Red Cell Injury Assessed in a Numeric Model of a Peripheral Dialysis Needle

Wachter, Dirk S. De; Verdonck, Pascal; Verhoeven, Ronny; Hombrouckx, R

doi:10.1097/00002480-199609000-00041

Cited by 28 publications

(15 citation statements)

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“…The benefit of this model is that the calculated damage is much higher than the Average Shear Stress Model, however, there are still instances that damage to RBCs is seen to be higher than platelets; which is a result suggesting this model is not fully accurate. It has been found in various references (D. De Wachter and Verdonck, 2002;D. S. De Wachter et al, 1996;M.…”

Section: Discussionmentioning

confidence: 99%

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Towards computational prediction of flow-induced damage of blood cells using a time-accumulated model

Gharaie

Mosadegh

Morsi

2017

JBSE

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Currently, there is no definite mathematical model to evaluate damage to blood cells, especially for cardiovascular devices with complex flow profiles due to turbulent flow and moving parts. This paper describes a finite volume technique that can more accurately predict damage of red blood cells and platelets by tracking their shear stress history and calculating their accumulated damage. Three standard power-law models for calculating the damage to the blood cells are compared to a novel modified model which takes into account a particle accumulated history and corrects for issues in previous models that miscount for decreasing shear stress. As an example, the damage to blood cells are determined for specific streamlines along a prosthetic polymer-based aortic valve, which is a cardiac device with low levels of damage, allowing for the sensitivity of these models to be tested. The results suggest that the new modified model provides the most accurate prediction of damage.

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Section: Discussionmentioning

confidence: 99%

“…Hence, the risk of hemolysis in patients with a cardiovascular medical device needs to be evaluated. In this regard, it has been found in various references (D. De Wachter and Verdonck, 2002;D. S. De Wachter et al, 1996;M.…”

Section: Introductionmentioning

confidence: 97%

Towards computational prediction of flow-induced damage of blood cells using a time-accumulated model

Gharaie

Mosadegh

Morsi

2017

JBSE

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“…Neointima formation in stents has been shown to be related to wall shear stress as well [37]. In tubing used during dialysis, the high shear rate at the needle may lead to problems for erythrocytes [38], but it should not be disregarded that the wall shear stress of the tubing is the most critical issue for platelet activation.…”

Section: Iso 10993 Requirements For Testing Of Medical Devices: Ismentioning

confidence: 99%

Obstacles in Haemocompatibility Testing

Oeveren¹

2013

Scientifica

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ISO 10993-4 is an international standard describing the methods of testing of medical devices for interactions with blood for regulatory purpose. The complexity of blood responses to biomaterial surfaces and the variability of blood functions in different individuals and species pose difficulties in standardisation. Moreover, in vivo or in vitro testing, as well as the clinical relevance of certain findings, is still matter of debate. This review deals with the major remaining problems, including a brief explanation of surface interactions with blood, the current ISO 10993 requirements for testing, and the role of in vitro test models. The literature is reviewed on anticoagulation, shear rate, blood-air interfaces, incubation time, and the importance of evaluation of the surface area after blood contact. Two test categories deserve further attention: complement and platelet function, including the effects on platelets from adhesion proteins, venipuncture, and animal derived- blood. The material properties, hydrophilicity, and roughness, as well as reference materials, are discussed. Finally this review calls for completing the acceptance criteria in the ISO standard based on a panel of test results.

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“…From this it can be understood that the stresses acting on the blood cell near the tip are lot more than the stresses acting inside the needle near the wall. The shear stress increases with increase in blood flow [22,19] .…”

Section: Effect Of Shearing Stress On Blood Cellsmentioning

confidence: 99%

“…The main cause of hemolysis in needles is the fluid stress acting on the blood cells [22]. It is found that the maximum stress acting on the blood cells passing through a needle is at the entrance of the needle.…”

Section: Introductionmentioning

confidence: 99%

Hemolysis in needles.

Kommidi¹

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Red Cell Injury Assessed in a Numeric Model of a Peripheral Dialysis Needle

Cited by 28 publications

References 0 publications

Towards computational prediction of flow-induced damage of blood cells using a time-accumulated model

Towards computational prediction of flow-induced damage of blood cells using a time-accumulated model

Obstacles in Haemocompatibility Testing

Hemolysis in needles.

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