Red cell volume in respiratory distress syndrome

Usher, Robert H.; Saigal, Saroj; O’Neill, Allison F.; Chua, L.C.; Surainder, Y. A.

doi:10.1203/00006450-197108000-00183

Cited by 4 publications

(1 citation statement)

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“…[8][9][10] Other studies indicated that ECC prevented placental transfusion and resulted in more respiratory distress syndrome among preterm infants. [11][12][13] Importantly, in settings with a high prevalence of HIV infection, immediate CC has been thought to reduce the risk of mother-to-child transmission. Furthermore, active management of third-stage labor, including use of oxytocin, together with ECC within 30 to 60 seconds and controlled cord traction, is considered important in the prevention of postpartum bleeding.…”

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confidence: 99%

Neonatal Outcome Following Cord Clamping After Onset of Spontaneous Respiration

et al. 2014

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BACKGROUND AND OBJECTIVE: Evolving data indicate that cord clamping (CC) beyond 30 to 60 seconds after birth is of benefit for all infants. Recent experimental data demonstrated that ventilation before CC improved cardiovascular stability by increasing pulmonary blood flow. The objective was to describe the relationship between time to CC, onset of spontaneous respirations (SR), and 24-hour neonatal outcome. METHODS: In a rural Tanzanian hospital, trained research assistants, working in shifts, have observed every delivery (November 2009–February 2013) and recorded data including time interval from birth to SR and CC, fetal heart rate, perinatal characteristics and outcome (normal, death, admission). RESULTS: Of 15 563 infants born, 12 780 (84.3%) initiated SR at 10.8 ± 16.7 seconds, and CC occurred at 63 ± 45 seconds after birth. Outcomes included 12 730 (99.7%) normal, 31 deaths, and 19 admitted; 11 967 were of birth weight (BW) ≥2500 g and 813 <2500 g. By logistic modeling, the risk of death/admission was consistently higher if CC occurred before SR. Infants of BW <2500 g were more likely to die or be admitted. The risk of death/admission decreased by 20% for every 10-second delay in CC after SR; this risk declined at the same rate in both BW groups. CONCLUSIONS: Healthy self-breathing neonates are more likely to die or be admitted if CC occurs before or immediately after onset of SR. These clinical observations support the experimental findings of a smoother cardiovascular transition when CC is performed after initiation of ventilation.

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confidence: 99%