Red cell distribution width is associated with albuminuria in adults with familial Mediterranean fever

Abstract

Systematic inflammation, enhanced oxidative stress, and endothelial dysfunction are important for evolution and progression of renal damage, and they cause an increase in red cell distribution width (RDW). Familial Mediterranean fever (FMF) patients who are in the attack-free period and its relation with albuminuria and performance on assessment of microalbuminuria. One hundred and seventy-seven patients who had been diagnosed in accordance with Tel-hoshmer criteria and were in the attack-free period, and 143 age- and sex-matched healthy individuals were enrolled in our study. RDW values of FMF patients were higher compared with those of the controls (13.85 ± 1.07 and 13.15 ± 0.91, respectively; p < 0.0001). RDW values of FMF patients with microalbuminuria were higher compared with those of FMF patients with normoalbuminuria and the control group (p = 0.002 and p < 0.0001, respectively). RDW values of FMF patients with normoalbuminuria were higher compared with those of the control group (p < 0.0001). We have showed RDW levels are positively correlated with albuminuria (r = 0.185, p = 0.014). When assessing microalbuminuria with RDW in the patients, a cutoff value of 13.85 with sensitivity of 60%, specificity of 62%, and p = 0.002 (area under curve: 0.651, 95% confidence interval 0.563-0.738), was observed according to receiver-operating characteristic curve analysis. Among the various variables associated with albuminuria in multivariate logistic regression analyses, RDW remained an independent predictor of albuminuria (95% confidence interval 0.479-0.942, p = 0.021). RDW may be associated with albuminuria in FMF patients and it can be a predictor of microalbuminuria.

The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study

“…RDW is also an inflammatory marker used to predict the potential risk of cardiovascular events and it may be associated with the development of postoperative atrial fibrillation after elective on-pump cardiac surgery as presented [10, 27]. RDW may be associated with albuminuria in familial Mediterranean fever patients and it can be a predictor of microalbuminuria [28]. RDW could be deduced by the percentage ratio of the difference in mean corpuscular volume and mean corpuscular volume.…”

Evaluation of red blood cell distribution width,neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with fibromyalgia

“…In addition to high NLR and PLR values, a high RDW value is also related to chronic subclinical inflammation 7 . In their study, Uslu et al 28 showed higher RDW values in patients with FMF than in healthy subjects. A review of the literature revealed only two clinical studies investigating RDW values in patients with FMS, the first of which found no significant difference in the RDW values of patients with FMS and healthy individuals 15 .…”

Association of body mass index with hemoglobin level, erythrocyte indices and red cell distribution width.

“…18 The RDW acts as a predictor of microalbuminuria. 19 This is due to the fact that RDW is increasing in impaired erythropoiesis (impaired maturation of RBCs).…”