Red Cell Hypoplasia, Cold Hemoglobinuria and M-Type Gamma G Serum Paraprotein and Bence Jones Proteinuria in a Patient With Lymphoproliferative Disorder

Prasad, Ananda S.; Berman, Laurence; Tranchida, Liborio; Poulik, M. D.

doi:10.1182/blood.v31.2.151.151

Cited by 7 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While an M-component behaving as a Math-Landsteiner haemolysin has not previously been described, it is well known that macroglobulins are able to act as cold agglutinins in causing haemoglobinuria (Waldenstrom 1968, Cooper & Hobbs 1970. This was also seen in a case of secondary gammapathy with an IgG protein (Prasad 1968).…”

Section: Discussionmentioning

confidence: 98%

Monoclonal Gammapathy with the M‐Component Behaving like Donath‐Landsteiner Haemolysin

Bastrup-Madsen¹,

Petersen²

1971

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

A case of benign idiopathic monoclonal gammapathy with cold sensitivity due to Donath‐Landsteiner antibody is reported. At the age of 42, the patient noticed a tendency to urticarial wheals after exposure to cold. Two years later, he began to have typical attacks of cold haemoglobinuria. At the age of 46, a haemolysin of the Donath‐Landsteiner type and increased amounts of IgG were disclosed. As the eluted M‐protein gave a positive Donath‐Landsteiner reaction, this was probably identical with the haemolysin. That the gammapathy was of the benign type was supported by the fact that no rise was seen in the M‐protein level or plasma‐cell count at a follow‐up examination 6 1/2 years after the onset of the cold sensitivity. The case is remarkable because Donath‐Landsteiner antibody has not previously been described together with a monoclonal gammapathy. The benign idiopathic monoclonal gammapathy is usually an asymptomatic condition.

show abstract

Section: Discussionmentioning

confidence: 98%

Monoclonal Gammapathy with the M‐Component Behaving like Donath‐Landsteiner Haemolysin

Bastrup-Madsen¹,

Petersen²

1971

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

show abstract

Pure Red Cell Aplasia and Lymphoma

Carloss¹

1979

JAMA

View full text Add to dashboard Cite

Acquired pure red cell aplasia associated with chronic lymphocytic leukemia

Yoo

Pierce

Lessin

1983

Cancer

View full text Add to dashboard Cite

Pure red cell aplasia (PRCA) represents selective failure of erythropoiesis in the absence of abnormalities in leukopoiesis or thrombocytopoiesis. Acquired PRCA has occurred uncommonly in chronic lymphocytic leukemia (CLL). We report six patients with non‐T‐cell CLL in which nine episodes of PRCA were observed. In six of the nine episodes, the patients had received recent oral alkylating agents; conversely, recovery from aplasia occurred in some while on alternate alkylator therapy and two patients had no pretreatment. Spontaneous occurrence and recovery, therefore, could not be excluded. Onset of PRCA may be suggested by macrocytosis, but discontinuance of therapy at its development may not prevent PRCA if, indeed, therapy is one of the causes. Supportive therapy or alkylators and prednisone permitted recovery without mortality in all six patients. The interval between onset of CLL and the recognition of first PRCA episode varied from one month to nine years (mean, 5.3 years); the duration of PRCA ranged from three to nine months (mean, 4.7 months). In addition to previously better understood causes of anemia in CLL, the uncommon occurrence of PRCA is an additional consideration in the differential diagnosis of sudden anemia in CLL.

show abstract

Red Cell Hypoplasia, Cold Hemoglobinuria and M-Type Gamma G Serum Paraprotein and Bence Jones Proteinuria in a Patient With Lymphoproliferative Disorder

Cited by 7 publications

References 12 publications

Monoclonal Gammapathy with the M‐Component Behaving like Donath‐Landsteiner Haemolysin

Monoclonal Gammapathy with the M‐Component Behaving like Donath‐Landsteiner Haemolysin

Pure Red Cell Aplasia and Lymphoma

Acquired pure red cell aplasia associated with chronic lymphocytic leukemia

Contact Info

Product

Resources

About