Red Cell Survival Estimated by Radioactive Chromium in Hepatobiliary Disease

Katz, R; Velasco, Marta; Guzman, Cesar; Alessandri, H

doi:10.1016/s0016-5085(64)80101-3

Cited by 16 publications

(5 citation statements)

References 18 publications

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“…Chromium-51 RBC survivals in the patients with Wilson's disease were only slightly longer than those reported by Katz, Velasco, Guzman, and Alessandri (1964) (mean T1/2 of 17.4 days) in 13 patients with alcoholic cirrhosis whose liver function was more severely disturbed. Richmond, Donaldson, Williams, Hamilton, and Hutt (1967) found marked reductions in 61Cr RBC survival in 15 patients from Uganda with splenomegaly ofunknown cause.…”

Section: Discussioncontrasting

confidence: 51%

Hypersplenism in Wilson's disease

Strickland¹,

Chang²,

Beckner³

1972

Gut

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Section: Discussioncontrasting

confidence: 51%

Hypersplenism in Wilson's disease

Strickland¹,

Chang²,

Beckner³

1972

Gut

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“…Moreover, the disease may develop into liver failure ( i.e. CSHB) due to various factors, such as HBV mutations [35] , [36] , coinfection with other hepatotropic viruses [37] – [42] , over-work, alcohol overdose [43] , long-term corticosteroid treatment [44] , and bacterial infections [45] , during the long course of the disease. Although the application of newly developed drugs with an artificial liver support system is effective in some cases, the mortality rate of CSHB may still reach 80%–100% in patients with stage III–IV hepatic encephalopathy [46] .…”

Section: Discussionmentioning

confidence: 99%

Clinical Usefulness of Measuring Red Blood Cell Distribution Width in Patients with Hepatitis B

2012

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BackgroundRed blood cell distribution width (RDW), an automated measure of red blood cell size heterogeneity (e.g., anisocytosis) that is largely overlooked, is a newly recognized risk marker in patients with cardiovascular diseases, but its role in persistent viral infection has not been well-defined. The present study was designed to investigate the association between RDW values and different disease states in hepatitis B virus (HBV)-infected patients. In addition, we analyzed whether RDW is associated with mortality in the HBV-infected patients.Methodology/Principal FindingsOne hundred and twenty-three patients, including 16 with acute hepatitis B (AHB), 61 with chronic hepatitis B (CHB), and 46 with chronic severe hepatitis B (CSHB), and 48 healthy controls were enrolled. In all subjects, a blood sample was collected at admission to examine liver function, renal function, international normalized ratio and routine hematological testing. All patients were followed up for at least 4 months. A total of 10 clinical chemistry, hematology, and biochemical variables were analyzed for possible association with outcomes by using Cox proportional hazards and multiple regression models. RDW values at admission in patients with CSHB (18.30±3.11%, P<0.001), CHB (16.37±2.43%, P<0.001) and AHB (14.38±1.72%, P<0.05) were significantly higher than those in healthy controls (13.03±1.33%). Increased RDW values were clinically associated with severe liver disease and increased 3-month mortality rate. Multivariate analysis demonstrated that RDW values and the model for end-stage liver disease score were independent predictors for mortality (both P<0.001).ConclusionRDW values are significantly increased in patients with hepatitis B and associated with its severity. Moreover, RDW values are an independent predicting factor for the 3-month mortality rate in patients with hepatitis B.

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“…The haemoglobin rose from 6-8 g to 12-5 g% and the PCV rose from 20% to 36%, and the Coombs test became negative. Red cell survival is not usually affected by steroid therapy in cirrhosis (Williams and Billing, 1961;Katz et al, 1964). Two patients (cases 5 and 6) had evidence, from surface counting, of splenic sequestration of red cells of a degree which suggested that splenectomy would influence the haemolytic process.…”

Section: Discussionmentioning

confidence: 96%

Red cell survival in biliary cirrhosis

Hume¹,

Williamson²,

Whitelaw³

1970

J Clin Pathol

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SYNOPSIS Studies were carried out on eight patients with primary biliary cirrhosis. Four patients were found to have a haemolytic anaemia; one had Coombs red cell antibodies. Two patients had evidence of splenic sequestration of red cells using the radio-chromium technique. There was a significant correlation between the red cell survival and the bromsulphthalein retention test and the red cell survival and the serum level of bilirubin. It was concluded that the anaemia of cirrhosis of the liver, including primary biliary cirrhosis, may be due to a number of mechanisms and a unifying hypothesis based on the degree of liver dysfunction is suggested.

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Red Cell Survival Estimated by Radioactive Chromium in Hepatobiliary Disease

Cited by 16 publications

References 18 publications

Hypersplenism in Wilson's disease

Hypersplenism in Wilson's disease

Clinical Usefulness of Measuring Red Blood Cell Distribution Width in Patients with Hepatitis B

Red cell survival in biliary cirrhosis

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