Red cell oxygen transport in man in relation to gender and age

Humpeler, Egon; Vogel, Sylvia; Schobersberger, Wolfgang; Mairbäurl, Heimo

doi:10.1016/0047-6374(89)90035-3

Cited by 25 publications

(19 citation statements)

References 31 publications

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“…This difference between the sexes did not exist in preadolescents or after menopause 9. The subjects in our study did not show ventilatory differences between the sexes, even in the young subjects.…”

Section: Discussioncontrasting

confidence: 54%

Sex-linked differences in pulse oxymetry

et al. 2007

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The difference between genders has generated increasing interest in recent years. It is well known that women and men show differences in their respiratory system: different red blood cell counts, haemoglobin and 2,3-diphosphoglycerate plasma concentrations. Recently, further differences have been found in the ventilatory response to hypoxia and exercise and the evolution of some respiratory illnesses. In this study it was found that during rest at sea level, the haemoglobin oxygen saturation, as measured by pulse oxymetry, is slightly higher in women than in men (98.6 (SD 1.1)% versus 97.9 (SD 0.9)%; p = 0.001). These findings are consistent with other studies, which found gender differences in the transcutaneous or tissue PaO(2). The difference in oxygen saturation is not related to differences in ventilation. The disparity is modest and does not seem to produce great differences in the oxygen content of arterial blood, but combined with the different affinity of haemoglobin for oxygen or different metabolic rate, may play a role in the course of elite competition sports, high altitude ascents or the evaluation of critically ill patients. Further studies are needed to establish the degree, extent and clinical importance of these differences in the saturation of haemoglobin.

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Section: Discussioncontrasting

confidence: 54%

Sex-linked differences in pulse oxymetry

et al. 2007

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“…van Klaveren [16] describes a similar difference, but no test for statistical significance was performed. Differences in hemoglobin affinity for oxygen and in oxygen transport have been reported between sex and could be involved [40,41], as could the stimulating effects of progesterone on breathing [27, 28]. …”

Section: Discussionmentioning

confidence: 99%

Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers

Goldberg

Ollila

et al. 2017

PLoS ONE

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IntroductionA previous study has suggested that the Human Leukocyte Antigen (HLA) allele DQB1*06:02 affects hypoxic ventilatory response (HVR) but not hypercapnic ventilatory response (HCVR) in an Asian population. The current study evaluated the relationship in Caucasians and Asians. In addition we assessed whether gender or polymorphisms in genes participating in the control of breathing affect HVR and HCVR.MethodsA re-breathing system was used to measure HVR and HCVR in 551 young adults (56.8% Caucasians, 30% Asians). HLA-DQB1*06:02 and tagged polymorphisms and coding variants in genes participating in breathing (PHOX2B, GPR4 and TASK2/KCNK5) were analyzed. The associations between HVR/HCVR and HLA-DQB1*06:02, genetic polymorphisms, and gender were evaluated using ANOVA or frequentist association testing with SNPTEST.ResultsHVR and gender are strongly correlated. HCVR and gender are not. Mean HVR in women was 0.276±0.168 (liter/minute/%SpO2) compared to 0.429±0.266 (liter/minute/%SpO2) in men, p<0.001 (55.4% higher HVR in men). Women had lower baseline minute ventilation (8.08±2.36 l/m vs. 10.00±3.43l/m, p<0.001), higher SpO2 (98.0±1.3% vs. 96.6±1.7%, p<0.001), and lower EtCO2 (4.65±0.68% vs. 4.82±1.02%, p = 0.025). One hundred and two (18.5%) of the participants had HLA-DQB1*06:02. No association was seen between HLA-DQB1*06:02 and HVR or HCVR. Genetic analysis revealed point wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and HCVR.ConclusionsThis is the largest study to date reporting the relationship between gender and HVR/ HCVR and the first study assessing the association between genetic polymorphisms in humans and HVR/HCVR. The data suggest that gender has a large effect on hypoxic breathing response.

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“…It is interesting that despite the sex differences mentioned above, we observe a similar reduction in VO 2peak in women compared to studies done in men. However, it has been demonstrated that women aged between 20 and 40 years have a 2 µmol/g Hb higher 2,3‐DPG concentration than matched males of similar age, and this induces a rightward shift of the oxygen dissociation curve, which gives a better tissue oxygen delivery. However, caution is required since some evidence implies that the rightward shift, the Bohr effect, may only play a limited role here during higher intensity exercise .…”

Section: Discussionmentioning

confidence: 99%