to explore new treatment strategies for related diseases.

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Section: Porphyromonas Gingivalis and The Reproductive Systemmentioning

confidence: 99%

Research progress on the correlation between porphyromonas gingivalis and human diseases

2023

IJFM

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“…A number of epidemiological studies and intervention trials have attempted to demonstrate the relationships between maternal periodontal disorders and adverse pregnancy outcomes (APO), for which periodontal diseases are considered an important risk factor, including fetal growth restriction, gestational diabetes, low birthweight, preterm birth and pre-eclampsia [ 45 ]. For instance, a new study exploring the levels of periodontal red-complex bacteria (RCB) in pregnant pre-eclamptic women with periodontal diseases, potentiating the pathophysiology of a bacterial association in both periodontitis and pre-eclampsia [ 46 ]. However, restraining the periodontal bacterial load in pregnant women via good oral hygiene can significantly reduce the putative risk of adverse pregnancy outcomes including pre-eclampsia [ 46 ].…”

Section: Dental Aging-related Diseasesmentioning

confidence: 99%

“…For instance, a new study exploring the levels of periodontal red-complex bacteria (RCB) in pregnant pre-eclamptic women with periodontal diseases, potentiating the pathophysiology of a bacterial association in both periodontitis and pre-eclampsia [ 46 ]. However, restraining the periodontal bacterial load in pregnant women via good oral hygiene can significantly reduce the putative risk of adverse pregnancy outcomes including pre-eclampsia [ 46 ]. Thus, orisbacteria in saliva could be exploited as a non-invasive diagnostic indicator for early detection of oral and systemic disorders, while other therapeutic solutions including antimicrobial photodynamic therapy, antimicrobial peptides probiotics, green tea polyphenol and cold atmospheric plasma therapy are used to inhibit the growth of biofilm formation by oral bacteria [ 47 ].…”

Section: Dental Aging-related Diseasesmentioning

confidence: 99%

A New Landscape of Human Dental Aging: Causes, Consequences, and Intervention Avenues

Xie¹,

Chen²,

Shen³

et al. 2022

Aging and disease

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Aging is accompanied by physical dysfunction and physiologic degeneration that occurs over an individual's lifetime. Human teeth, like many other organs, inevitably undergo chronological aging and agerelated changes throughout the lifespan, resulting in a substantial need for preventive, restorative as well as periodontal dental care. This is particularly the case for seniors at 65 years of age and those older but economically disadvantaged. Dental aging not only interferes with normal chewing and digestion, but also affects daily appearance and interpersonal communications. Further dental aging can incur the case of multiple disorders such as oral cancer, encephalitis, and other systemic diseases. In the next decades or even hundreds of years, the proportion of the elderly in the global population will continue to rise, a tendency that attracts increasing attention across multiple scientific and medical disciplines. Dental aging will bring a variety of problems to the elderly themselves and poses serious challenges to the medical profession and social system. A reduced, but functional dentition comprising 20 teeth in occlusion has been proposed as a measurement index of successful dental aging. Healthy dental aging is critical to healthy aging, from both medical and social perspectives. To date, biomedical research on the causes, processes and regulatory mechanisms of dental aging is still in its infancy. In this article, updated insights into typical manifestations, associated pathologies, preventive strategies and molecular changes of dental aging are provided, with future research directions largely projected.

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“…For example, a high GNB load in periodontitis has been associated with adverse pregnancy outcomes and preeclampsia (8), with the progression of liver disease to liver cirrhosis (9), and these periodontopathogens have been detected in coronary plaque from coronary artery disease patients (10).…”

Section: Introductionmentioning

confidence: 99%

Unveiling Oral Anaerobic Bacteria Outer Membrane Vesicles: A Comprehensive Systematic Review

Castro-Vargas,

Barloy-Hubler,

Acuña-Amador

2024

Odovtos - Int J Dent Sc

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Extracellular vesicles (EV) are spherical structures limited by membranes and shed by several cell types. Specifically, outer membrane vesicles (OMVs) are nanometric particles constitutively produced by Gram-negative bacteria (GNB) under different environmental conditions. OMVs are biologically active; they are loaded with selected lipids, polysaccharides, proteins, and even different types of nucleic acids. OMVs from pathogenic oral bacteria play key roles in pathogen-host interactions, constituting a possible link between oral health and systemic disease. OMVs participate in adhesion, invasion, and damage to cells, as well as in modulating the host's immune response, biofilm formation, and promotion of virulence. The objective of this systematic review was to collect, analyze and synthesize the knowledge available on literature reviews on OMVs of the most studied pathogenic oral anaerobic GNB. This information was classified into the following categories: induction of vesiculation and biogenesis, its liberation from the parental cell, content, internalization by another host cell, and the interaction with the host cell. It was found that the most studied OMVs are those of Porphyromonas gingivalis and Bacteroides spp. and, to a lesser extent, Aggregatibacter spp., and Treponema spp. This systematic review provides a synthesis of the current knowledge regarding OMVs, with emphasis on the information available for periodontopathogens.

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Red-Complex Bacterial Levels in Pregnant Women With Preeclampsia and Chronic Periodontitis

Cited by 5 publications

References 27 publications

Research progress on the correlation between porphyromonas gingivalis and human diseases

Research progress on the correlation between porphyromonas gingivalis and human diseases

A New Landscape of Human Dental Aging: Causes, Consequences, and Intervention Avenues

Unveiling Oral Anaerobic Bacteria Outer Membrane Vesicles: A Comprehensive Systematic Review

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