Red cell distribution width-to-albumin ratio is a simple promising prognostic marker in acute cholangitis requiring biliary drainage

Acehan, Fatih; Çamlı, Hüseyin; Kalkan, Çağdaş; Tez, Mesut; Demir, Burak Furkan; Altıparmak, Emin; Ateş, İhsan

doi:10.1016/j.hbpd.2023.08.005

Cited by 2 publications

(2 citation statements)

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“…[43] SIRT2 were associated with red cell distribution width and red cell distribution width was an important hematological parameter prognostic marker for acute pancreatitis. [44,45] There is growing recognition of the role of the microbiome in pancreatic disorders and altering the bacterial ecology in the gut has the potential to be a potent therapeutic modality for CP. Experimental data demonstrated that FMT from CP mouse increased the fibrosis of pancreas through raising the infiltration level of CD4 + T cells and macrophage.…”

Section: Discussionmentioning

confidence: 99%

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Exploring the casual association between gut microbiome, circulating inflammatory cytokines and chronic pancreatitis: A Mendelian randomization analysis

Yang,

Xu,

Liang

et al. 2024

Medicine

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It has been established that gut dysbiosis contributed to the pathogenesis of digestive disorders. We aimed to explore the causal relationships between intestinal microbiota, circulating inflammatory cytokines and chronic pancreatitis (CP). Summary statistics of genome-wide association studies (GWAS) of intestinal microbiome was retrieved from the MiBioGen study and the GWAS data of 91 circulating inflammatory cytokines and CP were obtained from the GWAS catalog. The 2-sample bidirectional Mendelian randomization (MR) analysis was performed between gut microbiota, circulating inflammatory cytokines and CP, in which the inverse variance weighted (IVW) method was regarded as the primary analysis approach. To prove the reliability of the causal estimations, multiple sensitivity analyses were utilized. IVW results revealed that genetically predicted 2 genera, including Sellimonas and Eubacteriumventriosumgroup, and plasm C-C motif chemokine 23 (CCL23) level were positively associated with CP risk, while genus Escherichia Shigella, Eubacteriumruminantiumgroup and Prevotella9, and plasma Caspase 8, Adenosine Deaminase (ADA), and SIR2-like protein 2 (SIRT2) level, demonstrated an ameliorative effect on CP. Leave-one-out analysis confirmed the robustness of the aforementioned causal effects and no significant horizontal pleiotropy or heterogeneity of the instrumental variables was detected. However, no association was found from the identified genera to the CP-related circulating inflammatory cytokines. Besides, the reverse MR analysis demonstrated no causal relationship from CP to the identified genera and circulating inflammatory cytokines. Taken together, our comprehensive analyses offer evidence in favor of the estimated causal connections from the 5 genus-level microbial taxa and 4 circulating inflammatory cytokines to CP risk, which may help to reveal the underlying pathogenesis of CP.

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Section: Discussionmentioning

confidence: 99%

“…[43] SIRT2 were associated with red cell distribution width and red cell distribution width was an important hematological parameter prognostic marker for acute pancreatitis. [44,45]…”

Section: Discussionmentioning

confidence: 99%