Red cell distribution width in patients with prehypertension and hypertension

Tanındı, Aslı; Topal, Fatih Esad; Topal, Firdevs; Çelik, Bülent

doi:10.3109/08037051.2012.645335

Cited by 100 publications

(97 citation statements)

References 22 publications

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“…Besides, the activity of inflammatory bowel disease (22) as well as pulmonary functions (23) has also been reported to be associated with RDW values (24). RDW has been recently determined to be associated with hypertension and it was an indicator of poor prognosis in heart failure and acute myocardial infarction (10,25,26). Although the mechanism of the relationship between hypertension and RDW was not clearly understood, increased inflammation was the most reasonable theory (27).…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, it has been shown that RDW was higher in prehypertension. Prehypertension was described as slightly elevated blood pressure which would likely turn into high blood pressure (hypertension) in non-pregnant people if lifestyle changes like eating healthier and starting to exercise were not done (10). Furthermore, the association between RDW values and non-cardiac and cardiac mortality in patients with cardiovascular and thrombotic disorders, diabetic ketoacidosis, acute and chronic heart failure, coronary artery disease, and stroke has been investigated (11,12).…”

Section: Introductionmentioning

confidence: 99%

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Erythrocyte Indices in Patients with Preeclampsia

Avcıoğlu¹,

Sezer²,

Altınkaya³

et al. 2015

meandros

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Objective: The purpose of study was to investigate erythrocyte indices in patients with preeclampsia. Materials and Methods:The study population consisted of 102 patients with preeclampsia (49 mild, 53 severe preeclampsia) and 98 control pregnant patients. For the entire study population, red blood cell indices, including baseline mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and red blood cell (RBC) were measured by using an automatic blood counter. Results: In the preeclampsia group, the median RDW was 15% (13.8-16.57), whereas in the control group it was 13.9% (13-15.6) (p<0.01). On the other hand, the mean MCV value was 80.42±7.86 (fL) in preeclampsia group and 83.88±2.31 (fL) in control group (p=0.003). Besides, the mean MCHC value was 33.66±1.71 (g/dL) in preeclampsia group and 33.09±1.48 (g/dL) in control group (p=0.012). However MCH and RBC values were not statistically different between the groups. (p>0.05) Moreover, subgroup analysis revealed that RDW levels were significantly increased in preeclampsia subjects than in mild preeclampsia patients (15.4% (13.9-17.45) vs 14.3% (13.7-15.7), p=0.031), MCV levels were decreased (78.81±7.91 (fL) vs 82.16± 7.43 (fL), p=0.03), RBC values were increased (4.16 (3.79-4.85)x(10 12 /L) vs 3.82 (3.45-4.34)x(10 12 /L), (p=0.006)) in patients with severe preeclampsia when compared to the patients with mild preeclampsia. In the receiver operator characteristic (ROC) analysis of subjects with and without preeclampsia, RDW and MCV showed high predictive values (p<0.01). Besides, in ROC analysis of preeclampsia patients with different severities, RDW and RBC showed the ideal predictive values (p=0.006, p=0.031, respectively). Conclusion: Our study results revealed that among the red blood cell indices, only increased RDW values were associated with both the presence and the severity of preeclampsia.Amaç: Bu çalışmanın amacı preeklampsi tanısı konmuş hastalarda eritrosit indekslerini araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya 102 preeklampsi (49 hafif ve 53 şiddetli preeklampsi olmak üzere) ve 98 kontrol hastası dahil edilmiştir. Tüm çalışma grubunda eritrosit indeksleri olan ortalama korpuskular hacim (MCV), ortalama korpuskular hemoglobin (MCH), ortalama korpuskular hemoglobin konsantrasyonu (MCHC), eritrosit sayımı ve eritrosit dağılım genişliği değerleri otomatik kan sayım cihazı ile ölçüldü.Ad dress for Cor res pon den ce/Ya zış ma Ad re si:

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Erythrocyte Indices in Patients with Preeclampsia

Avcıoğlu¹,

Sezer²,

Altınkaya³

et al. 2015

meandros

View full text Add to dashboard Cite

show abstract

“…Some earlier studies have reported the relationship between RDW and hypertension. Tanindi et al demonstrated that RDW is higher in prehypertensive and hypertensive patients than in healthy controls, and that RDW values have a strong relationship with SBP and DBP (20) . However, that study did not include an isolated systolic hypertension group.…”

Section: Discussionmentioning

confidence: 99%

Elevated Red Blood Cell Distribution Width is Associated with Isolated Systolic Hypertension

Yıldırım¹

2017

Kosuyolu Heart Journal

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Introduction: The aim of this study was to determine the relationship between isolated systolic hypertension and red blood cell distribution width (RDW).Patients and Methods: Eighty-one patients were included in the study. Blood pressure was measured by a cardiologist using a manual sphygmomanometer, and the patients were divided into 2 groups as isolated systolic hypertensive and normotensive based on the European Society of Hypertension classification. Complete blood counts (CBC) and biochemical values of each patient were measured using standard methods.Results: There was significant difference between the mean RDW values of the isolated systolic hypertensive and the normotensive groups. While there was a strong association between high RDW values and isolated systolic hypertension, there were no significant differences between the 2 groups for any of the other measured laboratory values. Conclusion:High RDW value appears to be a strong and independent predictor of isolated systolic hypertension.Key Words: Red cell distribution width; hypertension; erythrocyte indices Yükselmiş Kırmızı Kan Hücresi Dağıtım Genişliği İzole Sistolik Hipertansiyon ile İlişkilidir ÖZETGiriş: Bu çalışmanın amacı, izole sistolik hipertansiyon ve kırmızı kan hücresi dağılım genişliği (RDW) arasındaki ilişkiyi belirlemektir. Hastalar ve Yöntem:Toplam 81 hasta çalışmaya dahil edildi. Kan basıncı manuel sfingomanometre kullanarak bir kardiyolog tarafından ölçüldü ve hastalar Avrupa Hipertansiyon Topluluğu sınıflandırmasına dayalı olarak normotansif ve izole sistolik hipertansif olarak iki gruba ayrıldı. Tam kan sayımı ve her hastanın biyokimyasal değerleri standart yöntemler kullanılarak ölçüldü. Bulgular: İzole sistolik hipertansif ve normotansif grupların ortalama RDW değerleri arasında anlamlı bir fark tespit edildi. Yüksek RDW değerleri ve izole sistolik hipertansiyon arasında güçlü bir ilişki varken, diğer ölçülen laboratuvar değerleri bakımından iki grup arasında anlamlı farklılık yoktu.Sonuç: Yüksek RDW değeri izole sistolik hipertansiyon için güçlü ve bağımsız bir belirleyici olarak tespit edildi.Anahtar Kelimeler: Kırmızı kan hücresi dağılım genişliği; hipertansiyon; eritrosit indeksleri

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“…However, recent studies have found that it is correlated strongly with heightened systolic and diastolic blood pressure and is a poor prognostic indicator in cardiovascular disorders. [4,5,11] Ozcan et al have attributed the rise of RDW in hypertensive disorders to the increased inflammatory response. [12] By impairment of iron metabolism and disturbance in erythropoiesis, it could also result in the release of excess of reticulocytes and disruption in erythrocyte maturation.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent evidence has shown that increased levels are also seen in hypertension and other cardiovascular disorders. [4,5] It is also associated with diabetic ketoacidosis, thrombotic disorders, malignancies and hepatorenal diseases. [6,7,8] However, there is limited data on the usefulness of RDW in pregnant population and especially the hypertensive disorders of pregnancy.…”

Section: Introductionmentioning

confidence: 99%