Red Cell Distribution Width, Revisited

Constantino, Benie T.

doi:10.1309/lmz1gky9lqtvfbl7

Cited by 44 publications

(38 citation statements)

References 19 publications

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“…RDW changes above normal levels may indicate liver disease, anemia, and nutritional deficiencies. This parameter will increase in all types of anemia, including iron deficiency anemia; when its rates go up it implies anisocytosis (28). RDW rises in the AlCl 3 exposed group increases the risk of anemia caused by Al.…”

Section: Discussionmentioning

confidence: 97%

Comparing the Effects of Saccharomyces boulardii and Selenium-Enriched S. boulardii on Hematological Parameters and Total Antioxidant Capacity in Aluminum Induced Toxicity in Rats

Yaghchi

Fatemi

Ghandehari

2018

J Kermanshah Univ Med Sci

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Background: Oxidative stress induced by aluminum (Al) toxicity leads to the dysfunction of the hematopoietic system. Detoxifying by means of common chelators causes many side effects. Therefore, researchers have been trying to find safer treatments. Objectives: This study aimed to evaluate the effects of Saccharomyces boulardii and S. boulardii enriched with selenium (Se) on Alinduced toxicity in rats. Methods: Female rats were divided into 6 groups: (A) Control group, (B) S. boulardii treatment group, (C) enriched S. boulardii treatment group, (D) Al-infected group, (E) S. boulardii treated and Al-infected group, (F) enriched S. boulardii treated and Al-infected group. At the end of the treatment period, blood samples were taken directly from the hearts of rats in order to measure hematological parameters, total antioxidant capacity (T-AOC), malondialdehyde (MDA) concentrations, iron, and total iron binding capacity (TIBC). Results: Results revealed significant increases of white blood cells (WBC), red cell distribution width (RDW), TIBC and MDA in group D as compared to the control group and significant reductions of these factors in groups E and F as compared to group D. T-AOC, iron, and mean corpuscular volume (MCV) decreased in group D as compared to the control group, but significantly increased in groups E and F as compared to group D. Other observed changes were not statistically significant. Conclusions: It appears that S. boulardii partly reduced the harmful effects of Al toxicity, especially when enriched with Se due to its antioxidant properties. Further studies are needed in this area.

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Section: Discussionmentioning

confidence: 97%

Comparing the Effects of Saccharomyces boulardii and Selenium-Enriched S. boulardii on Hematological Parameters and Total Antioxidant Capacity in Aluminum Induced Toxicity in Rats

Yaghchi

Fatemi

Ghandehari

2018

J Kermanshah Univ Med Sci

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“…It is calculated by all automated haematologic analysers and is quantified as either a co-efficient of variation (CV) or standard of deviation (SD). 1,2 It has traditionally been used along with the mean corpuscular volume to differentiate the types of anaemias. [1][2][3][4] But in recent years, there has been considerable interest in its use as a predictive marker of adverse outcomes in several adult diseases like autoimmune diseases, sepsis, cardiac and pulmonary diseases, operative diseases and critical illnesses.…”

Section: Introductionmentioning

confidence: 99%

High Red Cell Distribution Width as a Biomarker of Mortality in Critically Ill Paediatric Patients

Gauchan¹,

Basnet²

2020

J. Nepal Paedtr. Soc.

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Introduction: Red cell distribution width (RDW) is a frequently overlooked parameter in routine haematological reports. It is a simple and inexpensive test which has been found by many adult studies to be a prognostic indicator of mortality in intensive care units. The objective of this study was to see if high RDW could be used as a marker to predict mortality in critically ill children. Methods: This was a prospective observational study conducted in the paediatric intensive care unit (PICU) of a tertiary hospital of Western Nepal over a period of one year. Study subjects were selected by purposive sampling method. RDW at admission and relative change in RDW (ΔRDW) was compared to see if they had any role in predicting mortality in this group of children. Receiver operating curve analysis was plotted to find an optimal cut-off point to define high and low RDW and various outcome parameters were analysed. Results: Out of 131 children, there were 12 (9.1%) mortalities. Admission RDW was higher in the death group as compared to the survivor group (17 vs 14.6; p = 0.012). Similar finding was seen with ΔRDW (0.45 vs 0.00; p = 0.006). ΔRDW above the cut-off value of 0.15 was found to be associated with a generally more complicated course during hospitalisation as well as had more risk of mortality. Conclusions: Both RDW and ΔRDW above the cut-off value were found to be associated with mortality. In addition, high ΔRDW was also found to predict a more complicated course during hospitalisation.

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“…Red blood cell distribution width (RDW) is a parameter for evaluating the variability of the circulating erythrocyte volume. An elevated RDW implicates dysfunctional erythropoiesis, increased red blood cell destruction, or shortened red blood cell lifespan [4]. RDW shares a close relationship with the prognosis of several diseases.…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Distribution Width Predicts Pulmonary Hypertension Secondary to Chronic Obstructive Pulmonary Disease

Yang

Liu

et al. 2019

Canadian Respiratory Journal

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Purpose. This study aims at investigating the predictive value of red blood cell distribution width (RDW) in pulmonary hypertension (PH) secondary to chronic obstructive pulmonary disease (COPD). Methods. 213 eligible in-hospital COPD patients were reviewed between May 2016 and May 2018, including 39 cases with PH and 174 without PH. Clinical data including demographic characteristics, comorbidities, and results of ultrasound scans, imaging examinations, and laboratory tests were recorded. Results. Increased RDW level was observed in COPD patients with PH compared with COPD patients without PH, with 15.10 ± 1.72% versus 13.70 ± 1.03%, respectively (p<0.001). RDW shared positive relationships with brain natriuretic peptide (BNP) (p=0.001, r = 0.513), pulmonary artery (PA) systolic pressure (p=0.014, r = 0.390), and PA-to-ascending aorta (A) ratio (PA : A) (p=0.001, r = 0.502). Multivariate analysis indicated that RDW, BNP, and PA : A > 1 were the independent risk factors of PH secondary to COPD (p<0.05). The AUC of the RDW in patients with PH was 0.749 ± 0.054 (p<0.001). The optimal cutoff value of RDW for predicting PH was 14.65, with a sensitivity and a specificity value of 69.2% and 82.8%, respectively. Conclusion. RDW is significantly increased in COPD patients with PH and thus may be a useful biomarker for PH secondary to COPD.

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Red Cell Distribution Width, Revisited

Cited by 44 publications

References 19 publications

Comparing the Effects of Saccharomyces boulardii and Selenium-Enriched S. boulardii on Hematological Parameters and Total Antioxidant Capacity in Aluminum Induced Toxicity in Rats

Comparing the Effects of Saccharomyces boulardii and Selenium-Enriched S. boulardii on Hematological Parameters and Total Antioxidant Capacity in Aluminum Induced Toxicity in Rats

High Red Cell Distribution Width as a Biomarker of Mortality in Critically Ill Paediatric Patients

Red Blood Cell Distribution Width Predicts Pulmonary Hypertension Secondary to Chronic Obstructive Pulmonary Disease

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