Red Cell Distribution Width Is Independently Related to Endothelial Dysfunction in Patients With Chronic Kidney Disease

Solak, Yalçın; Yılmaz, Mahmut İlker; Sağlam, Mutlu; Çağlar, Kayser; Verim, Samet; Ünal, Hilmi Umut; Gök, Mahmut; Demirkaya, Erkan; Gaipov, Abduzhappar; Kayrak, Mehmet; Çetinkaya, Hakkı; Eyıleten, Tayfun; Türk, Süleyman; Vural, Abdülgaffar

doi:10.1097/maj.0b013e3182996a96

Cited by 94 publications

(94 citation statements)

References 23 publications

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“…15 Kim et al showed the correlation between increased RDW values and advanced fibrosis in 24,547 patients with nonalcoholic liver disease. 16 The inflammation status of the disease may change the RDW values.…”

Section: Discussionmentioning

confidence: 99%

“…9,11,12 Many studies have shown a correlation between higher RDW values and prognosis, but these studies were about cardiovascular and cerebrovascular diseases, chronic renal failure, liver disease, pancreatitis and venous thromboembolism. [13][14][15][16][17] Kurt et al showed a correlation of nonvalvular atrial fibrillation and higher RDW values in 320 patients. 13 Demir et al conducted a study of 37 patients with cerebral sinus thrombosis and 101 patients with primary headache with a total of 138 patients.…”

Section: Discussionmentioning

confidence: 99%

“…17 RDW is used to show the severity and prognosis of various diseases, and has been found to have the above-mentioned qualities. [13][14][15][16][17] Wang et al showed higher mortality rates with RDW values > 13.4%. 17 In our study, we found sensitivity of 88.2% and specificity of 91.8%, with a cut-off value of 14.35% in ROC analysis.…”

Section: Discussionmentioning

confidence: 99%

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New predictor of acute necrotizing pancreatitis: Red cell distribution width

Yalçın¹,

Taş²,

Kara³

et al. 2018

Adv Clin Exp Med

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Background. Acute pancreatitis (AP) is inflammation of the pancreas of various severity ranging from mild abdominal pain to mortality. AP may be classified as acute interstitial edematous pancreatitis (AEP) or acute necrotizing pancreatitis (ANP), according to the revised Atlanta criteria. Most of the patients with AP are AEP (75-85% of patients), while 15-25% of patients have ANP. The mortality rate is 3% in AEP and 15% in ANP. Thus, it is important to predict the severity of AP to decrease the morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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New predictor of acute necrotizing pancreatitis: Red cell distribution width

Yalçın¹,

Taş²,

Kara³

et al. 2018

Adv Clin Exp Med

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“…To the best of our knowledge, only one study investigated the relationship between RDW and intima media in patients with chronic kidney disease. In the study of Solak et al, it was suggested that RDW has a relationship with IMT and FMD in patients with chronic kidney disease (19).…”

Section: Resultsmentioning

confidence: 99%

The Relationship of Red-Cell Distribution Width and Carotid Intima Media in Chronic Kidney Disease

Güçlü¹,

Tokmak²,

Kaymaz³

et al. 2016

Turk Neph Dial Transpl

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OBJECTIVE: Red-cell distribution width (RDW) is a parameter routinely used for diagnosis of different anemia types. Recent studies have shown the RDW relationship with mortality in general population and patients with cardiovascular disease. However, the number of studies on RDW in chronic kidney disease (CKD) is insufficient. We evaluated the relationship between RDW and carotid intima media thickness (IMT), which is a predictor of atherosclerosis, in patients with CKD. MATERIAL and METHODS:30 healthy controls, 30 patients with CKD, 37 hemodialysis patients were included. IMT was measured with ultrasonography. RESULTS:We identified statistically significant differences in CRP (p: 0.039), hemoglobin (p<0.001), IMK (p<0.001), RDW (p<0.001), urea (p<0.001), creatinine (p<0.001), albumin (p<0.001), uric acid (p<0.001) and ferritin (p<0.001) levels among three groups. In post hoc analysis, the IMK value was statistically significantly higher in the predialysis (p<0.001) and hemodialysis group than healthy controls. IMK value was not statistically different in the hemodialysis group than the predialysis group (p: 0.988). The RDW value was higher in the predialysis group than controls with a trend to statistical significance (p: 0.067). RDW value showed positive correlation with IMK (r: 0.356 P: 0.012) and CRP (r: 0.361 P: 0.004). CONCLUSION:RDW is associated with inflammation and intima media thickness in patients with CKD.KEy wORDS: RDW, Atherosclerosis, Chronic kidney disease Öz AMAÇ: Eritrosit dağılım genişliği (RDW) rutin olarak tam kan sayımından elde edilen bir parametredir. Son yıllarda yapılan çalışmalarda kardiyovasküler hastalığı olanlarda ve sağlıklı gönüllülerde RDW'nin kardiyovasküler hastalıklarla ilişkili olduğu gösterilmiştir. Böbrek yetmezliği hastalarında RDW ile ilgili yeterli çalışma yoktur. Biz kronik böbrek yetmezliği hastalarında RDW'nin aterosklerozun bir ön göstergesi olan karotis intima media kalınlığı (IMK) ile ilişkisini araştırdık. GEREÇ ve yÖNTEMLER: 30 sağlıklı kontrol, 30 kronik böbrek yetmezliği hastası, 37 hemodiyaliz hastası çalışmaya alındı. Hastaların ultrasonografik yöntem ile IMK değerleri ölçüldü.BULGULAR: CRP (p=0,039), hemoglobin (p<0,001), IMK (p<0,001), RDW(p<0,001), üre (p<0,001), kreatinin (p<0,001), albumin (p<0,001), ürik asit (p<0,001) ve ferritin (p<0,001) değerlerinde her üç grup arasında istatistiksel olarak anlamlı farklılık tespit edildi. Posthok analizde IMK değeri prediyaliz grubunda (p<0,001) ve hemodiyaliz grubunda (p<0,001) sağlıklı kontrollere göre istatistiksel olarak anlamlı yüksek tespit edildi. Hemodiyaliz ve prediyaliz gruplarının ortalama IMK değerleri arasında istatistiksel farklılık tespit edilmedi (p:0,988). RDW değeri hemodiyaliz grubunda control grubuna (p:0,046) ve prediyaliz grubuna (p:0,03) göre yüksek saptandı. RDW değeri prediyaliz grubunda control grubuna göre istatistiksel anlalmlılık sınırına yakın yüksek tespit edildi (p: 0,067). RDW değeri IMK (r: 0,356 P: 0,012 ) ve CRP (r: 0,361 P: 0,004 ) ile pozitif korelasyon, gösterdi. SONU...

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“…RDW elevation is seen in patients with CKD [3], Peritoneal Dialysis (PD) or Hemodialysis [4] which is a standard therapy for patients reaching End-Stage Renal Disease (ESRD). RDW has potential use as a biomarker in estimating the risk of mortality.…”

Section: Introductionmentioning

confidence: 99%